Clinical trials: Maternal and Neonatal Outcomes
Pregnancy
Assessment of Obstetric, Fetal and Neonatal Risks and Vertical SARS-CoV-2 Transmission During COVID-19 Pandemic
A new coronavirus (COVID-19) highlighted at the end of 2019 in China is spreading across all continents. Most often at the origin of a mild infectious syndrome, associating benign symptoms (such as fever, cough, and headache) to…
- Trial name
- COroFet (NCT04360811)
- Testing
- COVID 19 diagnostic test by PCR
- Where
- France
- Volunteers
- 2,494 people
- Sponsor
- University Hospital, Toulouse
Breastfeeding, Skin to Skin Contact
Effect of Combined Skin-to-Skin Contact and Kangaroo Care on Breastfeeding and Bonding in Cesarean-Born Newborns
This randomized controlled study aims to evaluate the effect of consecutive skin-to-skin contact applied by the mother and father on breastfeeding parameters and parent-infant bonding in babies born by cesarean section.
- Conditions
- Breastfeeding, Skin to Skin Contact, Cesarean Birth, Kangaroo Care
- Trial name
- SSC-CS (NCT07410754)
- Testing
- Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Opioid-use Disorder, Opioid Withdrawal
Maternal Opioid Treatment: Human Experimental Research - Data Yield Appropriate Decisions
This study will compare medically-supervised withdrawal (MSW, 'detoxification') to opioid agonist treatment (OAT, 'maintenance') with buprenorphine for pregnant women with opioid use disorder in terms of maternal, fetal, and…
- Conditions
- Opioid-use Disorder, Opioid Withdrawal, Neonatal Abstinence Syndrome, Neonatal Opioid Withdrawal Syndrome
- Trial name
- MOTHER DYAD (NCT04049799)
- Testing
- Medically-supervised withdrawal, Opioid agonist treatment, Comprehensive clinical care
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- University of Vermont
Premature Birth, Neonatal Hypoglycemia
Higher-Dose Dexamethasone Improves Breathing and Shortens NICU Stay in Preterm Babies
The goal of this observational study was to compare two doses of dexamethasone given to pregnant women at risk of preterm birth. Dexamethasone is a medicine used before birth to help a baby's lungs mature.
- Conditions
- Premature Birth, Neonatal Hypoglycemia, Maternal Infection During Pregnancy, Neurodevelopmental Disorder of Foetus
- Trial name
- NCT07765329
- Testing
- Dexamethasone 12 mg Every 12 Hours, Dexamethasone 6 mg Every 12 Hours
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Stella Maris Women and Children Hospital
Outcome
Intensive Versus Standard Treatment for Spinal Anesthesia-induced Hypotension
The objective of this study is to investigate the impact of varying maternal blood pressure maintenance targets on neonatal outcomes following cesarean section.
- Trial name
- NCT06151483
- Testing
- Alpha-Agonist, α-adrenergic receptor agonist
- Where
- China
- Volunteers
- 1,184 people
- Sponsor
- General Hospital of Ningxia Medical University
Postpartum Urinary Incontinence, Postpartum Depression (PPD)
Prenatal Exercise Including Perineal Massage and Maternal-Neonatal Outcomes
The study is divided into three phases: Phase 1: Baseline survey to obtain an overall understanding of the current situation of voluntary participation in prenatal perineal massage.
- Conditions
- Postpartum Urinary Incontinence, Postpartum Depression (PPD), Neonatal Complications, Gestational Diabetes
- Trial name
- PEPM-RCT (NCT07314502)
- Testing
- Supervised prenatal exercise including antenatal perineal massage
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- South China Normal University
Gestational Diabetes Mellitus With Baby Delivered
Carbohydrate Counting and DASH Intervention and Pregnancy Outcomes Among Women With Gestational Diabetes
Study is an interventional clinical trial. Pregnant women (aged 25-40 years) diagnosed with GDM (by a 75-g oral glucose tolerance test at 24-28 weeks' gestation) will be recruited conveniently from Obstetrics and Gynecology…
- Trial name
- NCT03244579
- Testing
- Dietary Intervention
- Where
- Jordan
- Volunteers
- 180 people
- Sponsor
- University of Jordan
Cesarean Delivery Affecting Fetus or Newborn, Labor (Obstetrics)--Complications
Two Previous Cesarean and Vaginal Birth Before and After Starting Training and Protocols
In 2015 ObGyn Dept of Santo Spirito Hospital in Pescara (Italy) started protocol for previous CS vaginal birth. In 2021 was started a protocol for training on obstetric emergencies and protocol on two previous cesarean was…
- Conditions
- Cesarean Delivery Affecting Fetus or Newborn, Labor (Obstetrics)--Complications, Hemorrhagic Complications
- Trial name
- TOLA2C Train (NCT07258459)
- Testing
- Acceptance, rate of vaginal birth and safety
- Where
- 2 sites in Italy
- Volunteers
- 2,016 people
- Sponsor
- G. d'Annunzio University
Depression, Pregnancy
Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development --- How is Paternal Psychopathology Involved?
