Clinical trials: Mechanical Ventilation Strategies
Respiratory Failure, All Intubated Patients
Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients.
- Trial name
- NCT01472302
- Testing
- Adaptive Support Ventilation, Pressure Controlled Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 229 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Weaning Patients
Transfusion Strategies in Weaning Patients
The aim of this study is to determine, whether a liberal transfusion strategy is helpful to liberate patients from prolonged invasive mechanical ventilation.
- Trial name
- WTT (NCT01256645)
- Testing
- blood transfusion
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Krankenhaus Kloster Grafschaft
Acute Respiratory Failure
Pilot Study on Pairing Sedation Strategies and Weaning
A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first).
- Trial name
- NCT02219659
- Testing
- Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- MemorialCare Health System
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Mechanical Ventilation Pressure High, Critical Illness
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all.
- Trial name
- NCT06393179
- Testing
- pressure-volume curve with a low-flow insufflation of 5 L/min
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Southeast University, China
Prevention of Delirium
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if…
- Trial name
- INASED (NCT04341350)
- Testing
- Propofol + analgesic drug, Isoflurane + analgesic drug
- Where
- 12 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Mechanical Ventilation Complication
Lowering PEEP: Weaning From High PEEP Setting
The perfusion of the deeply different areas coexisting in ARDS lung generates two type of venus-admixure : true shunt and shunt effect.
- Trial name
- NCT04429399
- Testing
- decrease the positive end expiratory pressure (PEEP), mechanical features assessment, shunt assessment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bari
Hypertension, Pulmonary Arterial, Out-Of-Hospital Cardiac Arrest
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)
Background: For patients with out-of-hospital cardiac arrest (OHCA) at the intensive care unit (ICU), oxygen therapy plays an important role in post resuscitation care.
- Conditions
- Hypertension, Pulmonary Arterial, Out-Of-Hospital Cardiac Arrest, Intensive Care Unit, Oxygen Therapy
- Trial name
- RELIEPH (NCT05029167)
- Testing
- Restrictive PaO2, Low normal MAP, Liberal PaO2
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Southern Denmark
ARDS, Acute Respiratory Failure
Generating Evidence in ECMO Ventilation Strategies
The goal of this pilot clinical trial is to test if ICU level ventilator protocols are appropriate interventions to study differences in ventilator strategies for patients with acute respiratory failure supported by VV-ECMO.
- Trial name
- GENIE-Vent (NCT05708365)
- Testing
- Standard-Lung Protective Ventilation, Ultra-Lung Protective Ventilation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Lung Collapse
The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
- Trial name
- N-LAT-EIT (NCT04235231)
- Testing
- Bed tilting, Body positioning
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Regional Hospital Liberec
ARDS Due to COVID-19
Ventilator Strategies in ICU Patients With COVID-19 - a National-wide Retrospective Observational Study.
Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events.
- Trial name
- NCT05102630
- Where
- 2 sites in Denmark
- Volunteers
- 1,193 people
- Sponsor
- University of Southern Denmark
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Patients With Hospital-acquired Pneumonia
VAPERO is a randomized, unblinded, controlled study to measure the impact of a strategy based on the Unyvero® multiplex PCR test on the adjustment of antimicrobial therapy in patients suspected with ventilator-associated or…
- Trial name
- VAPERO (NCT03711331)
- Testing
- FilmArray® Pneumonia panel plus, Standard care
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Lille
Weaning Failure, COPD Exacerbation
Comparison of Two Ventilator Mode During the Night: New Strategy of Mechanical Ventilation Weaning
The purpose of the study is to compare pressure controlled continuous mandatory ventilation versus pressure support ventilation during the night for weaning to mechanical ventilation in chronic obstructive pulmonary disease…
- Trial name
- REVENTIL (NCT01573481)
- Testing
- pressure support ventilation, Pressure controlled ventilation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Kidney Failure, Mechanical Ventilation Strategies
Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients
This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE/PASP ratio, and its association with acute kidney injury (AKI) progression in mechanically…
- Conditions
- Acute Kidney Failure, Mechanical Ventilation Strategies, Right Ventricular (RV) Dysfunction, Critical Illness
- Trial name
- NCT07836387
- Testing
- Driving Pressure-Guided Ventilator Optimization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nardin Aymn Boshra
Acute Respiratory Distress Syndrome, Acute Lung Injury
Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
The aim of this multicenter randomized controlled trial is to compare the impact on mortality of patients mechanically ventilated for acute lung injury or acute respiratory distress syndrome of two strategies for setting…
- Trial name
- ExPress (NCT00188058)
- Testing
- Setting of positive end-expiratory pressure
- Where
- 46 sites in France
- Volunteers
- 768 people
- Sponsor
- University Hospital, Angers
Pressure Ulcer, Respiratory Distress Syndrome, Acute
Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study
Prone position (PP) is standard of care for mechanically ventilated patients with severe acute respiratory distress syndrome in the intensive care unit (ICU). Recommendations suggest PP durations of at least 16 hours.
- Conditions
- Pressure Ulcer, Respiratory Distress Syndrome, Acute, Hypoxemic Respiratory Failure, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05124197
- Testing
- prone position
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Hôpital Louis Mourier
Daily Sedative Interruption, Sedation Strategies
Pilot Study for Sedation Interruption in Children
The purpose of this study is to estimate the hypothesized benefit of sedation interruption protocol on mechanical ventilation duration and PICU length of stay.
- Conditions
- Daily Sedative Interruption, Sedation Strategies, Sedation Protocols, Mechanical Ventilation
- Trial name
- NCT02426320
- Testing
- Sedation Interruption Protocol, Standard Sedation Protocol
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Davinia Withington
Respiratory Failure, Acute Respiratory Distress Syndrome
Respiratory System Compliance Guided VT in Moderate to Severe ARDS Patients
The Acute Respiratory Distress Syndrome (ARDS) is one of common clinical critically diseases. In the United States, the incidence of ARDS reaches 31%, which is one of the main causes of death in patients.
- Trial name
- NCT02814994
- Testing
- tidal volume guided by respiratory system compliance, low tidal volume
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Southeast University, China
Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction
Prophylactic Use of APRV Before Extubation in Morbidly Obese Patients After Cardiac Surgery.
Morbidly obese patients undergoing open heart surgery are at increased risk of breathing problems after removal of the breathing tube due to reduced lung function and chest wall restriction following surgery.
- Conditions
- Morbid Obesity in Cardiac Surgery Patients, Postoperative Respiratory Dysfunction, Mechanical Ventilation Strategies
- Trial name
- APRV-OBESE-CS (NCT07409324)
- Testing
- Airway Pressure Release Ventilation (APRV), Conventional Lung-Protective Mechanical Ventilation
- Volunteers
- 180 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome, Mechanical Ventilation
Mechanical Ventilation Strategy for Coronavirus Disease 2019 (COVID-19)
This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute…
- Conditions
- Respiratory Distress Syndrome, Mechanical Ventilation, SARS (Severe Acute Respiratory Syndrome)
- Trial name
- COVEN (NCT04497454)
- Testing
- EIT-Group, ARDSNet
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- University of Sao Paulo General Hospital