Clinical trials: Mechanical Ventilator Weaning
Ventilator Weaning
A Protocol to Wean From Noninvasive Mechanical Ventilation
The investigators use a protocol to wean from noninvasive mechanical ventilation.
- Trial name
- NCT01535755
- Testing
- protocol, physician's orders
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Duan jun
Ventilator Lung
Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients
This is a prospective, single-center, observational study to describe characteristics of weaning process and factors associated with duration of weaning and its outcomes in all consecutive adult (aged 19 years and older) patients…
- Trial name
- NCT05134467
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Ventilator Weaning, Respiration, Artificial
Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training
The TONES trial aims to evaluate the neuroventilatory efficiency (NVE = tidal volume / peak voltage of diaphragm contraction) measured during a zero-assist manoeuvre (ZAM, i.e. with PEEP but without pressure support).
- Conditions
- Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure
- Trial name
- TONES (NCT05380687)
- Testing
- Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Antwerp
Neoplasms, Musculoskeletal Diseases
Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients.
- Conditions
- Neoplasms, Musculoskeletal Diseases, Digestive System Diseases, Respiratory Tract Diseases
- Trial name
- NCT00606788
- Testing
- SmartCare/PS (Automated Weaning), Conventional weaning
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Pediatric Liver Transplantation, Weaning From Mechanical Ventilation
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing…
- Trial name
- NAVIGATE (NCT04792788)
- Testing
- Weaning from mechanical ventilation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Ventilator Weaning, Hand Strength
Handgrip Strength Value in Predicting Mechanical Ventilation Weaning
The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
- Conditions
- Ventilator Weaning, Hand Strength, Respiration
- Trial name
- GRIPWEAN (NCT02946502)
- Testing
- Handheld dynamometry (handgrip strength)
- Where
- France
- Volunteers
- 261 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation
Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation
The goal of this clinical trial is to test the impact of serum phosphorus level optimization on weaning from mechanical ventilation in adult ICU patients in Alexandria University Hospitals.
- Trial name
- NCT05682846
- Testing
- Sodium glycerophosphate pentahydrate solution
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Alexandria University
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Mechanical Ventilation, Weaning Failure
Effect of Hypophosphatemia on Neuro-excursion Efficiency During Mechanical Ventilator Weaning
Hypophosphatemia is a common phenomenon in the ICU, and several retrospective studies have shown that hypophosphatemia is associated with prolonged mechanical ventilation in ICU patients.
- Conditions
- Mechanical Ventilation, Weaning Failure, Hypophosphatemia
- Trial name
- NCT06754670
- Testing
- Sodium Glycerophosphate 216 MG/ML
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College
Respiratory Failure
Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial
The purpose of this study is to determine whether lansoprazole administered nasogastrically is effective for stress ulcer prophylaxis in respiratory intensive care unit.
- Trial name
- NCT00708149
- Testing
- lansoprazole OD
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Far Eastern Memorial Hospital
Ventilator Weaning
Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation
1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant.
- Trial name
- NCT03433105
- Where
- Taiwan
- Volunteers
- 157 people
- Sponsor
- National Taiwan University Hospital
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Weaning
Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning in Difficult-weaning Patients
The aim of this study is to facilitate weaning by switching between invasive and noninvasive ventilation in difficult-weaning patients.
- Trial name
- NCT02921347
- Testing
- switching between invasive and noninvasive ventilation
- Where
- China
- Volunteers
- 83 people
- Sponsor
- Chongqing Medical University
Acute Respiratory Failure
Research on Respiratory Support Decision-Making for Mechanically Ventilated ICU Patients Based on a Physiological World Model
Mechanical ventilation is essential for ICU patients with respiratory failure, yet ventilator adjustment and weaning decisions remain experience-dependent and highly variable.
- Trial name
- NCT07834671
- Where
- China
- Volunteers
- 4,232 people
- Sponsor
- Ruijin Hospital
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Diaphragm Issues, Ventilator-Induced Lung Injury
Randomized Study to Investigate the Safety and Performance of Diaphragm Stimulation Coupled With Mechanical Ventilation
This study is a randomized prospective, single-center feasibility study of the use and benefits of NeuRx DPS in patients undergoing tracheostomy for failure to wean.
- Conditions
- Diaphragm Issues, Ventilator-Induced Lung Injury, Tracheostomy
- Trial name
- NCT04457427
- Testing
- NeuRx Diaphragm Pacing System (DPS)
- Where
- Turkey (Türkiye)
- Sponsor
- Synapse Biomedical
Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence
Shenfu Injection for the Prevention and Treatment of Ventilator Dependence in Mechanically Ventilated Patients
This multicenter randomized controlled trial aims to evaluate the efficacy of Shenfu Injection in preventing and treating ventilator dependence and ventilator-induced diaphragm dysfunction (VIDD) in critically ill adult patients…
- Conditions
- Ventilator-induced Diaphragm Dysfunction, Ventilator Dependence, Ventilator Weaning
- Trial name
- NCT07880977
- Testing
- Shenfu Injection, 5% glucose injection
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Ventilator Weaning, Alkalosis, Metabolic
Acetazolamide Facilitates Ventilator Weaning
Metabolic alkalosis(MA) is common metabolic disorder in ICU setting. MA could be cause of weaning failure or delay by depression of respiratory center.
- Trial name
- NCT01131377
- Testing
- acetazolamide, Saline
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Mechanical Ventilator Weaning
D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success…
- Trial name
- NCT07590362
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University