Clinical trials: Mask
Dry Eye Syndromes
A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease
The purpose of the study is to evaluate dose-response, efficacy and safety of CP-690,550 eye drops in patients with dry eye disease.
- Trial name
- NCT01135511
- Testing
- CP-690,550 Eye drops, CP-690,550 Eye drops-vehicle, Sodium Hyaluronate
- Where
- 28 sites in Japan, South Korea
- Volunteers
- 285 people
- Sponsor
- Pfizer
Diabetic Macular Edema
Oxulumis® Suprachoroidal Microcatherization of Triesence® in Diabetic Macular Edema
The purpose of this clinical trial is to evaluate the safety and tolerability of suprachoroidal microcatheterization with the Oxulumis® device for a randomized treatment with two dose levels of Triesence® in subjects with…
- Trial name
- CAPE (NCT05512962)
- Testing
- Triamcinolone Acetonide, Semi-automated Suprachoroidal Microcatheter
- Where
- 6 sites in United States
- Volunteers
- 25 people
- Sponsor
- Oxular Limited
Allergic Conjunctivitis
Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic Conjunctivitis
Allergic conjunctivitis (AC) afflicts approximately 20% of the US population. Typically, patients manifest symptoms in the spring, summer and fall, when airborne allergens are at their peak.
- Trial name
- NCT01443442
- Testing
- bepotastine besilate, 1.5%, Loteprednol etabonate
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Cataract
Accommodation Measurements After Bilateral Implantation of an Aspheric Accommodating Lens and Monofocal Aspheric Lenses
The objective of this study is to demonstrate the correlation of near vision and changes in higher order aberrations following lens extraction and to characterize the defocus curves of Crystalens® AO™ intraocular lens (IOL)…
- Trial name
- NCT01241279
- Testing
- Crystalens AO, SoftPort LI61AO
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bausch & Lomb Incorporated
Vitreomacular Adhesion Including Macular Hole
Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole
The purpose of this study is to evaluate the treatment of symptomatic vitreomacular adhesion / (VMT) including macular hole with ocriplasmin.
- Trial name
- OASIS (NCT01429441)
- Testing
- Ocriplasmin
- Where
- 25 sites in United States
- Volunteers
- 220 people
- Sponsor
- ThromboGenics
Open-angle Glaucoma, Ocular Hypertension
Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension
To evaluate ocular hypotensive efficacy and safety of PG324 Ophthalmic Solution compared to netarsudil (AR-13324) ophthalmic solution 0.02% and latanoprost ophthalmic solution 0.005%
- Trial name
- NCT02674854
- Testing
- PG324 Ophthalmic Solution 0.02%/0.005%, Netarsudil (AR-13324) ophthalmic solution 0.02%, Latanoprost ophthalmic solution 0.005%
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Aerie Pharmaceuticals
Gastroparesis
Buspirone for Early Satiety and Symptoms of Gastroparesis
This study evaluates whether the study medication, buspirone, an antianxiety drug, improves the symptoms of gastroparesis in patients with gastroparesis symptoms and at least moderately severe symptoms of fullness and/or…
- Trial name
- BESST (NCT03587142)
- Testing
- Buspirone
- Where
- 6 sites in United States
- Volunteers
- 96 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Primary Open Angle Glaucoma, Ocular Hypertension
Dose-Finding Study Comparing the Safety and Efficacy of Latanoprost to a Novel Treatment for Glaucoma
This study will evaluate the safety and efficacy of PF 03187207.
- Conditions
- Primary Open Angle Glaucoma, Ocular Hypertension, Pigmentary Glaucoma, Pseudoexfoliative Glaucoma
- Trial name
- NCT00441883
- Testing
- PF-03187207 and Latanoprost Vehicle, Latanoprost 0.005% and PF-03187207 Vehicle
- Where
- 19 sites in United States
- Volunteers
- 176 people
- Sponsor
- Bausch & Lomb Incorporated
Active, Symptomatic Blepharitis
Comparative Study to Evaluate ISV-305 Compared to Vehicle in Blepharitis Subjects
The purpose of this study is to evaluate the clinical efficacy and safety of ISV-305 (Dexamethasone in DuraSite® 2) compared to Vehicle in the treatment of subjects with active, symptomatic Blepharitis.
