Clinical trials: Mechanical Ventilation After Surgery
Mechanical Ventilation Complication, Pediatric ALL
Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia
Postoperative pulmonary complications (PPCs) are common in children undergoing general anesthesia and are associated with prolonged stay in the hospital and high costs.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications
- Trial name
- BIG APPLE (NCT06166706)
- Where
- 4 sites in Australia, Italy and 2 more
- Volunteers
- 10,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome
Monitoring in Intensive Care Unit of Neuromuscular Blocking Agents Used for Acute Respiratory Distress Syndrome After Cardiothoracic Surgery
Mortality in Acute Respiratory Distress Syndrome (ARDS) is high (40 to 60 %). Protective mechanical ventilation is the cornerstone of the ARDS therapeutic strategies.
- Trial name
- CURAREA (NCT02546947)
- Testing
- Train of four monitoring
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Postoperative Complications, Abdominal Surgery
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
- Trial name
- REMAIN-1 (NCT05556174)
- Testing
- periodic lung recruitment maneuvers
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Heart-lung Interaction, Right Ventricular Hypertrophy
Cardiopulmonary Effect of Mechanical Ventilation in Children With Right Ventricular Hypertrophy
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Conditions
- Heart-lung Interaction, Right Ventricular Hypertrophy, Postoperative Care, Congenital Heart Disease
- Trial name
- NCT04825054
- Testing
- Mechanical ventilation with NAVA mode, Mechanical ventilation with PCV mode, Mechanical ventilation with PSV mode
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Limin Zhu
Surgery, Mechanical Ventilation Complication
Re-Evaluation of the Effects of High PEEP During General Anesthesia For Surgery (REPEAT)
Aiming to understand the isolated impact of high PEEP in patients undergoing mechanical ventilation for general anesthesia for surgery, three appropriately sized international multicentre randomized controlled trials have been…
- Conditions
- Surgery, Mechanical Ventilation Complication, Pulmonary Complication
- Trial name
- REPEAT (NCT03937375)
- Testing
- High PEEP, Low PEEP
- Where
- 3 sites in Germany, Netherlands and 1 more
- Volunteers
- 3,837 people
- Sponsor
- Hospital Israelita Albert Einstein
Mechanical Ventilation, Following Heart or Abdominal Surgery
Cardiac, Pulmonary and Diaphragm Sonography for the Early Diagnosis of the Different Etiologies Underlying Failure of Weaning From Mechanical Ventilation
Weaning patients off ventilation in an ICU is sometimes difficult, because of three major inter-related etiologies: impaired lung, heart and diaphragm function.
- Trial name
- WEAN US (NCT03261440)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Weaning Mechanical Ventilation, Pediatric Cardiac Surgery
Weaning From Mechanical Ventilation After Pediatric Cardiac Surgery
Weaning from mechanical ventilation post congenital cardiac surgery is often challenging. It is well known that not all patients can be early extubated, although most are suitable for early postoperative weaning and extubating…
- Trial name
- NCT07066748
- Testing
- group P:pressure support ventilation mode, group A:automatic tube compensation (ATC).
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Alexandria University
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Ventilator-Induced Diaphragm Dysfunction
Study of TransAeris® System for Enhanced Recovery After Surgery in France
This study will be conducted as a randomized trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of…
- Trial name
- ERAS (NCT05404477)
- Testing
- TransAeris System
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Synapse Biomedical
Sedation, ICU
RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery
Remimazolam besylate, as a new benzodiazepine drug, showing rapid clearance and moderate distribution of pharmacokinetic changes.
- Conditions
- Sedation, ICU, Remimazolam Besylate
- Trial name
- NCT05606315
- Testing
- Remimazolam Besylate, Propofol, Midazolam
- Where
- 2 sites in China
- Volunteers
- 117 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Patient After Cardiac Valve Surgery, Patient With Prolonged Mechanical Ventilation
The Association Between Intestinal Perfusion and Prolonged Mechanical Ventilation in Patients After Cardiac Valve Surgery
Background This study aimed to confirm that alterations in Doppler parameters of superior mesenteric artery(SMA) blood flow caused by intestinal hypoperfusion are associated with prolonged mechanical ventilation(PMV) in patients…
- Trial name
- NCT05500495
- Testing
- no intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Delayed Extubation, Postoperative Intensive Care
Factors Associated With Late Extubation in Postoperative Patients in the Surgical Intensive Care Unit
Timely removal of a breathing tube after surgery is an important part of recovery for patients admitted to the intensive care unit (ICU).
- Conditions
- Delayed Extubation, Postoperative Intensive Care, Mechanical Ventilation Weaning
- Trial name
- NCT07658456
- Testing
- No Intervention - Retrospective Observational Study
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Kaohsiung Armed Forces General Hospital
Lung Transplant; Complications, Primary Graft Dysfunction
Identifying Optimal PEEP After Lung Transplantation
Lung Transplantation (LuTX) is the curative treatment for selected patients with end-stage lung disease. Primary Graft Dysfunction (PGD), a specific form of respiratory failure occurring within the first 72 hours after graft…
- Trial name
- PEEP-LuTX (NCT05691205)
- Testing
- PEEP
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- Policlinico Hospital
Obese
Mechanical Ventilation in Obese Surgical Patients
The purpose of this study is to evaluate whether an intraoperative positive end-expiratory pressures (PEEP) setting strategy aimed at minimizing the mechanical power delivered to the lungs via transpulmonary pressure improves…
- Trial name
- NCT07774065
- Testing
- Standard PEEP (8 cmH₂O)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Post-operative Neurosurgery
Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation
Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output.
- Trial name
- NCT02450279
- Testing
- technetium-99m - Diethylenetriaminepentaacetic acid, Vibrating-mesh nebulizer, Jet Nebulizer
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Respiration, Artificial, Positive-Pressure Respiration
VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU
Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU).
- Conditions
- Respiration, Artificial, Positive-Pressure Respiration, Postoperative Complications (Cardiopulmonary), Postoperative Complications
- Trial name
- VENTICRIT (NCT07646249)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Lung Diseases
Protective Versus Conventional Mechanical Ventilation for Peripheral Vascular Surgery.
Background and goal of the study: Postoperative complications following major surgeries are associated with a significant increase in costs and mortality.
- Trial name
- NCT03616210
- Testing
- Protective ventilation
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiac Surgery, Mechanical Ventilation After Surgery
Prevalence and Clinical Impact of Airway Opening Pressure in Post-Cardiac Surgery Patients
Airway opening pressure is a key parameter in assessing respiratory mechanics. Current practice primarily relies on indirect assessments of lung mechanics, but growing evidence suggests that direct airway opening pressure…
- Trial name
- NCT07189026
- Testing
- Airway opening pressure
- Where
- Canada
- Volunteers
- 196 people
- Sponsor
- Laval University
Postoperative Atelectasis, Postoperative Pulmonary Atelectasis
Lung Ultrasound Assessment of Postoperative Atelectasis After Mechanical Ventilation With Minimum Driving Pressure
Brief summary The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure…
- Conditions
- Postoperative Atelectasis, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications (PPCs), Lung Ultrasonography Score
- Trial name
- NCT07186920
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras