Clinical trials: Mechanical Ventilation Weaning
Mechanical Ventilation Weaning, Chronic Disease
Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities
The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier.
- Trial name
- NCT07594418
- Testing
- Phenotype-Guided Weaning Strategy, Standard Care
- Volunteers
- 1,380 people
- Sponsor
- Southeast University, China
Critical Care, Weaning
Cardiorespiratory Changes in Patients Being Weaned Off Mechanical Ventilation
The objective of this study was to analyze changes in cardiac function using Doppler echocardiogram in critical patients during weaning from mechanical ventilation using two different weaning methods (pressure support and T-tube)…
- Trial name
- NCT00852891
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Cardiometry, Thorathic Fluid Content
The Validity of Thorathic Fluid Content as Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients
Introduction Weaning from mechanical ventilation (MV) could be described as the process of removing ventilator support. Weaning from MV often implies two separate but closely linked views of care, elimination of MV of any…
- Conditions
- Cardiometry, Thorathic Fluid Content, Weaning From Mechanical Ventilation
- Trial name
- NCT06685406
- Testing
- Thorathic fluid content measurement by cardiometry
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Bronchopulmonary Dysplasia
Pressure-Sensing Mattresses and Mechanical Ventilation Weaning in Neonatal
This study aims to explore the correlation between using ballistocardiography for monitoring respiration and heart rate in neonates under invasive and non-invasive respiratory support.
- Trial name
- NCT06579157
- Testing
- Pressure-Sensing Mattresses
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University
Respiratory Failure
Comparison Between Two Methods of Spontaneous Breathing Trial (SBT)
To compare a new mode of mechanical ventilation, Automatic Tube Compensation (ATC) with a traditional one, Continuous Positive Airway Pressure(CPAP), on its effectiveness for detecting patients no longer needing mechanical…
- Trial name
- NCT00400881
- Testing
- automatic tube compensation
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Muscle Weakness Condition, Mechanical Ventilation Complication
Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure
The handgrip strength (HGS) will be measured with a digital dynamometer. Three measurements will be taken, whose average of the three measurements will be collected.
- Conditions
- Muscle Weakness Condition, Mechanical Ventilation Complication, Weaning Failure
- Trial name
- NCT03991702
- Testing
- diagnostic test
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Respiratory Failure, Respiration, Artificial
Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode.
- Trial name
- NCT04140682
- Testing
- PAV+ mode, PSV mode
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Mechanical Ventilation Complication
Mechanical Ventilator Weaning in Chronically Ventilated Patients
Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be removed gradually.
- Trial name
- NCT06976554
- Testing
- weaning
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Ventilator Weaning, Respiration, Artificial
A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score
Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability…
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Failure, Extubation Readiness
- Trial name
- REXs (NCT07098611)
- Where
- 7 sites in Chile, Egypt and 4 more
- Volunteers
- 470 people
- Sponsor
- Medipol University
Critical Illness, ICU Acquired Weakness
Muscle Evaluation Using Ultrasound in the Critically Ill
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay.
- Trial name
- ULTRAMUSCLE (NCT03550222)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Failure
Weaning From Mechanical Ventilation Guided by Lung Ultrasound (Brazilian WEANLUS)
The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a "clinical optimization" protocol as…
- Trial name
- WEANLUS-BR (NCT01966861)
- Testing
- weaning guided by LUS (lung ultrasound)
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- D'Or Institute for Research and Education
Mechanical Ventilation Complication
Thoracic Fluid Content in Prediction of Failure of Weaning From Mechanical Ventilation
This study aims to test the accuracy of the total thoracic fluid content (TFC) measured by cardiometry can predict weaning failure.
- Trial name
- NCT03094390
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Cairo University
Acute Mechanical Ventilatory Failure
Weaning From Prolonged Mechanical Ventilation
Patients requiring the use of artificial ventilation (also called mechanical ventilation) for more than 21 days account for more than 37% of all ICU costs.
- Trial name
- NCT01541462
- Testing
- Weaning
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- RML Specialty Hospital
Neurological Diseases or Conditions
Weaning From Mechanical Ventilation in Neurological Patients
After a period of mechanical ventilation, a spontaneous breathing trial is performed before extubation in order to assess the patient's ability to breathe.
- Trial name
- NCT03128086
- Testing
- Protocol-directed weaning
- Where
- Spain
- Volunteers
- 94 people
- Sponsor
- Hospital General Universitario de Castellón
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Weaning Failure
Peripheral Perfusion Index in Weaning From Mechanical Ventilation
Peripheral perfusion index (PPI) is variable measured by Radical-7 (Masimo) device and reflects the ratio between pulsatile and non-pulsatile portions of peripheral circulation.
- Trial name
- NCT03974568
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Cairo University