Clinical trials: Masses
Fine Needle Aspiration, Pancreatic Mass
EUS FNB Versus FNA With On-Site Cytopathology in Solid Pancreatic Masses
The objective of this paired cohort study is to evaluate the diagnostic accuracy of Endoscopic Ultrasound-fine needle aspiration (EUS-FNA) with rapid onsite evaluation (ROSE) compared to EUS-fine needle biopsy (EUS-FNB) without…
- Trial name
- NCT03485924
- Testing
- EUS-FNA with ROSE, EUS-FNB without ROSE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Pancreatic Cyst, Pancreatic Neoplasms
Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract
This study focuses on four different lesions: pancreatic cysts, lymph nodes near the gastrointestinal tract, pancreatic masses and GIST tumors.
- Conditions
- Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer
- Trial name
- US-nCLE (NCT01770405)
- Testing
- Endoscopic ultrasound fine needle aspiration
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Mammography, Breast Cancer
Searching for Masses and Calcifications at the Same Time in Breast Cancer Screening
Brief Summary A task like breast cancer screening (mammography) can be described as a "hybrid search" task. In basic visual search tasks, observers search for a target among distractors that are not the target.
- Conditions
- Mammography, Breast Cancer, Radiology
- Trial name
- NCT05975736
- Testing
- Search only for masses, Search only for calcifications, Search for both together
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pancreatic Neoplasm
Comparison of Two Fine Needle Biopsy Needles for Solid Pancreatic Masses
This is a randomized prospective clinical study comparing the Acquire Biopsy Device to SharkCore Biopsy Device.
- Trial name
- Expect (NCT02910960)
- Testing
- Acquire EUS Biopsy Device, SharkCore Biopsy System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- AdventHealth
Adrenal Mass
Gallium-68 Labeled Pentixafor PET/CT in Adrenal Masses
The CXC chemokine receptor type 4 (CXCR4), which is a G protein-coupled receptor expressed on the surface of the cell membrane, contributes to the development and progression of malignancies and functional endocrine disorders.
- Trial name
- NCT04859959
- Testing
- Gallium-68 Pentixafor PET/CT
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Renal Cancers
Cryoablation Versus Radiofrequency Ablation for Small Renal Masses
The purpose of this study is to verify the oncological efficacy and safety of cryoablation and radiofrequency ablation for the treatment of small renal tumors.
- Trial name
- NCT00922948
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Canada
- Sponsor
- St. Joseph's Healthcare Hamilton
Renal Cell Carcinoma (RCC)
ClAmpless, Sutureless PartIAl Nephrectomy for Renal Masses
During partial nephrectomy surgery, efforts at minimizing ischemia while maximizing renal parenchymal volume are desirable to preserve renal function1,2.
- Trial name
- CASPIAN (NCT06722807)
- Testing
- sutureless, clampless partial nephrectomy
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Florida
Clear Cell Renal Cell Carcinoma
89Zr-TLX250 for PET/CT Imaging of ccRCC- ZIRCON Study
89Zr-TLX250 is under clinical development as a diagnostic agent targeting clear cell renal cell carcinoma.
- Trial name
- 89ZR-TLX250 (NCT03849118)
- Testing
- 89Zr-girentuximab
- Where
- 31 sites in United States, Australia and 6 more
- Volunteers
- 300 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Limited
Ovary Cancer
The Efficacy and Safety of FRD001 in Ultrasound Contrast Imaging for Malignant Ovarian Masses in Women
This is a Prospective, Self-Controlled, Open-Label, Multicenter Clinical Trial. The purpose of this study is to demonstrate the efficacy and safety of FRD001 injection in ultrasound contrast imaging for the differentiation…
- Trial name
- NCT06556342
- Testing
- FRD001
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Tongji Hospital
Ovarian Cysts, Ovarian Cancer
Radiomics and Machine Learning in the Diagnosis of Ovarian Masses
The correct differential diagnosis between benign and malignant adnexal masses is the main goal of preoperative ultrasound diagnostics and is very important to plan the correct treatment for the patient in terms of surgical team…
- Trial name
- Multi-AROMA (NCT06342934)
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Breast Cancer
Investigation of Ultrasound Imaging and Spectroscopy for Characterizing Breast Masses
Our objective in this study is to identify an optimal set of quantitative ultrasound parameters that can be used, non-invasively, to characterize breast masses with high accuracy, as determined histopathologically.
