Clinical trials: Mechanical Ventilator Care
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
Mechanical Ventilation Complication, Ventilator Associated Pneumonia
Semirecumbent Position by Mechanical Ventilation
It's based in an observational trial in mechanical ventilated patients. The investigators assess the head of bed elevation angle in the routine treatment of the unit.
- Conditions
- Mechanical Ventilation Complication, Ventilator Associated Pneumonia, Compliance, Treatment
- Trial name
- NCT04149665
- Testing
- simple blind observation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Bürgerspital Solothurn
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Ventilator-Associated Pneumonia
The Effect of Solutions Used in Oral Care on Preventing Ventilator-Associated Pneumonia.
The goal of this clinical trial is to learn about effects of chlorhexidine gluconate, sodium bicarbonate, ozonated water and hypochlorous acid solutions used in oral care of patients on mechanical ventilation support on…
- Trial name
- NCT06118242
- Testing
- Use of oral care solutions
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Aydin Adnan Menderes University
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Ventilator Associated Pneumonia, Oral Hygiene
Implementation and Evaluation of Revised Protocols for Oral Hygiene for Mechanically Ventilated Patients
The primary objective of this study is to evaluate the effectiveness and feasibility of the implementation of revised standards of care for oral hygiene (SAGE Q-care q2 Oral Cleansing and Suctioning System with and without…
- Trial name
- NCT01657396
- Testing
- Standard Oral Hygiene, SAGE Q-care q2, SAGE Q-care q2 with Chlorhexidine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Calgary
Pain, Sedation
Effect of Maternal Voice on Pain, Sedation, and Physiological Parameters in Mechanically Ventilated Children
Children in the pediatric intensive care unit often experience pain and stress from medical procedures, even while sedated. This study will test whether playing a recording of the child's mother's voice helps reduce pain and the…
- Conditions
- Pain, Sedation, Mechanical Ventilation
- Trial name
- NCT07753486
- Testing
- Recorded Maternal Voice
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- TC Erciyes University
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Dyspnea
Sensory and Emotional Modulation of Dyspnea Under Artificial Ventilation in the Intensive Care Unit
Rationale: Half of the patients receiving mechanical ventilation in the intensive care unit (ICU) have moderate to severe dyspnea.
- Trial name
- Sensopnée2 (NCT04815317)
- Testing
- Auditive stimulation, Sensitive stimulation, Auditory control
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Ventilator-Associated Pneumonia, Severe Pneumonia
Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia
This randomized controlled trial evaluated the clinical effect of fiberoptic bronchoscopy in the management of adult patients with severe ventilator-associated pneumonia (VAP).
- Conditions
- Ventilator-Associated Pneumonia, Severe Pneumonia, Critical Illness
- Trial name
- NCT07149909
- Testing
- Other (Conventional Therapy), Fiberoptic Bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Neoplasms, Musculoskeletal Diseases
Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients.
- Conditions
- Neoplasms, Musculoskeletal Diseases, Digestive System Diseases, Respiratory Tract Diseases
- Trial name
- NCT00606788
- Testing
- SmartCare/PS (Automated Weaning), Conventional weaning
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Ventilator Weaning, Airway Extubation
Can a Pain Monitor Predict When Postoperative Intensive Care Unit Patients Are Ready to Breathe on Their Own? A Pilot Study
The goal of this observational study is to learn if a chest monitor that tracks heart rhythm can help predict whether adults on a breathing machine after surgery will be able to breathe on their own once the breathing tube is…
- Conditions
- Ventilator Weaning, Airway Extubation, Respiration, Artificial
- Trial name
- NCT07771101
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Intensive Care Unit Syndrome
The Effect of Prone Position Use Ventilator-Associated Pneumonia in Intensive Care Patients
The aim of this experimental study was to investigate the effect of prone position use on ventilator values, blood gas and ventilator-associated pneumonia in intensive care unit patients.
- Trial name
- prone (NCT05760716)
- Testing
- practicing prone position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul Arel University
Tracheostomy
Consequence of Open Versus Closed Tracheostomy Immediately After Decannulation
Tracheostomy is performed for prolonged mechanical ventilation. Ineffective bandaging following decannulation leaves the tracheostomy wound unsealed, reducing pulmonary function, coughing ability, and voice quality, ultimately…
- Trial name
- NCT06138093
- Testing
- Sealing device, No device
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
Mechanical Ventilation Complication
Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies
Patient-ventilator asynchronies can occur as a result of a mismatch between neural (patient) and ventilator inspiratory and expiratory phases.
- Trial name
- Pmus (NCT05144607)
- Testing
- Muscle Pressure curve (Pmus)
- Where
- Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Respiratory Insufficiency, Ventilation Therapy; Complications
KAP Asynchrony Survey
The investigators developed a web-based survey to assess knowledge, attitudes and practice of health care professionals about patient-ventilator asynchrony.
- Conditions
- Respiratory Insufficiency, Ventilation Therapy; Complications, Ventilators, Mechanical, Respiration, Artificial
- Trial name
- KAPA (NCT03439683)
- Testing
- Survey about patient-ventilator asynchrony
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Critical Illness, Respiratory Insufficiency
Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients
The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult…
- Conditions
- Critical Illness, Respiratory Insufficiency, Ventilator Weaning, Weaning Failure of Mechanical Ventilation
- Trial name
- NCT07571317
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Istanbul University - Cerrahpasa
Ventilator Induced Diaphragm Dysfunction, Respiratory Muscle Weakness
Standardization of IMT Dosage (UTIT) in Mechanical Ventilation.
Respiratory muscle weakness prolongs mechanical ventilation (MV) and delays weaning. Currently, there is no standardized dosage for Inspiratory Muscle Training (IMT) in the ICU.
- Conditions
- Ventilator Induced Diaphragm Dysfunction, Respiratory Muscle Weakness, Mechanical Ventilation Weaning
- Trial name
- UTIT-IMT (NCT07761468)
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital H+ Queretaro