Clinical trials: Meconium Aspiration
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting
The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (>6 hours of life).
- Conditions
- Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant, Transient Tachypnea of the Newborn, Meconium Aspiration Syndrome
- Trial name
- NCT07344714
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Meconium Aspiration Syndrome, Infant, Newborn, Disease
Time of Positive Pressure Ventilation in Non-vigorous Infants Born Through Meconium-stained Amniotic Fluid
Background: Meconium stained amniotic fluid (MSAF) complicates 3 to 14% of pregnancies, causing meconium aspiration syndrome (MAS) in 5-10% of neonates born.
- Conditions
- Meconium Aspiration Syndrome, Infant, Newborn, Disease, Neonatal Resuscitation
- Trial name
- MASTIME (NCT04076189)
- Testing
- Endotracheal suctioning, No endotracheal suctioning
- Where
- 2 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University Hospital Padova
Perinatal Morbidity
Post Term Pregnancy - Induction of Labor or Monitoring of Pregnancy
Post term pregnancy is a risk pregnancy. Aim of the study was to investigate whether induction of labor at gestational age 289(41 weeks+2 days) reduces neonatal morbidity compared to expectant management.
- Trial name
- NCT00385229
- Testing
- induction of labor
- Where
- Norway
- Volunteers
- 508 people
- Sponsor
- St. Olavs Hospital
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Meconium Aspiration Syndrome
Meconium Aspiration and Tracheal Suctioning-Feasibility Study
Feasibility study to randomize non-vigorous newborn infants born through meconium-stained amniotic fluid to endotracheal suctioning or immediate resuscitation.
- Trial name
- MATS (NCT02708563)
- Testing
- Immediate intubation, Immediate resuscitation
- Sponsor
- St. Louis University
Infant, Newborn, Hypertension, Pulmonary
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
This prospective, randomized controlled trial tested whether initiating iNO therapy earlier would reduce death and reduce the use of extracorporeal membrane oxygenation (ECMO) -- temporary lung bypass -- therapy compared with the…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- Early iNO (NCT00005773)
- Testing
- Inhaled Nitric Oxide, Standard iNO therapy
- Where
- 18 sites in United States
- Volunteers
- 302 people
- Sponsor
- NICHD Neonatal Research Network