This study aims at investigating the effects of maternal depressive symptomatology on pregnancy outcomes and newborn development. How paternal psychopathology is involved in the association will also be explored.
- Trial name
- NCT01280474
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Environmental Exposure, Pregnancy Outcome
The Ma'Anshan Birth Cohort (MABC)
The Ma'anshan Birth Cohort (MABC) is a population-based prospective pregnancy and birth cohort study that aims to explore the early environmental and genetic determinants of maternal and child health, with a focus on health…
- Conditions
- Environmental Exposure, Pregnancy Outcome, Birth Defects, Child Development
- Trial name
- NCT03215368
- Where
- China
- Volunteers
- 3,474 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Polycystic Kidney Disease, Assisted Reproductive Technology
Descriptive Analysis of Preimplantation Genetic Test (PGT)in Couples With Polycystic Kidney Disease (PKD). In the ADPKD Subgroup Evaluation of Outcomes and Complications Comparing Couples in Which the Father is Affected With Couples in Which the Mother is Affected
The goal of this observational study is to evaluate the outcomes of assisted reproductive technology (ART) combined with preimplantation genetic testing for monogenic diseases (PGT-M) in couples affected by or carriers of…
- Conditions
- Polycystic Kidney Disease, Assisted Reproductive Technology, Preimplantation Genetic Testing (PGT)
- Trial name
- PGT-M PKD (NCT07310641)
- Testing
- Assisted reproductive technology and preimplantation diagnosis for monogenic diseases
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Sleep Apnea Syndromes
Snoring in Pregnancy and Adverse Maternal and Fetal Outcomes
The purpose of the study is to determine the prevalence of sleep-disordered breathing in pregnant women during the third trimester of pregnancy and to investigate whether this is associated with high blood pressure in the mother…
- Trial name
- NCT01030003
- Where
- United States
- Volunteers
- 1,685 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Preterm Premature Rupture of Membranes (PPROM)
TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden
The goal of this clinical trial is to learn whether tailoring antibiotic and steroid treatment based on a lab result (interleukin-6, or IL-6) from amniotic fluid can help safely prolong pregnancy in people with preterm premature…
- Trial name
- TAILORED-PROM (NCT07107477)
- Testing
- Tailored antibiotic and steroid therapy based on the IL-6 value in amniotic fluid obtained by amniocentesis in patients with premature rupture of membranes, Antenatal steroids administration, Neuroprotection
- Where
- 3 sites in Czechia
- Volunteers
- 138 people
- Sponsor
- The Central and Eastern European Gynecologic Oncology Group
Abruptio Placentae; Affecting Fetus or Newborn
Normotensive and Hypertensive Placental Abruptions
Placental abruption is a significant cause of both maternal morbidity and neonatal morbidity and mortality. Most abruptions accept to be related to a chronic placental disease process.
- Trial name
- NCT04449601
- Testing
- clinical assesment
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hatice Akkaya
Preeclampsia
Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia
Preeclampsia (PE) complicates 2-8% of pregnancies. It is associated with an increased risk of adverse maternal (death, eclampsia, abruptio placenta, HELLP syndrome) and perinatal (perinatal death, growth restriction, prematurity)…
- Trial name
- HEPEPE (NCT00986765)
- Testing
- Lovenox® (enoxaparin), Aspegic ® (Aspirin)
- Where
- France
- Volunteers
- 257 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia
Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis and Classification of PE Improves Maternal and Perinatal Outcomes in Women With the Suspicion of the Disease
Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality worldwide. The morbidity and mortality of this condition arises from two main causes: 1) the lack of specific and sensible methods for its diagnosis…
- Trial name
- EuroPE (NCT03231657)
- Testing
- Placental biomarkers
- Where
- Spain
- Volunteers
- 2,536 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cesarean Section
Enhanced Recovery Protocol After Cesarean Section
This study aims to evaluate the effectiveness of implementing the Enhanced Recovery After Cesarean (ERAC) protocol on maternal and neonatal outcomes.
- Trial name
- ERAC (NCT07720986)
- Testing
- Enhanced Recovery after Cesarean protocol of Care, Routine hospital care
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Covid19, Pregnancy Related
Safety, Testing/Transmission, and Outcomes in Pregnancies With COVID-19
Pregnant women are a vulnerable and high-risk population, as COVID-19 is associated with an increased risk preterm birth, cesarean section, and maternal critical care.
- Conditions
- Covid19, Pregnancy Related, Maternal Complication of Pregnancy, Coronavirus
- Trial name
- STOPCOVID19 (NCT04718220)
- Testing
- Antibody testing for SARS-CoV-2 IgG, Testing for SARS-CoV-2 RNA, Testing for SARS-CoV-2 IgM/IgG
- Where
- United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Labor Pain
Effectiveness of Using the Swiss Ball in Birth
A randomized clinical trial will be conducted to evaluate the effectiveness of using the Swiss Ball as a resource that reduces the length of labor time.
- Trial name
- BIRTHBALL (NCT04124835)
- Testing
- Swiss Ball, Control Grup
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira