Clinical trials: Mechanical Ventilation Weaning
Respiratory Failure, Functional Performance
Correlations Among Functional Performance, Muscle Strength and Weaning Rate in Mechanically Ventilated Patients
To assess the correlations among the physical functional performance, muscle strength, respiratory muscle strength and the ventilator weaning rate.
- Conditions
- Respiratory Failure, Functional Performance, Physical Therapy
- Trial name
- NCT03894293
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation
Endotracheal Suctionning During Positive Pressure Extubation in ICU
The aim of this clinical trial is to evaluate endotracheal suctioning during positive pressure extubation in mechanically ventilated adult patients (over 18 years old) in the intensive care unit (ICU).
- Conditions
- Mechanical Ventilation With Oral Intubation, Weaning Invasive Mechanical Ventilation, Oxygen Saturation Measurement, Rox Index
- Trial name
- INTENTION (NCT07130123)
- Testing
- Suctionning extubation, No suctionning Extubation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Respiratory Failure
Pilot Study on Pairing Sedation Strategies and Weaning
A three-arm, randomized, pilot study, to assess the feasibility for the analgesia-first sedation (AFS) study arm/intervention (Fentanyl push first).
- Trial name
- NCT02219659
- Testing
- Sedation Protocol with Daily Interruption, Sedation Protocol Without Daily Interruption, Fentanyl Push First
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- MemorialCare Health System
Mechanical Ventilation Complication, Diaphragm Injury
Effect of Diaphragm Stimulation During Surgery
During major surgical procedures general anesthesia is used to make the patient unconscious. General anesthesia insures that the patient is unaware of any pain caused by surgery.
- Trial name
- NCT03303040
- Testing
- Electrical stimulation of hemidiaphragm
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Inadequate or Impaired Breathing Pattern or Ventilation
Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure
The purpose of this study is to determine whether helmet is effective as device for noninvasive positive pressure ventilation in the weaning from mechanical ventilation.
- Trial name
- NCT01322659
- Testing
- Helmet, Endotracheal tube
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Padova
COVID-19, ARDS, Human
WeanINg From Mechanical Ventilation for ARDS CovId-19 Patients Guided by Combined Thoracic UltraSound.
The most feared complication of COVID-19 infection is the occurrence of an acute respiratory distress syndrome (ARDS) that requires ICU admission and prolonged mechanical ventilation in more than 2% of the affected patients.
- Conditions
- COVID-19, ARDS, Human, Mechanical Ventilation
- Trial name
- INVICTUS (NCT04372680)
- Testing
- CTUS examination
- Where
- 2 sites in France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Toulouse
Respiratory Insufficiency Requiring Mechanical Ventilation
Evaluation on the Effect of Acupuncture and Neuromuscular Electrical Stimulation on Mechanical Ventilation Patients
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for…
- Trial name
- NCT05221710
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Mechanical Ventilation Weaning, Spontaneous Breathing Trial
High-Flow Tracheal Oxygen During Spontaneous Breathing Trial
The purpose of this study is to find out whether high-flow tracheal oxygen (HFTO) delivered at flows greater than 60 L/min can increase end-expiratory lung volume (EELV) in intubated patients during a spontaneous breathing trial…
- Conditions
- Mechanical Ventilation Weaning, Spontaneous Breathing Trial, High Flow Oxygen Therapy
- Trial name
- HFTO-SBT (NCT07864415)
- Testing
- T-piece, HFTO 50, washout, HFTO 70, washout, PSV., T-piece, HFTO 70, washout, HFTO 50, washout, PSV.
- Volunteers
- 30 people
- Sponsor
- Argentinian Intensive Care Society
Communication
Electrolarynx for Enabling Communication in the CHrOnically Critically Ill (EECCHO)
All critically ill patients receiving mechanical ventilation experience a period of inability to speak due to the need for cuffed endotracheal or tracheostomy tubes.
- Trial name
- EECCHO (NCT05604079)
- Testing
- Electrolarynx
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Michael Garron Hospital
Critical Care, Weaning
Heart Rate Variability During Weaning From Mechanical Ventilation
The discontinuation of mechanical ventilation (MV) and the recovery of spontaneous breathing can lead to important cardiovascular alterations due to changes in the intrathoracic pressure.
- Trial name
- NCT00851825
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm
Several types of spontaneous breathing trials (SBTs) have been proposed to evaluate when a patient is ready to be weaned from the ventilator based on breathing pattern measurements.
- Trial name
- OWED (NCT02539732)
- Where
- 3 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Myocardial Ischaemia During Surgery
Monitoring of Heart to Guide Myocardial Injury Patients to Wean From Ventilation
The goal of this prospective randomized controlled clinical trail is to explore the value of integrating continuous cardiac index variability indicators with existing weaning standards to guide perioperative myocardial injury…
- Trial name
- NCT06240104
- Testing
- cardiac output index monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Weaning Failure
Rest After Spontaneous Breathing Trial for Prevention of Post-extubation Failure
To evaluate if a rest period before extubation after a successful SBT trial could reduce the extubation failure rate.
- Trial name
- NCT01915563
- Testing
- REST
- Where
- Spain
- Volunteers
- 470 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Weaning of Mechanical Ventilation
Arterial Blood Gases in Weaning of Mechanical VEntilation
Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before…
- Trial name
- WAVE (NCT05801692)
- Testing
- Weaning of mechanical ventilation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Weaning From Mechanical Ventilation, Weaning Failure
Characterization of Weaning Practices in ICUs of Global South Countries
This is a prospective observational study to be conducted in intensive care units of Global South countries. Patients on mechanical ventilation for more than 12 hours who have initiated the weaning process and for whom the…
- Conditions
- Weaning From Mechanical Ventilation, Weaning Failure, Weaning From Mechanical Ventilation, Extubation
- Trial name
- NCT07337408
- Where
- Brazil
- Volunteers
- 900 people
- Sponsor
- Hospital do Coracao
Respiratory Insufficiency, Ventilator Weaning
Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
The choice of the sedation protocol has a massive impact on the duration of mechanical ventilation and the timing of extubation. Many sedation protocols are described in the literature.
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Analgesics, Opioid
- Trial name
- TOES (NCT04204967)
- Testing
- Fentanyl Transdermal System, Remifentanil
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Weaning From Mechanical Ventilation
Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning
The aim of this study is to assess the validity of the diaphragmatic thickening Fraction measured by ultrasound as a predictor for successful weaning from mechanical ventilation.
- Trial name
- NCT06465082
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Mansoura University Hospital
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto