Clinical trials: Mechanical Ventilation
COPD, Severe Early-Onset, Ventilatory Failure
Customized Masks in Non-Invasive Mechanical Ventilation
In non-invasive mechanical ventilation (NIMV), the interface is the primary determinant of success, as adherence and quality of therapy mainly depend on it.
- Conditions
- COPD, Severe Early-Onset, Ventilatory Failure, Als, Non Invasive Ventilation
- Trial name
- NCT06215391
- Testing
- 3d printed mask
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario 12 de Octubre
Mechanical Ventilation Complication, Weaning Failure
A Modified Cuff Leak Test and Reintubation in Mechanically Ventilated Patients
We hypothesized that the accuracy of the modified cuff leak test in predicting re-intubation in tracheal intubated patients is better than that of the conventional balloon leak test, thereby further reducing the re-intubation…
- Conditions
- Mechanical Ventilation Complication, Weaning Failure, Airway Obstruction
- Trial name
- NCT05550220
- Testing
- Cuff Leak Test
- Where
- China
- Volunteers
- 586 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Dyspnea During Mechanical Ventilation, Inspiratory Effort
Association of Inspiratory Effort With Dyspnea During Assisted Mechanical Ventilation in Critically Ill Patients
During assisted mechanical ventilation, breathing results from the interaction between the patient and the ventilator. Optimal titration of pressure support is essential to maintain a balance between over-assistance and…
- Conditions
- Dyspnea During Mechanical Ventilation, Inspiratory Effort, Mechanical Ventilation
- Trial name
- NCT07877350
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Crete
Adult Disease, Intensive Care Unit Syndrome
Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
For patients undergoing mechanical ventilation, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased…
- Conditions
- Adult Disease, Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Delirium
- Trial name
- NCT03172897
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University First Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Effects of PEEP and FIO2 in ALI and ARDS
Current American-European Consensus Conference (AECC) definitions for ALI and ARDS are inadequate for inclusion into clinical trials due to the lack of standardization for measuring the oxygenation defect.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Respiratory Failure
- Trial name
- HELP (NCT00435110)
- Testing
- standard ventilatory settings, PEEP and FiO2
- Where
- Spain
- Volunteers
- 178 people
- Sponsor
- Instituto Canario de Investigacion Biomedica
Anxiety
Evaluation of Touch Massage on Anxiety in Critically Ill Patients
Anxiety is a common problem encountered in a about 43 % of critically ill patients. Its occurrence can be related to several causes, mainly dominated by invasive procedures.
- Trial name
- REaLAX (NCT03030482)
- Testing
- touch massage
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Versailles Hospital
Critical Illness, Mechanical Ventilation
Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults
The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit.
- Conditions
- Critical Illness, Mechanical Ventilation, Respiratory Insufficiency
- Trial name
- NCT07734350
- Testing
- Isoflurane, Propofol (Astra-Zeneca)
- Volunteers
- 400 people
- Sponsor
- Hospital H+ Queretaro
Axial Spondyloarthritis (AxSpA)
Multimodal Pulmonary Rehabilitation in Radiographic Axial Spondyloarthritis
This prospective pilot study aims to evaluate the efficacy of a structured 8-week multimodal pulmonary rehabilitation (PR) program specifically designed for patients with radiographic axial spondyloarthritis (r-axSpA).
- Trial name
- PuRe-axSpA (NCT07430189)
- Testing
- Multimodal Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Balikesir University
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sepsis
Project 4B: Lower Extremity Strength Training in ICU Patients
The purpose of this research study is to see if electrical stimulation of the leg muscles will improve strength in patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT02467023
- Testing
- Muscle stimulation with Niveus medical stimulator, measurement of maximal isometric twitch strength, Muscle Biopsy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Chronic Obstructive Pulmonary Disease
Home Mechanical Ventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypercapnic Response
The objective of this study is to evaluate the clinical benefits of home mechanical ventilation associated to oxygen therapy in COPD patients with chronic respiratory failure (CRF) who develop hypercapnia and nocturnal…
- Trial name
- NCT01120574
- Testing
- Home mechanical ventilation
- Where
- Spain
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Mechanical Ventilation Complication, Hyperoxia
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics.
- Trial name
- OXY-BAL (NCT05412810)
- Testing
- oxygen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ohio State University
Respiratory Distress Syndrome, Adult
The Role of Morphological Phenotype in ARDS
Although most of the information focuses on understanding how the ventilator produces lung damage, the pulmonary factors that predispose to ventilator-induced lung injury (VILI) have been less studied.
- Trial name
- MPARDS (NCT04157946)
- Testing
- CT
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital El Cruce
Ventilatory Failure, Cardiac Failure
Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults
The objective of this study is to compare the accuracy and correlation of the capnodynamic method for measuring mixed venous oxygen saturation (SvO2) with the standard reference method (pulmonary artery catheter), with the…
- Conditions
- Ventilatory Failure, Cardiac Failure, Mechanical Ventilation Pressure High
- Trial name
- CAPNO-SVO2 (NCT06632197)
- Volunteers
- 25 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Respiratory Distress Syndrome, Newborn
Feasibility of Mid-frequency Ventilation in Newborns With RDS: Randomized Crossover Pilot Trial
Respiratory distress syndrome (RDS) is the most common respiratory disorder in preterm infants. Despite improved survival of extremely premature infants with RDS, complications related to mechanical ventilation still occur.
- Trial name
- NCT01242462
- Testing
- Conventional Pressure Controlled SIMV, Mid-frequency Ventilation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Critical Illness, Pediatric Critical Illness
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit…
- Conditions
- Critical Illness, Pediatric Critical Illness, Respiratory Failure, Traumatic Brain Injury
- Trial name
- NCT07613918
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Wisconsin, Madison
Diaphragm Injury, Lung Transplant; Complications, Mechanical
Incidence, Risk Factors and Outcomes of Diaphragm Dysfunction After Lung Transplantation
The study is designed to characterize the changes in diaphragm function after lung transplantation.
- Conditions
- Diaphragm Injury, Lung Transplant; Complications, Mechanical, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- RADAR (NCT04103996)
- Testing
- Ultrasound, Respiratory function measurements
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand