Clinical trials: Mechanical Ventilation Weaning
Obesity, Obesity With Complications
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful.
- Conditions
- Obesity, Obesity With Complications, Weaning From Mechanical Ventilation in Care Unit, Dyspnea
- Trial name
- WEAN OBESE (NCT06867354)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wounds and Injuries, Ventilation Therapy; Complications
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications.
- Trial name
- NCT06339073
- Testing
- mechanical ventilation
- Where
- China
- Volunteers
- 1,023 people
- Sponsor
- Jinling Hospital, China
Mechanical Ventilation Complication
Mechanical Ventilator Weaning in Chronically Ventilated Patients
Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be removed gradually.
- Trial name
- NCT06976554
- Testing
- weaning
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Respiratory Distress Syndrome (RDS)
Using Artificial Intelligence Models for Predicting The Need for Intubation and Successful Weaning From Mechanical Ventilation in ICU Patients
Using artificial intelligence (AI) approach to build a model to determine the optimal timing of intubation and optimal timing of weaning from MV for ICU patients, and compare outcomes with these which depend on clinicians…
- Trial name
- NCT07065838
- Volunteers
- 600 people
- Sponsor
- Assiut University
Acute Respiratory Failure
NAVASET: Nava Level Titration Using Comfort Scales
Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable.
- Trial name
- NCT02133443
- Testing
- PSV - pressure support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Caen
Prolonged Mechanical Ventilation
Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation
This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the…
- Trial name
- NCT05634135
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Taiwan University Hospital
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Respiratory Physiotherapy in Mechanical Ventilation
This study aimed to evaluate the effect of respiratory physiotherapy that is breathing exercise during weaning on ventilated patients in ICU.
- Trial name
- NCT04670939
- Testing
- breath exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Muğla Sıtkı Koçman University
Ventilator Weaning
Echocardiographic Detection of Extravascular Lung Water Increase During Weaning From Mechanical Ventilation
Switching from positive airway pressure ventilation to spontaneous ventilation during weaning from mechanical ventilation, pulmonary edema may occur and in this case, doppler echocardiographic (U/S) indices of cardiac dysfunction…
- Trial name
- ECHOBAG (NCT02412202)
- Testing
- Monitoring of pulmonary oedema induced by weaning from mechanical ventilation
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Communication
Electrolarynx for Enabling Communication in the CHrOnically Critically Ill (EECCHO)
All critically ill patients receiving mechanical ventilation experience a period of inability to speak due to the need for cuffed endotracheal or tracheostomy tubes.
- Trial name
- EECCHO (NCT05604079)
- Testing
- Electrolarynx
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Michael Garron Hospital
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Weaning Failure
Predictive Analysis Software for Successful Weaning From Ventilator of Patients
Making a weaning decision for a patient on a mechanical ventilator is an important clinical issue. The most common index to predict successful weaning is the rapid shallow breathing index (RSBI), however, the accuracy of RSBI to…
- Trial name
- NCT02915458
- Where
- Taiwan
- Volunteers
- 188 people
- Sponsor
- Chang Gung Memorial Hospital
Weaning Failure
Lung Ultrasound for Predicting Outcome of Weaning From Mechanical Ventilation
Lung aeration loss can be measured via lung ultrasound, it is a non-invasive, bed side procedure, which can be performed rapidly and facilitates a dynamic assessment of lung aeration.
- Trial name
- NCT03880864
- Testing
- Ultrasound
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin
Tracheostomy Patients, Tracheostomy Decannulation
Tracheostomy Practice in Adult Intensive Care Units
ON TRACH is an international, multicentre, observational study with the aim of characterising the timing and practice of tracheostomy insertion, management, weaning and longer-term outcomes of these patients, in intensive care…
- Conditions
- Tracheostomy Patients, Tracheostomy Decannulation, Intensive Care (ICU)
- Trial name
- ON TRACH (NCT07769021)
- Where
- 13 sites in United States, Brazil and 6 more
- Volunteers
- 2,500 people
- Sponsor
- Royal College of Surgeons, Ireland
Mechanical Ventilation Weaning
Autonomic Modulation in Patients Undergoing Assisted Mechanical Ventilation: Comparison Between PAV+ and PSV
The aim of the study is to investigate autonomic modulation in terms of heart rate variability (i.e., HRV) in patients undergoing assisted mechanical ventilation in PSV mode, compared to patients assisted in PAV+ mode.
- Trial name
- NCT06590311
- Testing
- Heart Rate Variability
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- University of Roma La Sapienza
Mechanical Ventilation Weaning
Ultrasound Diagnostic for Diaphragmatic Dysfunction in Reanimation
Extubation is a crucial step when patients are being weaned from mechanical ventilator support. Indeed, the patient has to face an increasing burden imposed to the ventilation system.
- Trial name
- ECHODIAPH II (NCT02883465)
- Testing
- Diaphragmatic ultrasound
- Where
- 3 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Pneumonia, Invasive Mechanical Ventilation
Ultrasound Evaluation of Respiratory Muscles During Mechanical Ventilation Weaning in ICU Patients
Patients with pneumonia who require invasive mechanical ventilation in the intensive care unit (ICU) often experience difficulties during the process of being separated from the breathing machine (weaning).
- Conditions
- Pneumonia, Invasive Mechanical Ventilation, Weaning From Mechanical Ventilation in Care Unit, Respiratory Muscle Dysfunction
- Trial name
- NCT07405567
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Prolonged Mechanical Ventilation
Diaphragm Dysfunction During Prolonged Mechanical Ventilation
The transition to unassisted breathing after invasive ventilation often proves challenging. Persistent ventilator dependence predisposes patients to nosocomial complications and death and increases the economic burden of critical…
- Trial name
- DD-SRPR (NCT03676998)
- Testing
- Measurement of diaphragm function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris