Clinical trials: Mechanical Ventilator Weaning
Weaning Failure, Complication of Respirator [Ventilator]
Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation
Prolongation of mechanical ventilation poses serious personal and financial threats to healthcare consumers. The investigators objectives are create and implement an multidisciplinary evidenced-based ventilator-weaning protocol…
- Trial name
- NCT01482429
- Testing
- Multidisciplinary weaning-ventilator protocol
- Where
- Brazil
- Volunteers
- 235 people
- Sponsor
- Federal University of Uberlandia
Ventilator Weaning
Transcutaneous Carbon Dioxide Pressure (tcPCO2) Monitoring for the Prediction of Extubation Failure in the ICU
Difficult weaning from ventilation and extubation failure are major issues in intensive care, concerning 30% and 12% of patients respectively.
- Trial name
- tcPCO2 (NCT02894177)
- Testing
- tcPCO2 measurement
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Versailles Hospital
Weaning From Mechanical Ventilation
Comparison of the Impact of Three Programs of Inspiratory Muscles.
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- PREDRIC (NCT02855619)
- Testing
- Martin, Cader, EDRIC
- Where
- 2 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux
Weaning Failure
Predictive Analysis Software for Successful Weaning From Ventilator of Patients
Making a weaning decision for a patient on a mechanical ventilator is an important clinical issue. The most common index to predict successful weaning is the rapid shallow breathing index (RSBI), however, the accuracy of RSBI to…
- Trial name
- NCT02915458
- Where
- Taiwan
- Volunteers
- 188 people
- Sponsor
- Chang Gung Memorial Hospital
PMV
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function
The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean.
- Trial name
- NCT05295381
- Testing
- cough machine (CM), abdominal weight training (AWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Liu Shih Feng
Respiratory Failure
Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.
The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.
- Trial name
- NCT01757093
- Testing
- Automatic Tube Compensation plus CPAP, Continuous Positive Airway Pressure
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Respiratory Insufficiency, Weaning, Ventilator
Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction
Mechanical ventilation is essential in the management of critically ill patients, but deciding the proper time to wean and extubate remains a significant challenge.
- Conditions
- Respiratory Insufficiency, Weaning, Ventilator, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT07144878
- Testing
- Parasternal Intercostal Ultrasound and RSBI Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Mechanical Ventilation, Mechanical Ventilator Weaning
Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI)
The Rapid Shallow Breathing Index (RSBI) is the ratio between respiratory rate (RR) and tidal volume (VT). It is routinely used to predict mechanical ventilation weaning outcome in ICU patients.
- Conditions
- Mechanical Ventilation, Mechanical Ventilator Weaning, Extubation, Diaphragm Ultrasound
- Trial name
- CODEX (NCT03479047)
- Testing
- assess diaphragmatic displacement (DD) using ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Respiratory Failure, Communication Disorders
Early Speaking Valve in Ventilator Weaning: Effects on Communication, Depression, and Quality of Life
This study evaluates the impact of early tracheostomy speaking valve intervention on communication ability, depression levels, and quality of life in ventilator-dependent patients during the weaning phase.
- Conditions
- Respiratory Failure, Communication Disorders, Depression, Quality of Life
- Trial name
- NCT07005596
- Testing
- Passy-Muir Speaking Valve, Standard Non-Verbal Communication Methods
- Volunteers
- 70 people
- Sponsor
- Far Eastern Memorial Hospital
Mechanical Ventilator Weaning, Mechanical Ventilation
Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment
"Weaning from mechanical ventilation is a crucial step in the intensive care unit. Several factors complicate weaning and increase the risk of failure.
- Trial name
- PREDEXTUB (NCT06450678)
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
Respiration, Artificial
Ventilatory Weaning Guided by a New Index
Mechanical ventilation (MV) is an essential therapy for patients with acute respiratory failure. The ventilatory weaning process should be started when the precipitating causes of the use of the ventilatory prosthesis are…
- Trial name
- NCT04512677
- Testing
- Timed Inspiratory Effort (TIE index)
- Where
- 2 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Universidade Federal Fluminense
Ventilator Weaning, Ultrasound
Weaning Ventilator Using Heart, Lung And Diaphragm Ultrasound
Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. Failure to wean is known to be connected with heart, lung, and diaphragm problems.
- Trial name
- NCT06321848
- Where
- Vietnam
- Volunteers
- 199 people
- Sponsor
- Hanoi Medical University
Mechanical Ventilator Weaning, Respiratory Muscle Training
Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training
Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure.
- Trial name
- FLEX (NCT05710432)
- Testing
- Quasi-Isometric Neck Flexion, Inspiratory Muscle Training
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Ventilators, Mechanical, Work of Breathing
Effort of Breathing Guided Ventilator Protocol
This pilot study tests the feasibility of using a computerized ventilator management protocol seeking to encourage lung protective ventilation during the acute phase of ventilation, and esophageal manometry based titration of…
- Trial name
- EOBvent (NCT02989246)
- Testing
- Ventilator protocol, Esophageal Catheter
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Los Angeles
Ventilator Weaning, Respiratory Failure
Assessments of Diaphragm-pleural Mechanics During the Weaning From Prolonged Mechanical Ventilation
Weaning failure from mechanical ventilator is commonly seen in respiratory failure and increases duration of ventilator use, ICU stay, ventilator associated pneumonia and even mortality.
- Trial name
- NCT03842280
- Testing
- Diaphragm ultrasound assessment & Esophageal pressure measurement
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Respiratory Insufficiency
Clinical Trial of a Computer-driven Weaning System for Patients Requiring Mechanical Ventilation
The purpose of this study is to compare the efficacy of a computer-assisted ventilator weaning system (Drager Smartcare) to our current standard of care in the medical intensive care unit.
- Trial name
- NCT00606554
- Testing
- Computer-assisted weaning program, Standard of Care weaning
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Boston Medical Center
Ventilator Weaning
Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicenter Prospective Cohort Study
The goal of this observational study is to learn about the effect of the occlusion pressure during the first 100 miliseconds (P01) over the extubation failure in participants receiving mechanical ventilation for acute respiratory…
- Trial name
- NCT06662201
- Where
- Argentina
- Volunteers
- 256 people
- Sponsor
- Argentinian Intensive Care Society
Ventilator Weaning
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation
A UK multi-centre cluster randomised controlled trial to determine if a protocol-based intervention incorporating coordinated care with greater nursing involvement to managing sedation and ventilator weaning can reduce the…
- Trial name
- SANDWICH (NCT03673683)
- Testing
- SANDWICH protocol, Usual care
- Where
- 17 sites in United Kingdom
- Volunteers
- 10,498 people
- Sponsor
- Queen's University, Belfast
Mechanical Ventilation Weaning Phase in Children
Safety and Feasibility Study of a Mechanical Ventilation Computerized Protocol: Intellivent
The present protocol will demonstrate the safety, feasibility and efficacy of a newly computerized protocol integrated into a ventilator: S1 ventilator (Hamilton Medical).
- Trial name
- CloserPed (NCT01095406)
- Testing
- S1 ventilation
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital