Clinical trials: Mechanical Ventilator Weaning
Hypercapnic Respiratory Failure, Weaning Failure
Weaning From Noninvasive Ventilation
Noninvasive ventilation (NIV) weaning strategies differ considerably from one another. These strategies have yet not been compared to each other.
- Conditions
- Hypercapnic Respiratory Failure, Weaning Failure, Noninvasive Ventilation
- Trial name
- WEANIV (NCT02845076)
- Testing
- Protocol for weaning of noninvasive ventilation
- Where
- 8 sites in Italy, Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Baskent University
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
Ventilator Weaning
Automatic Control of Pressure Support Ventilation in Surgical Intensive Care Units
This bicentric, randomized, controlled trial examines the effectiveness of an automatic control of pressure support ventilation (SmartCare/PS) in critically ill patients.
- Trial name
- ASOPI (NCT00445289)
- Testing
- SmartCare/PS
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Schleswig-Holstein
Critical Illness Myopathy, Respiration, Artificial
Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients
Subjects in MV will be included, divided into 3 groups: (a) Control Group (CG), (b) Stimulation of Quadriceps (Quadriceps Group - QG), (c) Stimulation of Diaphragm (Diaphragm Group - DG).
- Trial name
- NCT03352102
- Testing
- Electrical stimulation
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Pericles Almeida Delfino Duarte
Acute Respiratory Failure
Research on Respiratory Support Decision-Making for Mechanically Ventilated ICU Patients Based on a Physiological World Model
Mechanical ventilation is essential for ICU patients with respiratory failure, yet ventilator adjustment and weaning decisions remain experience-dependent and highly variable.
- Trial name
- NCT07834671
- Where
- China
- Volunteers
- 4,232 people
- Sponsor
- Ruijin Hospital
Ventilator Weaning, Child
The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning
To correlate the data obtained by Electrical impedance tomography (EIT) during the spontaneous breathing trials (SBT) on a T-piece, in children, with failure in the trial and Extubation failure.
- Conditions
- Ventilator Weaning, Child, Spontaneous Breathing Trial, Electrical Impedance Tomography
- Trial name
- NCT04011852
- Testing
- Electrical Impedance tomography
- Where
- Brazil
- Volunteers
- 83 people
- Sponsor
- University of Sao Paulo General Hospital
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Acute Hypoxemic Respiratory Failure
Noninvasive Positive Pressure Ventilation for Early Extubation of Acute Hypoxemic Respiratory Failure
Acute hypoxaemic respiratory failure (AHRF) refers to pathological states in which arterial blood oxygenation is severely impaired，and which need invasive positive pressure ventilation (IPPV) as respiratory support technique in…
- Trial name
- NPPV (NCT01151501)
- Testing
- noninvasive positive pressure ventilation
- Where
- China
- Sponsor
- Beijing Chao Yang Hospital
Pediatric Liver Transplantation, Weaning From Mechanical Ventilation
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing…
- Trial name
- NAVIGATE (NCT04792788)
- Testing
- Weaning from mechanical ventilation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Spinal Cord Injury, Respiratory Insufficiency
A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries
The study will compare outcomes between individuals with sub-acute, ventilator-dependent tetraplegia using high (20 cc/kg) vs. low (10 cc/kg) tidal volumes during mechanical ventilator support.
- Trial name
- NCT00412308
- Testing
- Tidal volume used in mechanical ventilation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Craig Hospital
Ventilator Weaning
A Protocol to Wean From Noninvasive Mechanical Ventilation
The investigators use a protocol to wean from noninvasive mechanical ventilation.
- Trial name
- NCT01535755
- Testing
- protocol, physician's orders
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Duan jun
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Electromyography, Ventilator Weaning
Analysis on the Fatigue and Electromyographic Activation on the Mechanical Ventilation Weaning
This study aims to evaluate respiratory muscle activation and fatigue during the mechanical ventilation weaning process using surface electromyography (sEMG).
- Conditions
- Electromyography, Ventilator Weaning, Critical Illness, Intensive Care
- Trial name
- AFAEMG (NCT07387731)
- Testing
- Sponteneous breathing test in T-tube, Sponteneous breathing test in suport ventilation (PSV)
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Rio Grande do Sul
Ventilator Weaning
Association Between P0.1 and Extubation Failure in Adult Patients With Acute Hypoxemic Respiratory Failure. A Multicenter Prospective Cohort Study
The goal of this observational study is to learn about the effect of the occlusion pressure during the first 100 miliseconds (P01) over the extubation failure in participants receiving mechanical ventilation for acute respiratory…
- Trial name
- NCT06662201
- Where
- Argentina
- Volunteers
- 256 people
- Sponsor
- Argentinian Intensive Care Society
Acute Lung Injury, Adult Respiratory Distress Syndrome
Variable Pressure Support Trial
In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort.
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, at Least 24 h of Controlled Mechanical Ventilation
- Trial name
- ViPS (NCT01769053)
- Testing
- Variable Ventilation
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Technische Universität Dresden
Neoplasms, Musculoskeletal Diseases
Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients.
- Conditions
- Neoplasms, Musculoskeletal Diseases, Digestive System Diseases, Respiratory Tract Diseases
- Trial name
- NCT00606788
- Testing
- SmartCare/PS (Automated Weaning), Conventional weaning
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Ventilator Weaning
Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation
1.Research hypothesis: during weaning patient from prolonged mechanical ventilation, if the work load caused by weaning was below the patient's AT, oxygen uptake will be constant.
- Trial name
- NCT03433105
- Where
- Taiwan
- Volunteers
- 157 people
- Sponsor
- National Taiwan University Hospital
Ventilator Weaning, Respiratory Failure
Assessments of Diaphragm-pleural Mechanics During the Weaning From Prolonged Mechanical Ventilation
Weaning failure from mechanical ventilator is commonly seen in respiratory failure and increases duration of ventilator use, ICU stay, ventilator associated pneumonia and even mortality.
- Trial name
- NCT03842280
- Testing
- Diaphragm ultrasound assessment & Esophageal pressure measurement
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Ventilator Weaning
Physiologic Effects of High-flow Nasal Cannula Versus Standard Oxygen Therapy Postextubation in Critically Ill Patients
High-flow nasal cannula (HFNC) is a rather novel system to provide oxygen therapy, which provides flows up to 60 liters/minute (LPM) of heated and humidified gas through nasal prongs.
- Trial name
- NCT04711759
- Testing
- High flow nasal cannula, Standard oxygen therapy
- Where
- Chile
- Volunteers
- 26 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Mechanical Ventilation, Mechanical Ventilator Weaning
Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI)
The Rapid Shallow Breathing Index (RSBI) is the ratio between respiratory rate (RR) and tidal volume (VT). It is routinely used to predict mechanical ventilation weaning outcome in ICU patients.
- Conditions
- Mechanical Ventilation, Mechanical Ventilator Weaning, Extubation, Diaphragm Ultrasound
- Trial name
- CODEX (NCT03479047)
- Testing
- assess diaphragmatic displacement (DD) using ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Régional d'Orléans