Clinical trials: Mechanically Ventilated Patients
Pneumonia
Pulmonary-Specific Enteral Nutrition in Mechanically Ventilated Patients With Pneumonia
Pneumonia is a major cause of critical illness and respiratory failure, particularly among patients requiring invasive mechanical ventilation.
- Trial name
- NCT07892521
- Testing
- Pulmonary-Specific Enteral Nutrition, Standard Hospital Enteral Nutrition
- Where
- Indonesia
- Volunteers
- 56 people
- Sponsor
- Universitas Indonesia
Acute Respiratory Failure, Mechanically Ventilated Patients
Concurrent Trigger Sensitivity Adjustment And Diaphragmatic Facilitation On Weaning From Mechanical Ventilation
As Acute respiratory failure (ARF) is a challenging serious condition especially when it necessitates intubation to deliver mechanical ventilation which is a fundamental strategy for supporting the respiratory function when the…
- Trial name
- NCT05387720
- Testing
- Manual diaphragmatic facilitation (PNF) technique, Trigger sensitivity adjustment on mechanical ventilation, concurrent trigger sensitivity adjustment and manual diaphragmatic facilitation (PNF) technique
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Sleep
Effect of Asynchronies on Sleep Disruption During Mechanical Ventilation
Mechanically ventilated (MV) patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SleepUCI (NCT05847374)
- Testing
- Polysomnography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Airway Extubation
Exploring the Use of Pulse Tissue Doppler in Predicting Extubation Success in Mechanically Ventilated Patients
Determining the appropriate extubation timing for mechanically ventilated patients is a critical issue in the Intensive Care Unit (ICU).
- Trial name
- NCT06154811
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Weaning Failure, Diaphragm Defect
Value of Diaphragm Function Predicting Weaning From Mechanical Ventilation
The reason of failure of weaning from mechanical ventilation is that their respiratory loads exceeding the capacity of their respiratory muscles.
- Trial name
- NCT05632822
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Peking Union Medical College Hospital
Alcoholism, Respiration, Artificial
Pilot Study Evaluating Stress Response and Immune Function in Mechanically Ventilated Patients With Alcohol Use Disorders Treated With Propofol or Midazolam
The aim of this study is to evaluate the effects of the sedatives propofol and midazolam on stress response and immune function in critically ill patients with alcohol use disorders who are undergoing mechanical ventilation.
- Trial name
- NCT00871039
- Testing
- Propofol, Midazolam
- Where
- 2 sites in United States
- Sponsor
- Virginia Commonwealth University
Communication, Ventilation Therapy; Complications
Testing a Novel Manual Communication System for Mechanically Ventilated ICU Patients
The objective of this study is to gather initial information about the testing of a novel manual communication system for mechanically ventilated Intensive Care Unit (ICU) subjects.
- Trial name
- NCT04105751
- Testing
- Novel Communication System
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Massachusetts, Worcester
Intensive Care (ICU) Patients
Recovery and Aftercare in Post Intensive Care Therapy Patients - RAPIT Study
In 2010 alone were admitted 33,361 patients for treatment in Danish intensive care units. There is evidence to former intensive care patients have a significant symptom burden that affect recovery, function and activity for up to…
- Trial name
- RAPIT (NCT01721239)
- Testing
- Standardized Followup program
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- Hillerod Hospital, Denmark
Obesity, Respiratory Insufficiency
Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit
Obesity is a significant health care issue in the United States, particularly among the critically ill. Preliminary research has shown that differences in ventilator management exist among obese and non-obese individuals.
- Trial name
- NCT00296088
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Ohio State University
Ventilation Acquired Pneumonia
The Effect of Continuous Management of Suction Cuff Pressure and Subglottic Irrigation Suction on Preventing VALRI Study
Assessing the effectiveness of continuous cuff pressure management combined with subglottic suction irrigation in reducing ventilator-associated lower respiratory tract infections (VALRTI) in mechanically ventilated patients at…
- Trial name
- SCOPE (NCT06867237)
- Testing
- Suction cuff pressure
- Volunteers
- 90 people
- Sponsor
- Shanghai Zhongshan Hospital
Mechanically Ventilated ICU Patients
Grip Test in Ventilated ICU Patients
ICU patients do experience extubation failure. Guidelines rarely include muscle strength criteria. Prior work indicates that grip strength is a reliable surrogate for muscle strength.
- Trial name
- griptest92 (NCT01305421)
- Testing
- grip test
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Brugmann
Pulmonary Disease, Chronic Obstructive
Timing of Dilation Tracheostomy in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is: to evaluate the optimal time-point for percutaneous dilation tracheostomy in COPD patients in terms of duration on mechanical ventilation, length of stay on ICU and mortality; to evaluate the rate of…
- Trial name
- NCT01021202
- Testing
- Percutaneous dilation tracheostomy
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ventilator Associated Pneumonia, Death
Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)
Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible.
- Trial name
- NCT01393431
- Where
- Argentina
- Volunteers
- 34 people
- Sponsor
- Universidad Nacional de Rosario
Mechanical Ventilation, Virtual Reality
Immersive Virtual Reality in Mechanically Ventilated Patients
New or worsening cognitive impairment occurs in up to 58% of survivors of critical illnesses and are long-lasting with significant disability and socioeconomic cost.
- Conditions
- Mechanical Ventilation, Virtual Reality, Delirium
- Trial name
- NCT03569358
- Testing
- Immersive Virtual Reality, EEG headband
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Critical Illness, Invasive Mechanical Ventilation
MOdifiable facTors to Improve VentilAtion ThErapy in ICU
ABSTRACT Introduction: Invasively ventilated patients in low and middle-income countries (LMICs) experience significantly higher mortality compared to those in High income countries (HICs).
- Conditions
- Critical Illness, Invasive Mechanical Ventilation, ICU Mortality, Developing Countries
- Trial name
- MOTIVATE-ICU (NCT06288724)
- Volunteers
- 625 people
- Sponsor
- Nat Intensive Care Surveillance - MORU
Effect of Protocolized Sedation on Days of Mechanical Ventilation in the ICU
Evaluation of an Analgosedation Protocol in Mechanically Ventilated Patients
The purpose of this study is to evaluate how the investigators provide sedation (medicine that make you sleepy) in the investigators intensive care unit (ICU).
- Trial name
- NCT02100735
- Testing
- Sedation protocol
- Where
- United States
- Sponsor
- Tampa General Hospital
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Brain Injury, Intracranial Pressure
Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.
- Trial name
- PrePARE (NCT00538616)
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Carmelo Graffagnino
Delayed Gastric Emptying
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention…
- Trial name
- NCT05342818
- Testing
- Neostigmine, Ondansetron 8mg, Metoclopramide Injection
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Tanta University
Respiratory Infection
Netosis in Determination of Respiratory Infection Severity
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection.
- Trial name
- NETMINDERS (NCT04318691)
- Testing
- Blood sampling, Bronchoalveolar lavage
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris