Clinical trials: Mechanical Ventilation Weaning
Chronic Obstructive Pulmonary Disease
Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway.
- Trial name
- NAVASYNC (NCT01042080)
- Testing
- NAVA, Expiratory trigger (ET)
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Hôpital Européen Marseille
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients
Evaluation of the Clinical and Prognostic Value of Non-invasive Analysis of Mandibular Movements (MM) as a Marker of Inspiratory Effort in the Spontaneously Breathing Intensive Care Patient
Evaluate the performance for measuring inspiratory effort of non-invasive mandibular movement analysis compared to the reference technique oesophageal pressure (PES) variation, in ventilated and spontaneously breathing Intensive…
- Conditions
- Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients, Invasive Mechanical Ventilation
- Trial name
- MM-ICU (NCT07441590)
- Testing
- 2 recording phases
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Respiratory Failure, Weaning Failure
Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA
the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation.
- Trial name
- InterThick (NCT05990348)
- Testing
- difficult weaning patients
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Respiratory Insufficiency Requiring Mechanical Ventilation
Evaluation on the Effect of Acupuncture and Neuromuscular Electrical Stimulation on Mechanical Ventilation Patients
Acupuncture is a treatment intervention used globally for a wide variety of disorders. Its efficacy has been established over the course of 3000 years, originating in Asia and diversifying worldwide.The scientific basis for…
- Trial name
- NCT05221710
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Acute Respiratory Distress Syndrome (ARDS), Pneumonia
Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.
Pre-market clinical trial on 81 aldults participants to evidence safety and performance of the non-CE-marked medical device INBENTUS VERSATILE ventilator.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease), Postoperative Respiratory Distress
- Trial name
- NCT07432191
- Testing
- INBENTUS VERSATILE
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Iconic Solutions By Murcia SL
Mechanical Ventilator Weaning, Respiratory Muscle Training
Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training
Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure.
- Trial name
- FLEX (NCT05710432)
- Testing
- Quasi-Isometric Neck Flexion, Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Prolonged Mechanical Ventilation
Diaphragm Dysfunction During Prolonged Mechanical Ventilation
The transition to unassisted breathing after invasive ventilation often proves challenging. Persistent ventilator dependence predisposes patients to nosocomial complications and death and increases the economic burden of critical…
- Trial name
- DD-SRPR (NCT03676998)
- Testing
- Measurement of diaphragm function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation
Weaning From Mechanical Ventilation Guide by Assessment of Lung Tidal Distribution With EIT
To evaluate whether EELI, RVD, GI were good predictor for weaning from mechanical ventilation
- Trial name
- NCT03118804
- Testing
- Assessment of Lung Tidal Distribution With EIT
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Southeast University, China
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Weaning Failure of Mechanical Ventilation
Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU)…
- Trial name
- NCT07073976
- Testing
- Transthoracic Echocardiography (TTE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Prolonged Mechanical Ventilation, Ventilator Weaning
Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged…
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Ventilator Dependent, Exoskeleton Device
- Trial name
- NCT07445035
- Testing
- lower-limb exoskeleton, Standard medical treatment
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Fu Jen Catholic University
Ventilator Weaning
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation
A UK multi-centre cluster randomised controlled trial to determine if a protocol-based intervention incorporating coordinated care with greater nursing involvement to managing sedation and ventilator weaning can reduce the…
- Trial name
- SANDWICH (NCT03673683)
- Testing
- SANDWICH protocol, Usual care
- Where
- 17 sites in United Kingdom
- Volunteers
- 10,498 people
- Sponsor
- Queen's University, Belfast
Ventilator Weaning, Hand Strength
Handgrip Strength Value in Predicting Mechanical Ventilation Weaning
The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
- Conditions
- Ventilator Weaning, Hand Strength, Respiration
- Trial name
- GRIPWEAN (NCT02946502)
- Testing
- Handheld dynamometry (handgrip strength)
- Where
- France
- Volunteers
- 261 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ICU Stay, Muscle Atrophy
Weaning Assessment by Peripheral Muscle Ultrasonography
In this study, which aims to investigate the relationship between the weaning process and respiratory muscles-assessed via ultrasonographic measurement of peripheral muscle thickness-in patients over the age of 18 who have been…
- Conditions
- ICU Stay, Muscle Atrophy, Ultrasonography, Weaning Mechanical Ventilation
- Trial name
- NCT07860879
- Testing
- Ultrasonography of peripheral muscle (rectus femoris or vastus intermedius), Ultrasonography of diaphragma
- Volunteers
- 100 people
- Sponsor
- Taksim Egitim ve Arastirma Hastanesi
Respiration, Artificial, Ventilators, Mechanical
Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation
The objective of this study is to evaluate the efficacy of the VentFree Respiratory Muscle Stimulator (VentFree) in critically ill adult patients who require invasive mechanical ventilation, when compared to sham.
- Trial name
- PREVENT (NCT05759013)
- Testing
- Breath synchronized abdominal FES
- Where
- 27 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Liberate Medical
Acute Respiratory Failure
Continuous Positive Airway Pressure and Oxygen Concentration on Measurement of Rapid Shallow Breathing Index
To compare the rapid shallow breathing index (RSBI) values, the incidence of adverse reactions, and the predictive accuracy measured under 5 different ventilator strategies in the same patient group.
- Trial name
- NCT00632320
- Where
- Taiwan
- Volunteers
- 98 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Weaning From Mechanical Ventilation in Care Unit
Prediction of the Spontaneous Breathing Test Success Using Biosignal and Biomarker in Critical Care Unit by a Machine Learning Approach
Context: Several authors have been interested in applying Artificial Intelligence (AI) to medicine, using various Machine Learning (ML) techniques: managing septic shock, predicting renal failure...
- Trial name
- NCT05886803
- Testing
- Spontaneous ventilation test
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nice