Clinical trials: Mechanical Ventilation Weaning
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
Adult Patients Ventilated More Than 48 h
Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy
Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.
- Trial name
- WIN IN WEAN (NCT02123940)
- Testing
- lung ultrasound score
- Where
- France
- Volunteers
- 483 people
- Sponsor
- University Hospital, Clermont-Ferrand
Tracheostomy Patients, Tracheostomy Decannulation
Tracheostomy Practice in Adult Intensive Care Units
ON TRACH is an international, multicentre, observational study with the aim of characterising the timing and practice of tracheostomy insertion, management, weaning and longer-term outcomes of these patients, in intensive care…
- Conditions
- Tracheostomy Patients, Tracheostomy Decannulation, Intensive Care (ICU)
- Trial name
- ON TRACH (NCT07769021)
- Where
- 13 sites in United States, Brazil and 6 more
- Volunteers
- 2,500 people
- Sponsor
- Royal College of Surgeons, Ireland
Respiratory Failure
Multicenter, Multinational, Clinical Trial of the Performance of RESPINOR DXT to Identify Patients at Increased Risk of Weaning Failure
The study will be a multicenter, multinational, prospective single arm blinded study to validate DXT's performance to identify patients at increased risk of weaning failure during the spontaneous breathing trial (SBT).
- Trial name
- DE-RISK WF (NCT04696406)
- Testing
- RESPINOR DXT
- Where
- 9 sites in France, Italy and 1 more
- Volunteers
- 193 people
- Sponsor
- Respinor AS
Critical Illness Polyneuropathies
Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness
The researchers intend to investigate possible anabolic effects of bi-weekly exogenous testosterone administration during intensive care unit (ICU) stay for up to 8 weeks.
- Trial name
- RAS-ICU (NCT03038919)
- Testing
- Testosterone cypionate, Standard nutrition and physical therapy at ICU
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Prolonged Mechanical Ventilation
Effects of Continuous Mobility Training in Prolonged Mechanical Ventilation
Background: The exercise intervention can help participants with prolonged mechanical ventilation improve ventilator weaning; however, the content of exercise intervention is diverse and inconsistent.
- Trial name
- NCT05688267
- Testing
- Continuous Mobility Training, Usual Care
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Taichung Tzu Chi Hospital
Hypnosis, Weaning Mechanical Ventilation
Hypnosis During Mechanical Ventilation Weaning
Hypnosis is defined as an altered state of consciousness characterized by an increased susceptibility to suggestion. It is a technique commonly used in the medical field, primarily for the management of pain and anxiety.
- Conditions
- Hypnosis, Weaning Mechanical Ventilation, Hypnosis During Weaning From Invasive Mechanical Ventilation
- Trial name
- HYPREA (NCT07518498)
- Testing
- Hypnosis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Weaning Failure
Improving Our Understanding of Respiratory Muscle Training to Facilitate Weaning From Mechanical Ventilation in the ICU
Mechanical ventilation is a life-saving treatment frequently applied in intensive care unit (ICU). Nonetheless, by putting at rest the respiratory muscles, it can lead to respiratory muscle weakness and atrophy, which are…
- Trial name
- TrainToWean (NCT04658498)
- Testing
- Procedure: Usual Care (UC), Procedure: UC + HI-IMT
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Weaning Failure, Mechanical Ventilation
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in ICU Patients
The Value of Repeated BIOMarker Measurements During an SBT to Predict EXtubation Failure in Mechanically Ventilated ICU Patients
- Conditions
- Weaning Failure, Mechanical Ventilation, Spontaneous Breathing Trial, Extubation Failure
- Trial name
- BIOMEXIC (NCT05637099)
- Where
- Netherlands
- Volunteers
- 181 people
- Sponsor
- Henrik Endeman
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova
High Velocity Nasal Insufflation, Simple Oxygen
A Randomized Clinical Trial for Predictors of Successful Extubation of Pediatric Patients With or Without High Velocity Nasal Insufflation
A randomized clinical trial about predictors of successful extubation of pediatric patients from mechanical ventilation either on High Velocity Nasal Insufflation or simple nasal oxygen and comparing the outcome
- Conditions
- High Velocity Nasal Insufflation, Simple Oxygen, Weaning Criteria
- Trial name
- NCT07383051
- Testing
- Comparing the outcome of pediatric patients after successful weaning on either High Velocity Nasal Insufflation or simple oxygen, comparing High Velocity Nasal Insufflation to simple oxygen after successful weaning of pediatric patients
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Weaning, Mechanical Ventilation
Effect of High Flow Oxygen Therapy in Spontaneous Breathing Trial on Weaning in Mechanical Ventilated Patients
This clinical trial is aimed to show a spontaneous breathing trial using high flow oxygen therapy may lower weaning failure rate and reintubation rate than using T-piece.
- Conditions
- Weaning, Mechanical Ventilation, Extubation
- Trial name
- HOST (NCT03929328)
- Testing
- High flow oxygen therapy in spontaneous breathing trial
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Sang-Min Lee
Functional Test, COPD, Neuromuscular Disorders, Mechanical Ventilation, Weaning, Disability
MIND Score for Prolonged Mechanical Ventilation
It was decided to develop a comprehensive disability score specifically designed for patients receiving prolonged mechanical ventilation (PMV); the collection of information included in the score should not impose any further…
- Trial name
- MIND (NCT02255058)
- Testing
- No intervention
- Where
- 5 sites in Argentina, Colombia and 1 more
- Volunteers
- 129 people
- Sponsor
- Linde AG
Critical Illness, Intensive Care Units (ICUs)
Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing…
- Conditions
- Critical Illness, Intensive Care Units (ICUs), Weaning Failure, Mechanical Ventilation
- Trial name
- SERA-Effort (NCT07109570)
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Weaning From Mechanical Ventilation, Extubation
T-piece Versus Pressure-support for the Spontaneous Breathing Trial
The main objective will be to compare the number of ventilator-free days within the 28 days following the first spontaneous breathing trial between strategies of extubation performing spontaneous breathing trials with T-piece…
- Trial name
- TiP-Ex (NCT04227639)
- Testing
- T-piece trial, Pressure-support trial
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Ventilatory Defect
Specific Inspiratory Muscle Training (SIMT)in the Patients With Ventilatory Dependence
Prolong mechanical ventilation cause to respiratory muscle weakness and high risk to weaning failure,the investigators hypothesize that 1.
- Trial name
- SIMT (NCT00792441)
- Testing
- intervention group
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Saikaew Chuachan
Chronic Obstructive Pulmonary Disease
Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway.
- Trial name
- NAVASYNC (NCT01042080)
- Testing
- NAVA, Expiratory trigger (ET)
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Hôpital Européen Marseille
Wounds and Injuries, Ventilation Therapy; Complications
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications.
- Trial name
- NCT06339073
- Testing
- mechanical ventilation
- Where
- China
- Volunteers
- 1,023 people
- Sponsor
- Jinling Hospital, China
Mechanical Ventilation Complication
Effects of Growth Hormone on Difficult Ventilator Weaning Patients
Major abdominal surgeries may be followed by postoperative pulmonary complications (PPCs). These complications are common and can cause significant morbidity and mortality.
- Trial name
- NCT03717168
- Testing
- Recombinant human growth hormone, Control
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Weaning Failure
Role of Non-invasive Mechanical Ventilation and Diuretics in Improving Weaning Outcome of Patients With High Lung Ultrasound Score
patients who succeeded in SBT with high lung scores by ultrasound, non-invasive ventilation, and diuretic may have a role.
- Trial name
- NCT05617989
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University