Clinical trials: Mass Balance Study
Healthy Subjects
A Study to Evaluate Cenerimod in Healthy Male Subjects
The main objective of the study is to investigate the rate and routes of elimination of cenerimod and the mass balance in urine, feces, and expired air
- Trial name
- NCT02914223
- Testing
- Cenerimod
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Healthy Subjects
A Study of [14C]IBI351 in Healthy Subjects
This study is to evaluate the mass balance of single oral dose of [14C] IBI351 in healthy subjects. Six to eight healthy male subjects were planned to be enrolled.
- Trial name
- NCT05626179
- Testing
- [14C] IBI351
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Single Dose Of GSK189075 Taken By Mouth Containing Small Amounts Of Radioactivity Studied In Healthy Male Volunteers
This study will look at the relative amounts of GSK189075 that are found in samples of blood, urine, and feces of healthy male volunteers.
- Trial name
- NCT00501683
- Testing
- Radiolabelled GSK189075
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Female Participants
A Study to Evaluate the Metabolism, the Routes and Extent of Elimination, and Drug Levels of [14C]Navlimetostat (BMS-986504) in Healthy Female Participants
The purpose of this study is to evaluate the metabolism, the routes and extent of elimination, and drug levels of [14C]Navlimetostat (BMS-986504) in healthy female participants
- Trial name
- NCT07777133
- Testing
- Navlimetostat, [14C]Navlimetostat
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Healthy Participants
A Study to Assess the Mass Balance, Pharmacokinetics, and Metabolite Profiles of a Single Oral Dose of [14C]-INCB161734 in Healthy Male Participants
This study is conducted to assess the mass balance, pharmacokinetics, and metabolite profiles of a single oral dose of [14C]-INCB161734 in healthy male participants.
- Trial name
- NCT07814404
- Testing
- INCB161734
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
Healthy
Evaluation of Mass Balance and Absolute Bioavailability of GLPG1205
A study in healthy male volunteers to assess how the radiolabelled test medicine is taken up and broken down by the body when given by short infusion into a vein and when given by the mouth in the form of a capsule or tablet.
- Trial name
- NCT04704739
- Testing
- GLPG1205 film-coated tablets, [14C]-GLPG1205 solution for infusion, GLPG1205 capsules
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Complement Mediated Primary or Secondary Glomerular Diseases
A Study to Evaluate the Mass Balance of [14C] HRS-5965 in Healthy Adult Male Volunteers
Evaluate the Mass Balance of [14C] HRS-5965 in Healthy Adult Volunteers.
- Trial name
- NCT06567392
- Testing
- [14C] HRS-5965
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Secondary Hypogonadism
An Open-Label, Single-Dose Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of Radiolabeled Androxal in Healthy Male Subjects After Oral Administration
The purpose of this study is to investigate the route(s) of elimination and mass balance of enclomiphene after oral administration of a single 25 mg (approximately equivalent to [(~]) 500 nanocurie [nCi]) dose of [14C]Androxal in…
- Trial name
- NCT02274181
- Testing
- Androxal
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Pruritus
A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1405
The primary objectives of the study are: To assess the mass balance recovery after a single PO dose of [14C]-SK-1405 To provide plasma, urine and faecal samples for metabolite profiling and structural identification
- Trial name
- NCT02846181
- Testing
- [14C]-SK-1405
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Healthy
A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects
A study to examine the safety, tolerability, and pharmacokinetics of single- and multiple-ascending doses of ACT-1014-6470 in healthy subjects
- Trial name
- NCT04183686
- Testing
- ACT-1014-6470 (SAD), ACT-1014-6470 (MAD), 14C-ACT-1014-6470 microtracer
- Where
- Netherlands
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Healthy Volunteer
Mass Balance Study With MT-7117
This is a single-centre, open-label, mass balance study in healthy male subjects utilising a single oral dose of [14C] MT 7117.
- Trial name
- MT-7117 MB (NCT03503266)
- Testing
- [14C] MT-7117
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tanabe Pharma America, Inc.
Healthy
Pharmacokinetics and Excretion of Oral [14C]-Rodatristat Ethyl
This is an open-label study to evaluate the PK and excretion of a single oral dose of [14C]-rodatristat ethyl. The study will consist of: Screening evaluations (within 29 days prior to dosing); a treatment phase (from dosing…
- Trial name
- NCT05006118
- Testing
- Radio-labeled rodatristat ethyl 600 mg
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Altavant Sciences GmbH
Cardiovascular Disease
Study Evaluating the Pharmacokinetic and Mass Balance of Single Dose [14C] AZD5718 in Volunteers
The Sponsor is developing the test medicine, AZD5718, for the potential treatment of cardiovascular disease. The study is an open-label, single dose study involving 6 healthy male subjects.
- Trial name
- NCT03948451
- Testing
- [14C]AZD5718 Oral Suspension
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Male Volunteers
Study to Investigate the Mass Balance and Biotransformation of SIM0417 in Healthy Adult Chinese Male Participants
This is a non-randomized, open-label, single-dose, Phase I clinical study to evaluate the mass balance and biotransformation, safety and tolerability of SIM0417 in healthy Chinese adult male subjects following a single oral…
- Trial name
- NCT05475834
- Testing
- SIM0417
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
OIC
TD-1211 IV/Oral Mass Balance Study
The purpose of this study is to determine TD-1211 is processed by the body.
- Trial name
- NCT01702194
- Testing
- TD-1211 IV [C14], TD-1211 PO [C14]
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glycyx Therapeutics
Healthy Participants
Mass Balance Clinical Trial of SIM0270
This is a single-center, non-randomized, open-label, single-cohort, single-dose phase I clinical study in healthy Chinese adult male subjects.
- Trial name
- NCT06654791
- Testing
- [14C] SIM0270 Oral Preparation
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Type 2 Diabetes Mellitus, Weight Loss
Mass Balance Study of [14C]HRS9531 in Healthy Male Subjects
This study was a single-center, single-dose, open-label study in healthy male subjects to investigate the absorption, metabolism and excretion of HRS9531 after a single subcutaneous injection of [14C]HRS9531.
- Trial name
- NCT06855147
- Testing
- [14C]HRS9531
- Where
- China
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Healthy
Mass Balance Recovery and Metabolite Profile of CORT125281 in Healthy Male Participants
This study will evaluate the mass balance recovery and metabolite profile, and will identify metabolite structures following a single oral dose of 14C-CORT125281 in healthy participants.
- Trial name
- NCT03877952
- Testing
- 14C-CORT125281
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Healthy Male Subjects
Study of RPT193 in Healthy Adult Male Subjects
Phase 1, open-label, absorption, metabolism, excretion, and mass balance study.
- Trial name
- NCT06087978
- Testing
- 14C RPT193
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- RAPT Therapeutics, Inc., a member of the GSK plc group of companies
Healthy Adult Subjects
Mass Balance Study of [14C]DA-302168S in Healthy Chinese Adult Male Participants
In this study, a single dose of [14C] radiolabelled DA-302168S will be administered orally. The main purpose of this study is to find out how much of DA-302168S and its metabolites pass from blood into urine and feces, and…
- Trial name
- NCT07857265
- Testing
- [14C] DA-302168S
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Chendu DIAO Pharmaceutical Group CO., LTD.