Clinical trials: Mass Balance Study
Advanced Solid Tumors, Pharmacokinetics of 14C-OSI-906
A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the Body
The purpose of this study is to evaluate the pharmacokinetics, in particular the routes of excretion and extent of metabolism of OSI-906 after a single oral dose of 14C-labeled OSI-906.
- Trial name
- NCT01529684
- Testing
- radio-labeled OSI-906, OSI-906
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Healthy
Evaluation of Mass Balance and Absolute Bioavailability of GLPG3667
This is a study in healthy male volunteers to assess how a new test medicine is taken up and broken down by the body as well as its safety and tolerability.
- Trial name
- NCT05335447
- Testing
- GLPG3667 capsule, [14C]-GLPG3667 solution for infusion, [14C]-GLPG3667 capsule
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Lakefront Biotherapeutics NV
Parkinson Disease
Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-BIA 9-1067
The purpose is to and to assess the mass balance recovery after a single oral dose of [14C]-BIA 9-1067 and to provide plasma, urine and faecal samples for metabolite profiling and structural identification.
- Trial name
- NCT03119194
- Testing
- [14C]-BIA 9-1067
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Acromegaly
Single-dose Study to Evaluate the Absolute Bioavailability and Mass Balance of ONO-5788
A phase 1 healthy volunteer study to assess the excretion and metabolism as well as the absolute bioavailability of oral ONO-5788.
- Trial name
- ONO-5788-02 (NCT03849872)
- Testing
- ONO-5788, [14C]-ONO-5788
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Healthy Adult Male Volunteers
ADME Study of [14C]-Jaktinib in Healthy Male Subjects
This study was designed to evaluate the mass balance and biotransformation after single-dose of [14C]-Jaktinib orally in Chinese healthy male subjects.
- Trial name
- NCT05150717
- Testing
- [14C]-Jaktinib
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
ADME
Mass Balance Study of [14C]Xeruborbactam (QPX7728) in Healthy Adult Male Participants
This is a single-dose, phase 1 open-label study to determine the mass balance recovery and metabolic profiling and identification for intravenous (IV) administered [14C]xeruborbactam.
- Trial name
- NCT07083817
- Testing
- [14C]Xeruborbactam
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Qpex Biopharma, Inc.
Healthy Volunteers
Single-dose Mass Balance Recovery and Metabolite Profile and Identification of 14C-XEN1101
This study will evaluate the mass balance recovery and metabolite profile, and will identify metabolite structures following a single oral dose of 14C-XEN1101 in healthy adult male subjects.
- Trial name
- NCT04952467
- Testing
- 14C-XEN1101
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Healthy Male Subjects
A Mass Balance Study of TS-172 in Healthy Adult Subjects
To assess the plasma pharmacokinetics, the routes extent of elimination, and the metabolites of TS-172 after single oral dose of [14C] TS-172 in Japanese healthy male subjects.
- Trial name
- NCT06596356
- Testing
- [14C] TS-172
- Where
- Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Healthy
Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]NXL104
A study to look at how radiolabelled NXL104 is taken up, broken down and removed by the body when given as an injection into the blood stream.
- Trial name
- NCT01448395
- Testing
- [14C]NXL104
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
A Metabolite Identification, Mass Balance, and PK Study of [14C]-Asimadoline to Healthy Adult Male Volunteers
This is an open label, single center, metabolite identification, mass balance, and PK study in healthy male volunteers.
- Trial name
- NCT01380561
- Testing
- asimadoline
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tioga Pharmaceuticals
Healthy Subjects
A Mass Balance Study of [14C]ABSK021
This study is a single-site, open-label, single-cohort, single-dose study to assess the absorption, metabolism, and excretion profile of [14C] ABSK021 in healthy adult male subjects.
- Trial name
- NCT06186583
- Testing
- Pimicotinib（ABSK021）
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Hemodialysis Subjects With Secondary Hyperparathyroidism
A Mass Balance Study of [14C] MT1013 in Hemodialysis Subjects With Secondary Hyperparathyroidism
MT1013 is a first-in-class dual-target agonist.This study is being conducted to determine the mass balance and routes of excretion of total radioactivity after the dose of [14C] MT1013.
- Trial name
- NCT07284043
- Testing
- [14C] MT1013/MT1013 Injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shaanxi Micot Pharmaceutical Technology Co., Ltd.
Healthy Subjects, Pharmacokinetics of MDV3100
A Study to Explore the Routes of Elimination of MDV3100
A study to investigate the excretion routes of radio-labelled MDV3100.
- Trial name
- NCT01911715
- Testing
- MDV3100
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Imumune Thrombocytopenia(ITP) Human Mass Balance
Human Mass Balance of [14C]HMPL-523 in Healthy Adult Male Chinese Subjects
To evaluate the absorption, metabolism and excretion of HMPL-523 in healthy male Chinese subjects following multiple oral doses of HMPL-523 tablets followed by a single oral dose of [14C]HMPL-523 suspension
- Trial name
- NCT05781906
- Testing
- HMPL-523, 150 µCi [14C]HMPL-523
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hutchmed
Healthy Adult Male Subjects
A Human Mass Balance Study to Determine the Total Recovery of Radioactivity in Urine and Faeces Following a Single Oral Dose of 14C Radiolabelled ONO-4053
This is a single dose mass balance study in healthy adult male volunteers to investigate the metabolism and excretion of [14C]-ONO-4053.
- Trial name
- NCT01909986
- Testing
- [14C]ONO-4053
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Parkinson Disease
Mass Balance Recovery and Metabolite Identification of Carbon-14 BIA 28-6156
The study is designed to determine the absorption, distribution, metabolism and elimination (ADME) of BIA 28-6156 in humans, further explore the PK of BIA 28-6156, evaluate the extent of distribution of total radioactivity into…
- Trial name
- NCT05220072
- Testing
- Carbon-14 BIA 28-6156
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Bial R&D Investments, S.A.
Healthy
Single Dose Study To Study The Absorption, Metabolism And Excretion Of PF-04991532
The purpose of this study is to evaluate the excretion balance, metabolic profile and the routes of excretion of [14C]PF-04991532 in healthy adult male subjects.
- Trial name
- NCT01469481
- Testing
- PF-04991532
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers
Disposition of 14C-LY2452473 Following Oral Administration in Healthy Human Subjects
This is a single dose study of radiolabeled [14C]-LY2452473 in healthy male volunteers to study the absorption, distribution, metabolism, and elimination of LY2452473.
- Trial name
- NCT01275157
- Testing
- LY2452473
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy Male Subjects
Single Dose Study With Unlabeled Dose and 14C-labeled Microdose of PF-06700841 in Healthy Male Subjects
An open-label, fixed sequence, 2-period including a single oral dose 60 mg PF-06700841 with 14C-labeled microtracer in 1st period, and a single oral dose of 60 mg unlabeled PF-06700841 followed by intravenous administration of…
- Trial name
- NCT03770039
- Testing
- Oral PF-06700841 containing 14C microtracer, Oral unlabeled PF-06700841, IV 14C-labeled PF-06700841
- Where
- 2 sites in Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pfizer
Peripheral Analgesic and Anti-itch
Pharmacokinetics, Mass Balance, and Metabolism of [14C]HSK21542 in Healthy Adult Male Volunteers.
This is a single-center, nonrandomized, and open design study to investigate the pharmacokinetics, mass balance, metabolism and excretion of HSK21542 in healthy male subjects.
- Trial name
- NCT05835934
- Testing
- [14C]HSK21542
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.