Clinical trials: Mean Arterial Pressure
Brain Injuries
Controlled MAP in the Brain Injury Patient (COMAT Study)
The goal of this randomized controlled trial will be to show that the use of a novel automated system to guide vasopressor administration in brain injury patients will results in more time spent with a mean arterial pressure…
- Trial name
- COMAT (NCT03991052)
- Testing
- EV1000 and closed-loop system, Control group
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation.
- Trial name
- NCT04136080
- Testing
- vasopressors
- Volunteers
- 752 people
- Sponsor
- Fujian Provincial Hospital
Arthroplasty, Replacement, Hip, Anesthesia, Spinal
Goal Directed Fluid Therapy Versus Liberal Fluid Regimen in Primary Elective Hip Artrhoplasty
Patients undergoing elective primary total hip replacement and spinal anesthesia may encounter significant hemodynamic instability.
- Conditions
- Arthroplasty, Replacement, Hip, Anesthesia, Spinal, Hemodynamic Monitoring, Crystalloid Solutions
- Trial name
- NCT04996420
- Testing
- Clearsight non invasive hemodynamic monitoring
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Postmenopausal Symptoms, Aging
Inspiratory Muscle Training in Postmenopausal Women
This study is being conducted by the Department of Kinesiology within the School of Public Health at Indiana University Bloomington.
- Conditions
- Postmenopausal Symptoms, Aging, Obesity
- Trial name
- MRS (NCT06459674)
- Testing
- PrO2 Fit (IMT Trainer)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pulmonary Hypertension
Relation Between Mean Pulmonary Artery Pressure and Pulmonary Acceleration Time and Comparison With Previous Formulae
Since the pulmonary artery hypertension is defined based on MPAP and the two previous formulae relating MPAP and PAT were derived in western population, the investigator planned to conduct a prospective study to derive a new…
- Trial name
- NCT03013062
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hemorrhagic Shock, Trauma
A Comparison of Two Target Mean Arterial Pressures in the Resuscitation of Hypotensive Trauma Patients
The goal of this study will be to determine if a lower than normal blood pressure during surgery for bleeding in the abdomen or chest will result in decreased bleeding and decreased chance of death.
- Conditions
- Hemorrhagic Shock, Trauma, Wounds, Penetrating, Shock, Traumatic
- Trial name
- NCT00459160
- Testing
- Intraoperative Hypotensive Resuscitation
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Baylor College of Medicine
Pulmonary Arterial Hypertension
A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in…
- Trial name
- ARTISAN (NCT05203510)
- Testing
- Parenteral Treprostinil, Oral Treprostinil
- Where
- 28 sites in United States
- Volunteers
- 52 people
- Sponsor
- United Therapeutics
Secondary Peritonitis, Post-induction Hypotension
Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis
This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis.
- Trial name
- NCT07529795
- Testing
- Norepinephrine (0.05 μg/kg/min)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Bach Mai Hospital
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Cerebral Autoregulation, Cardiopulmonary Bypass
Impact of Cardiopulmonary Bypass Flow on Cerebral Autoregulation
Cerebral autoregulation is defined by the capacity of the brain to maintain a constant cerebral blood flow (CBF) despite variations of arterial pressure.
- Conditions
- Cerebral Autoregulation, Cardiopulmonary Bypass, Mean Arterial Pressure
- Trial name
- FLOWMAPCA (NCT05681741)
- Testing
- current versus high pump flow
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Clinique de la Sauvegarde
Thoracic Surgical Procedures, One-lung Ventilation (OLV)
Study of Cardiac Power Index During Supine, Lateral, and Between Left and Right Positions During Two- and One-Lung Ventilation (OLV): Comparison of Hemodynamic Changes After Lung Recruitment Maneuver and Fluid Challenge Among Responders and Non-Responders (SVI, MAP, CPI Changes).
The aim of this trial is to study the changes of the Cardiac Power Index (CPI) during supine and lateral decubitus position in two and one lung ventilation respectively.
- Conditions
- Thoracic Surgical Procedures, One-lung Ventilation (OLV), Hemodynamic Changes
- Trial name
- NCT07037225
- Testing
- Fluid challenge during one-lung ventilation (OLV) in the lateral decubitus position, Hemodynamic monitoring
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maria Fountoulaki
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hypotension
Control Mean Arterial Pressure in the Intensive Care Unit
The goal of this randomized controlled trial is to compare two different strategies of postoperative mean arterial pressure (MAP) management (manual versus automated) in patients who underwent a major surgery and admitted in the…
- Trial name
- COMAP-ICU (NCT04639037)
- Testing
- Automated adjustment of vasopressor, Manual adjustment of vasopressor
- Where
- 2 sites in France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Closed-Loop Communication
COntrolled MAp Trauma Brain Injury (COMAT Study)
The goal of this randomized controlled trial will be to show that the use of a novel automated system to guide vasopressor administration in head trauma injury patients will results in more time spent with a mean arterial…
- Trial name
- COMAT (NCT03792581)
- Testing
- EV1000 and closed-loop system
- Where
- France
- Sponsor
- Erasme University Hospital
Emergence Agitation
Small Doses of Dexmedetomidine for Emergence Agitation
Dexmedetomidine Hydrochloride is a kind of high selectivity alpha 2 agonists adrenaline, can inhibit the activity of sympathetic nerve, and reduce the adverse effects of stress reaction in anesthesia recovery period.Literatures…
- Trial name
- NCT02169843
- Testing
- Sevoflurane, Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tang-Du Hospital
Cardiorespiratory Fitness, Eye Disorders
Ralation Between Cardiorespiratory Fitness and Mean Corrected Intraocular Pressure
Objective: To investigate the association between cardiorespiratory fitness and mean corrected intraocular pressure (IOP) in a normotensive health check-up population, and to evaluate potential differences across age and sex…
- Trial name
- NCT07676747
- Testing
- Mean corrected intraocular pressure (IOP) of both eyes
- Where
- China
- Volunteers
- 2,921 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences
Sepsis, Norepinephrine
Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy:
The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.
- Conditions
- Sepsis, Norepinephrine, Encephalopathy
- Trial name
- NCT05842616
- Testing
- Transcranial doppler pulsatility index guided protocol, Mean arterial blood pressure guided protocol
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Tanta University
Kidney Failure, Acute
Mean Arterial Pressure (MAP) and Renal Perfusion: Evaluation of Critically Ill Patients With Normal Creatinine or Reduced Renal Function
The purpose of this study is to evaluate the renal perfusion depending on the MAP.
- Trial name
- NCT00117416
- Testing
- controlling the MAP
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Pre-Eclampsia, Induction of Labor
Labor Induction in Preeclampsia High-risk Women
Preeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. This pregnancy-specific disorder poses to both pregnant women and their offspring an increased risk of immediate and long-term…
- Trial name
- FORECAST-IOL (NCT05056467)
- Testing
- Induction of Labor
- Where
- 8 sites in China, Hong Kong and 5 more
- Volunteers
- 825 people
- Sponsor
- Chinese University of Hong Kong
Intubation, Nociceptive Pain
NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope
Prospective, randomized and controlled who will be conducted in Maisonneuve-Rosemont hospital and whose objectives are: To observe if the alterations of the NoL index and the standard monitoring (Mean Arterial Blood Pressure and…
- Conditions
- Intubation, Nociceptive Pain, Anesthesia, Laryngoscopy
- Trial name
- NoLint (NCT03277872)
- Testing
- Laryngoscopy with GlideScope (GVL) Blade, Laryngoscopy with MacIntosh (MAC) Blade
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal