Clinical trials: Mechanical Ventilation
Interstitial Lung Disease, Acute Respiratory Failure
NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases
The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in…
- Trial name
- IRAPIDPhysio (NCT06182956)
- Testing
- Noninvasive mechanical ventilation, Nasal high-flow oxygen therapy, Continuous positive airway pressure
- Where
- France
- Volunteers
- 18 people
- Sponsor
- ADIR Association
Mechanical Ventilation
Semi-quantitative Cough Strength Score (SCSS)
Cough strength score will give true prediction of Extubation outcome
- Trial name
- NCT03031860
- Testing
- Semiquantitative Cough Strength Score
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Mechanical Ventilation, Autonomic Nervous System Diseases
Variability Analysis as a Predictor of Liberation From Mechanical Ventilation
The purpose of this study is to evaluate if the variability of biological signals, such as heart rate and temperature, can predict weaning from mechanical ventilation in patients with failure to wean.
- Trial name
- NCT01140750
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Mechanical Ventilation Complication
Thoracic Fluid Content in Prediction of Failure of Weaning From Mechanical Ventilation
This study aims to test the accuracy of the total thoracic fluid content (TFC) measured by cardiometry can predict weaning failure.
- Trial name
- NCT03094390
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
PreTerm Neonate, Extubation Readiness
Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.
The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective…
- Conditions
- PreTerm Neonate, Extubation Readiness, Extubation Failure, Respiratory Morbidity
- Trial name
- CERAINE (NCT06808997)
- Where
- 31 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Burn Injury, Burns
Foreign-National Burn Patients in a Border-Region Burn Center
This retrospective cohort study will evaluate burn patients hospitalized and treated at the Burn Center of Gaziantep City Hospital between October 2023 and June 2026.
- Trial name
- NCT07673796
- Volunteers
- 1,400 people
- Sponsor
- Gaziantep City Hospital
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
ICU Stay, Muscle Atrophy
Weaning Assessment by Peripheral Muscle Ultrasonography
In this study, which aims to investigate the relationship between the weaning process and respiratory muscles-assessed via ultrasonographic measurement of peripheral muscle thickness-in patients over the age of 18 who have been…
- Conditions
- ICU Stay, Muscle Atrophy, Ultrasonography, Weaning Mechanical Ventilation
- Trial name
- NCT07860879
- Testing
- Ultrasonography of peripheral muscle (rectus femoris or vastus intermedius), Ultrasonography of diaphragma
- Volunteers
- 100 people
- Sponsor
- Taksim Egitim ve Arastirma Hastanesi
Respiratory Failure
Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support
A growing body of knowledge has documented that the diaphragm, the primary muscle of breathing, atrophies and weakens within days of instituting mechanical ventilation support.
- Trial name
- NCT01108575
- Testing
- IMST
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Florida
Weaning Failure
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to…
- Trial name
- NCT07003672
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Failure
The Use of Palliative Non Invasive Ventilation in Acute Respiratory Failure. OVNI Study.
The purpose of this study is: to estimate the frequency of the use of non invasive ventilation to estimate the frequency of the use of palliative non invasive ventilation to evaluate the impact of non invasive ventilation to…
- Trial name
- OVNI (NCT01449331)
- Where
- France
- Volunteers
- 1,450 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiration, Artificial, Pleural Effusion
Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated.
- Conditions
- Respiration, Artificial, Pleural Effusion, Ultrasonography
- Trial name
- NCT03394872
- Testing
- Drainage of the pleural effusion
- Volunteers
- 27 people
- Sponsor
- Dokuz Eylul University
Acute Respiratory Distress Syndrome
Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome
BACKGROUND: Currently, there is no proven pharmacologic treatment for patients with the acute respiratory distress syndrome (ARDS).
- Trial name
- DEXA-ARDS (NCT01731795)
- Testing
- Dexamethasone
- Where
- 2 sites in Spain
- Volunteers
- 277 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Hematological Malignancy, Acute Respiratory Failure
Prognosis of Hematological Cancer Patient Underwent Mechanical Ventillation
This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation…
- Conditions
- Hematological Malignancy, Acute Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT02562105
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Position on Premature Infants, Nursing Care
The Effect of Positioning on Comfort, Stress Levels, and Physiological Functions in Premature Infants
A randomized crossover study was made to investigate the effect of different positions on the comfort, stress, and physiological functions of premature infants receiving non-invasive mechanical ventilation in the neonatal…
- Trial name
- NCT06752005
- Testing
- Intervention Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Aydin Adnan Menderes University
Perfusion Pressures, Central Venous Pressure
Sternal Wall Pressure in the Cath Lab
This protocol is a prospective interventional pilot study at the Children's Hospital of Philadelphia to determine whether or not two increments of sternal pressure known to occur during "leaning" in CPR affects hemodynamic…
- Conditions
- Perfusion Pressures, Central Venous Pressure, Cardiac Output, CPR
- Trial name
- NCT01117883
- Testing
- Application of two different sternal weights
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Nasal Injury
The Effect of Hydrocolloid Tape and Facial Massage in Premature Infants During Noninvasive Mechanical Ventilation
The aim of this study is to assess the effect of nasal injury prevention interventions (NIPI) (hydrocolloid tape and facial massage) on nasal septum injury, stress and comfort of premature neonates (28-35 weeks gestation)…
- Trial name
- NIPI (NCT05844345)
- Testing
- Hydrocolloid barrier group, Facial Massage group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ordu University
Infant, Newborn, Diseases, Mechanical Ventilation Complication
Optimising Neonatal Ventilation with Closed-loop Oxygen Control
Ventilated newborns frequently need supplemental oxygen but its use must be monitored carefully as both giving too much or too little oxygen can have harmful effects.
- Trial name
- NCT05657795
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE6000)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College Hospital NHS Trust
Respiration, Artificial
Study of the Combined Influence of Sepsis and Mechanical Ventilation on the Human Diaphragm
The aim of this study is to study the combined impact of mechanical ventilation and sepsis on the human diaphragm in order to establish the neutral, protective or destructive character of mechanical ventilation by studying the…
- Trial name
- SEPTIC (NCT03371602)
- Testing
- surgery, multi-organ sampling
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hospices Civils de Lyon