Clinical trials: Mechanical Ventilation
ARDS, ARDS, Human
Efficacy and Safety Evaluation of BZ371B in ARDS Patients
The purpose of this study is to evaluate safety, tolerability and efficacy of BZ371B in intubated patients with severe Acute Respiratory Distress Syndrome.
- Conditions
- ARDS, ARDS, Human, Pulmonary Disease
- Trial name
- NCT05384379
- Testing
- Inhaled BZ371B
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- Biozeus Biopharmaceutical S.A.
Respiratory Failure
Sleep Quality in Mechanically Ventilated Patients
Patients requiring mechanical ventilation in the ICU will undergo three consecutive nights of polysomnography to record sleep patterns while receiving three modes of mechanical ventilation; Proportional assist ventilation (PAV)…
- Trial name
- NCT01410149
- Testing
- PAV, PSV, ACV
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs)
Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy
The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy.
- Conditions
- Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs), Prostatic Neoplams, Driving Pressure
- Trial name
- NCT07610824
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Ankara Etlik City Hospital
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intensive Critical Unit, Pneumonia
Evaluation of the Effectiveness and Safety of Supratube Device
Purpose of the trial: Trial design: Two-parallel arm, double-blind, individually randomized controlled trial. Primary endpoint: Clinical evaluation of sinus, oropharyngeal, tracheal, bronchial or pulmonary infections during…
- Conditions
- Intensive Critical Unit, Pneumonia, Aspiration, Prevention and Control
- Trial name
- SUPRANAV (NCT03573609)
- Testing
- Supranav
- Where
- Colombia
- Volunteers
- 108 people
- Sponsor
- Fundación Cardiovascular de Colombia
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiration Disorders
Slope of the Pressure-Time Waveform Predicts Resistance and Compliance in Mechanically Ventilated Subjects
There are two fundamentally different ways to ventilate critically ill patients: constant flow, volume-preset modes (such as volume assist-control) and pressure-preset modes (such as pressure-control and pressure-support).
- Trial name
- NCT00750074
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Gregory A. Schmidt
Surgery, Anaesthesia
Local Assessment of Ventilatory Management During General Anesthesia for Surgery
Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical…
- Conditions
- Surgery, Anaesthesia, Ventilator-Induced Lung Injury, Lung Injury
- Trial name
- LAS VEGAS (NCT01601223)
- Where
- 19 sites in United States, Estonia and 6 more
- Volunteers
- 10,690 people
- Sponsor
- European Society of Anaesthesiology
Children
Safety and Efficacy of Fentanyl Citrate in Children
Title: Safety and efficacy of fentanyl citrate in combination with midazolam in critically ill children with mechanical ventilation Objective: To evaluate the safety and efficacy of fentanyl citrate in combination with midazolam…
- Trial name
- NCT02172014
- Testing
- midazolam and fentanyl citrate infusion, midazolam and normal saline infusion
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Muscle Weakness
Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation
The primary aim of this proposal is to test the effectiveness of NMES in improving functional status and muscle function in patients requirng prolonged mechanical ventilation
- Trial name
- NCT01825135
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- RML Specialty Hospital
Mechanically Ventilated ICU Patients, Diaphragm Excursion
the Effect of Doxapram on Diaphragmatic Excursion(DE) During Weaning From Mechanical Ventilation.
The goal of this clincal trial is to learn if doxapram is effective in weaning in adults on mechanical ventilation. The objectives of this study: Evaluate the effect of doxapram on diaphragmatic function (assessed by DE)during…
- Trial name
- NCT07637149
- Testing
- Doxapram
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Postoperative Complications, Abdominal Surgery
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
- Trial name
- REMAIN-1 (NCT05556174)
- Testing
- periodic lung recruitment maneuvers
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Mechanical Ventilation Complication, Pediatric ALL
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
Critically ill children treated with invasive mechanical ventilation (iMV) in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Intensive Care Unit Acquired Weakness
- Trial name
- NCT04589910
- Testing
- diaphragm thickness and thickening fraction
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
ARDS (Moderate or Severe), Adult Patients
Role of Elastic Power in Acute Respiratory Distress Syndrome
Mechanical ventilation is essential for managing acute respiratory distress syndrome (ARDS), but it can also cause ventilator-induced lung injury (VILI) due to mechanical forces.
- Trial name
- NCT06878313
- Volunteers
- 20 people
- Sponsor
- Hospital El Cruce
ARDS
Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
The use of neuromuscular blocking agents (NMBA) in ARDS patients has not been extensively investigated. The aim of the study is to show a reduction of the mortality rate of ARDS patients.
- Trial name
- NCT00299650
- Testing
- cisatracurium, Cisatracurium besilate
- Where
- 20 sites in France
- Volunteers
- 340 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hyperoxemia, Cerebrovascular Circulation
HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics
This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU).
- Conditions
- Hyperoxemia, Cerebrovascular Circulation, Cerebral Autoregulation, Critical Illness
- Trial name
- HYPER-MIND (NCT07377162)
- Testing
- Normobaric Hyperoxic Stimulus (NBHO)
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Erasme University Hospital
Neuromuscular Diseases, Obesity Hypoventilation Syndrome
Effectiveness Monitoring of Home Non-invasive Mechanical Ventilation by Digital Diagnosis Platform
The main objective will be to determine the effectiveness of home non-invasive ventilation by flow-time and time-pressure curves analysis in a cohort of patients with this treatment by digital diagnosis platform.
- Conditions
- Neuromuscular Diseases, Obesity Hypoventilation Syndrome, Lung Disease, Restrictive
- Trial name
- PRE-HVNI (NCT03085537)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Failure
Comparative Effects on Diaphragmatic Electrical Activity and Respiratory Pattern of Various Levels of Assistance
Exploration of the effects on diaphragmatic electrical activity (EMG) and on respiratory pattern of various level of assistance delivered by the ventilator in intubated spontaneously breathing patients in pressure support (PS)…
- Trial name
- NCT01248845
- Testing
- Titration of various level of assistance
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof. Philippe Jolliet
Mechanical Ventilation Complication, Neurological Complication
The Cerebral-Respiratory Interaction During Spontaneous Breathing Ventilation in Neurosurgical Patients (CeRes-SB)
Mechanical ventilation (MV) is a life-saving supportive therapy and one of the most common interventions implemented in intensive care.
- Conditions
- Mechanical Ventilation Complication, Neurological Complication, Respiratory Complication
- Trial name
- CeRes-SB (NCT05363098)
- Testing
- Mechanically ventilated neurosurgical patients
- Volunteers
- 30 people
- Sponsor
- Uppsala University