Clinical trials: Maternal Obesity Complicating Pregnancy
Pregnant Women, Gestational Diabetes
Physical Acvitiy in Pregnancy
The goal of this observational study is to learn how a physically active lifestyle during pregnancy affects placental development and function.
- Conditions
- Pregnant Women, Gestational Diabetes, Obese But Otherwise Healthy Participants, Overweight (BMI > 25)
- Trial name
- NCT07356180
- Testing
- Pregnancy Physical Activity Questionnaire (PPAQ)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Maternal Obesity, Gestational Weight Gain
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Obesity is a serious and increasing health problem in the Western World with about one third of all pregnant women in Denmark being overweight. Among these are more than 11% severe obese.
- Conditions
- Maternal Obesity, Gestational Weight Gain, Obstetric Complications
- Trial name
- LiP (NCT00530439)
- Testing
- Lifestyle intervention, Control, Physical activity, dietetic counselling
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Gestational Diabetes, Overweight and Obesity
Educational Intervention in the First 18 Months of Life to Prevent/Manage Obesity of Children After Gestational Diabetes
In order to evaluate the effect of an educational intervention on mothers with gestational diabetes and their offspring in the first 18 months of life, The intervention will be applied to mothers with gestational diabetes, and a…
- Trial name
- NCT04493177
- Testing
- Educational intervention, Conventional treatment Guia de Practica Clinica IMSS-029-08
- Where
- Mexico
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Pregnancy Complications, Obesity
Acute Exercise Effects in Obese Pregnancy
Obesity before and during pregnancy is associated with a higher risk for a number of obstetric and metabolic complications in women and their offspring.
- Conditions
- Pregnancy Complications, Obesity, Pre-Eclampsia, Gestational Diabetes
- Trial name
- NCT03750695
- Testing
- Resistance exercise, Aerobic Exercise, Rest
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Maternal Obesity
Impact of B. Bifidum 900791 Intake on Breast Milk Characteristics of Obese Mothers
Human breast milk harbours a specific microbiota including bacteria from the Lactobacillus and Bifidobacterium genera, that contribute to the bacterial colonization of the infant gut in the post-natal period.
- Trial name
- NCT03913364
- Testing
- Probiotic
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Chile
Adiposity, Breast Feeding
Mother and Infant Study Cohort (MISC)-
This study aims to explore breastfeeding and complementary feeding practices of mothers in the United Arab Emirates (UAE) and its relation to the early life determinants of obesity and non-communicable diseases (NCDs).
- Trial name
- NCT03578094
- Where
- United Arab Emirates
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Obesity, Maternal
The Application of HCG in Luteal Support for Frozen Embryo Transfer in Ovulation Cycle of Obese Women
This study aims to explore whether the application of low-dose HCG in luteal support can improve the pregnancy outcomes of natural cycle frozen embryo transfer in obese patients
- Trial name
- NCT07633002
- Testing
- Human Chorionic Gonadotropin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Shandong University
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Cesarean Section, Surgical Wound Infection
Timing of Cesarean Wound Dressing Removal on Wound Healing in Women With BMI ≥ 30 kg/m²
Cesarean delivery is one of the most common surgical procedures in obstetric care. Women with obesity (body mass index [BMI] of 30 kg/m² or higher) are at increased risk for postoperative wound complications, including surgical…
- Conditions
- Cesarean Section, Surgical Wound Infection, Wound Healing, Obesity
- Trial name
- NCT07846930
- Volunteers
- 726 people
- Sponsor
- Assiut University
Gestational Diabetes Mellitus (GDM), Pregnancy
Gestational Diabetes and Health Outcomes in Mothers and Babies
Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by impaired glucose metabolism and increased insulin resistance.
- Trial name
- GRAZ-GDM (NCT07459907)
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Graz
Gestational Diabetes, Diabetes
Lifestyle Modification to Improve Diet in Women With GDM
The study aims to adapt a lifestyle modification program to engage GDM women early in the postnatal period to evaluate its effectiveness in reducing adiposity and metabolic parameters in the mother.
- Conditions
- Gestational Diabetes, Diabetes, Childhood Obesity, Diabetes Mellitus
- Trial name
- NCT03669887
- Testing
- Lifestyle Modification Program
- Where
- Hong Kong
- Volunteers
- 103 people
- Sponsor
- Chinese University of Hong Kong
Obesity, Obesity, Maternal
Obesity and OSA in Pregnancy
The purposes of this project are 1) to compare the impact of maternal obesity versus excessive gestational weight gain on obstructive sleep apnea (OSA) in obese and non-obese women; 2) to investigate the mechanism(s) by which…
- Conditions
- Obesity, Obesity, Maternal, Obstructive Sleep Apnea, Blood Pressure
- Trial name
- NCT05654259
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Texas Southwestern Medical Center
Maternal Obesity
Balloon to Induce Labor in Generous Women.
The rate of obesity increases continuously in France as in many developing countries.The risk of cesarean delivery is increased in obese compared to normal-weight women and postpartum complications as infections, thromboembolic…
- Trial name
- BIGW (NCT03435458)
- Testing
- Balloon catheter + oral misoprostol, Oral misoprostol alone
- Where
- 18 sites in France, Martinique
- Volunteers
- 429 people
- Sponsor
- University Hospital, Toulouse
Gestational Diabetes, Other "Heavy-For-Dates" Infants
Pregnancy Outcomes and Maternal Insulin Sensitivity
The PROMIS study will focus on maternal insulin sensitivity thourghout pregnancy and postpartum in a moderate to high risk population (BMI ≥25 kg/m2) in developing adverse pregnancy outcomes.
- Conditions
- Gestational Diabetes, Other "Heavy-For-Dates" Infants, Small for Gestational Age Infant, Diabetes Mellitus, Type 2
- Trial name
- PROMIS (NCT04315545)
- Testing
- meal tolerance test
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Endothelial Dysfunction, Childhood Obesity
Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her Offspring
The rising worldwide prevalence of obesity and its subsequently rising incidence of concommitant diseases as diabetes and cardiovascular events impose a defiant obstacle for the health care and associated health care costs of…
- Trial name
- EFFECTOR (NCT02992106)
- Testing
- Parental questionnaires, Blood sample, Urine sample
- Where
- Belgium
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Postpartum Hemorrhage
In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Women with advanced maternal age and morbid obesity, have a higher incidence of labor induction/ augmentation and cesarean section (CS), and are at a greater risk for postpartum hemorrhage (PPH).
- Trial name
- NCT01865669
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Obesity, Labor Complications
Labor Induction and Maternal BMI, Comparison of Different Pre-induction Cervical Ripening Methods
The purpose of this study is to investigate whether mechanical cervical ripening (using the Cook double balloon catheter) is superior or inferior to pharmacological agents (PGE1) in overweight and obese women undergoing labor…
- Trial name
- NCT02223949
- Testing
- Cook double balloon catheter, PGE1 tablet
- Where
- Israel
- Volunteers
- 624 people
- Sponsor
- Hillel Yaffe Medical Center
Obesity, Diabetes, Gestational
Metabolism, Breastmilk, and Microbiome
The objective of this pilot study is to compare breast milk composition in mothers of three different metabolic states (normal weight, obese, and gestational diabetic) and to determine the extent to which breastmilk components…
- Trial name
- NCT03522597
- Where
- United States
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pregnancy Complications, Obesity
Metformin in Obese Non-diabetic Pregnant Women
Obesity is on the rise in all developed countries. Of particular concern is that more young people including children are being recognised as being overweight or obese.
- Trial name
- MOP (NCT01273584)
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 450 people
- Sponsor
- Epsom and St Helier University Hospitals NHS Trust
Gestational Diabetes Mellitus, Medical Nutrition Therapy
Characteristic and Modulation of Gut Microbiota on the Consequences of Pregnancy
Since the incidence of maternal obesity and gestational diabetes mellitus (GDM) is on the rise globally, how to improve the intrauterine environment of the offspring and prevent obesity and metabolic diseases from the early life…
- Conditions
- Gestational Diabetes Mellitus, Medical Nutrition Therapy, Overweight/Obese, Gut Microbiota
- Trial name
- NCT04190511
- Testing
- Prebiotic-containing dairy, Dietary intervention
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Capital Medical University