- Trial name
- ISV-305 (NCT01543490)
- Testing
- ISV-305, Vehicle
- Where
- United States
- Volunteers
- 558 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Respiratory Distress Syndrome
The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age
The primary objective of this study is to evaluate the safety and efficacy of lucinactant for inhalation administered as an aerosolized dose in two doses to preterm neonates 26 - 32 weeks gestational age who are receiving nasal…
- Trial name
- NCT02636868
- Testing
- Lucinactant delivered via investigational delivery device, nCPAP
- Where
- 54 sites in United States, Canada and 6 more
- Volunteers
- 221 people
- Sponsor
- Windtree Therapeutics
Allergic Conjunctivitis
A Single-Center,Evaluation of the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle
The purpose of this study is to evaluate the onset and duration of action of AC-170 0.24% compared to vehicle in the prevention of the signs and symptoms of allergic conjunctivitis in the conjunctival allergen challenge (CAC)…
- Trial name
- NCT01685242
- Testing
- AC-170 0.24%, AC-170 0%
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Aciex Therapeutics, Inc.
Edentulism
Success Rate of Immediately Loaded Implants With Platform Switched Design Placed in Anterior Part of Mandible and Restored With Fixed Prostheses
Change in crestal bone level implants at 5% significance level.
- Trial name
- NCT00780273
- Testing
- Ankylos Implants, Biomet 3i Prevail Implants
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Dentsply International
Raised Intraocular Pressure
A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure
The purpose of this study is to evaluate the efficacy of systemically administered AZD4017, compared with placebo, over a 28-day period in patients with raised intra-ocular pressure (IOP).
- Trial name
- NCT01173471
- Testing
- AZD4017
- Where
- 11 sites in United States, Sweden and 1 more
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
Presbyopia
Phase 1/2 Study of AGN-241622 in Healthy Participants and Participants With Presbyopia
The objective of this study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of AGN-241622 ophthalmic solution for the first time in human participants
- Trial name
- NCT04403763
- Testing
- AGN-241622, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- AbbVie
Geographic Atrophy
A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
This is a dose finding study designed to evaluate the efficacy, safety, and pharmacokinetics of danicopan in participants with GA secondary to AMD.
- Trial name
- NCT05019521
- Testing
- Danicopan
- Where
- 128 sites in United States, Australia and 11 more
- Volunteers
- 365 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Diabetic Macular Edema (DME)
Study to Compare Efficacy and Safety of CT-P42 in Comparison With Eylea in Patients With Diabetic Macular Edema
This is a Randomized, Active-Controlled, Double-Masked, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P42 in comparison with Eylea in Patients with Diabetic Macular Edema
- Trial name
- NCT04739306
- Testing
- CT-P42, Eylea
- Where
- Slovakia
- Volunteers
- 348 people
- Sponsor
- Celltrion
Obstructive Sleep Apnea
Evaluation of a Full-Face Mask for the Treatment of Obstructive Sleep Apnea (OSA)
The investigation is designed to evaluate the comfort, ease of use and performance of a trial nasal mask for the treatment of Obstructive Sleep Apnea (OSA) in the home environment.
- Trial name
- NCT03329352
- Testing
- F&P Full-Face Mask
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Fisher and Paykel Healthcare
Myopia, Pathological
VEGF Trap-Eye in Choroidal Neovascularization Secondary to Pathologic Myopia (mCNV)
VEGF Trap-Eye will be tested for safety and efficacy in patients with vision loss due to choroidal neovascularization secondary to pathologic myopia. This will be a placebo-controlled trial.
- Trial name
- Myrror (NCT01249664)
- Testing
- VEGF Trap-Eye (BAY86-5321), No Drug
- Where
- 20 sites in Hong Kong, Japan and 3 more
- Volunteers
- 122 people
- Sponsor
- Bayer
Cataract
Phaco Versus Small Incision Cataract Surgery (SICS) Health Economic Study
To compare the health economic parameter and clinical outcome of Phacoemulsification with small incision cataract surgery (SICS)
- Trial name
- NCT00762606
- Testing
- Phacoemulsification cataract extraction surgery, Small incision cataract surgery
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Alcon Research
Diabetic Macular Edema
Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with visual impairment due to diabetic macular edema (DME).
- Trial name
- KESTREL (NCT03481634)
- Testing
- Brolucizumab, Aflibercept
- Where
- 116 sites in United States, Argentina and 12 more
- Volunteers
- 566 people
- Sponsor
- Novartis Pharmaceuticals