- Trial name
- NCT04050423
- Where
- Canada
- Volunteers
- 1,200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sonography, Ovarian Mass
Sonographic Evaluation of Ovarian Masses by ORADS System
This observational study will evaluate how well an ultrasound scoring system called O-RADS can distinguish between benign (non-cancerous) and malignant (cancerous) ovarian masses in women aged 18 to 70 years.
- Trial name
- NCT07289126
- Volunteers
- 80 people
- Sponsor
- Assiut University
Patients With Brain Masses/Lesions
Register for Longitudinal Recording of Brain Function
The aim of this observational register study is to establish a registry that completely records and compiles the data from routinely performed technical examinations (navigated transcranial magnetic stimulation, intraoperative…
- Trial name
- NCT06401057
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital Heidelberg
Patients With Newly Diagnosed Small Renal Masses(<4cm)
The Natural History of Small Renal Masses
There is a rising incidence of incidentally detected small renal tumours due to improved imaging techniques. Traditionally, patients diagnosed with these small renal masses undergo surgery and therefore there is limited data…
- Trial name
- NCT01305330
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University Health Network, Toronto
Breast Cancer
Photoacoustic Imaging for Characterizing Breast Masses and Breast Tumor Response to Neoadjuvant Chemotherapy
Our objective in this pilot study will be to identify PA parameters that can distinguish benign vs. malignant lesions, and also, if PA parameters change with within breast tumors during chemotherapy treatment over time.
- Trial name
- NCT04428528
- Testing
- Photoacoustics Imaging System
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node
Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes
The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well…
- Conditions
- Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node, Benign Neoplasm of Lymph Nodes, Benign Pancreatic Tumors
- Trial name
- ADVEUS (NCT02459041)
- Testing
- Elastography, contrast enhancement
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Solid Pancreatic Masses
Endoscopic Ultrasound-guided Fine Needle Biopsy With 25-gauge Biopsy Needles for Solid Pancreatic Masses
For 12 months after approvement by the University of Yonsei institutional review board, of the 59 patients older than 20 years referred to our medical center for EUS-FNA or FNB, all consecutive pancreatic lesions were evaluated…
- Trial name
- NCT01795066
- Testing
- EUS-FNB with 25-gauge (Echotip ProCore; Cook Endoscopy Inc, Limerick, Ireland)
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Pancreas Mass Diagnosis
Comparing Methods to Biopsy Pancreas Mass
This study will examine whether there is any difference in number of passes needed to diagnose pancreatic masses during endoscopic ultrasound-guided biopsies using 2 different types of needles.
- Trial name
- NCT01663493
- Testing
- FNB
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Brigham and Women's Hospital
Pancreatic Adenocarcinoma, Pancreas Cancer
Repeated EUS-guided Fine Needle Biopsy of Pancreatic Masses After Non-diagnostic or Inconclusive Results
The primary aim of REuBio study is to evaluate the diagnostic accuracy of repeated endoscopic ultrasound-guided fine needle biopsy after a previous non-diagnostic or inconclusive EUS-guided sampling of solid pancreatic lesions.
- Conditions
- Pancreatic Adenocarcinoma, Pancreas Cancer, Pancreas Metastases
- Trial name
- REuBio (NCT05226572)
- Testing
- endoscopic ultrasound-guided fine needle biopsy
- Where
- Italy
- Volunteers
- 462 people
- Sponsor
- University of Bologna
Renal Masses
Comparison of OpeN VErsus RoboTic Partial Nephrectomy
A prospective randomized controlled feasibility trial for patients undergoing partial nephrectomy for T1 renal masses at Princess Margaret. Participants will be randomized receive either open or robotic partial nephrectomy.
- Trial name
- CONVERT (NCT04011891)
- Testing
- Robotic Partial Nephrectomy, Open Partial Nephrectomy
- Where
- Canada
- Sponsor
- University Health Network, Toronto