Clinical trials: Mediastinal Cancer
Lung Cancer
Thoracoscopy in Patients With Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Diagnostic procedures such as thoracoscopy may help to measure a patient's response to previous treatment. PURPOSE: Diagnostic trial to determine the accuracy of thoracoscopy in patients who have stage IIIA non-small…
- Trial name
- NCT00003566
- Testing
- videothoracoscopy
- Where
- 72 sites in United States, Puerto Rico
- Volunteers
- 75 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Large B-cell Lymphoma
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
This is a randomized, open-label study in adult patients who have completed standard first line therapy for large B-cell lymphoma (LBCL) and achieved a complete response or partial response suitable for observation, but who have…
- Trial name
- ALPHA3 (NCT06500273)
- Testing
- cemacabtagene ansegedleucel, Fludarabine, Cyclophosphamide
- Where
- 85 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Allogene Therapeutics
Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
ADMIRAL Trial: Adaptive Mediastinal Radiation With Chemo-Immunotherapy
This phase II trial studies two questions in patients with stage III NSCLC: 1) does it improve cancer control to add the drug Durvalumab, a type of immunotherapy, earlier in the treatment course; and 2) by intensifying treatment…
- Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
- Trial name
- NCT04372927
- Testing
- Cisplatin, Durvalumab, Etoposide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Washington
Lung Cancer
Personalized Sequence for Thoracic, Esophageal, and H&N Cancer
The next generation of personalized medical treatment according to the type of personal genetic information are evolving rapidly.
- Trial name
- NCT02299622
- Testing
- Genetic test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Lung Cancer (NSCLC)
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies.
- Trial name
- NCT06921681
- Testing
- Cryobiopsy of lymph nodes group 6 sec, Cryobiopsy lymphnode group 3 sec
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University of Zurich
Mediastinal Neoplasms
Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer
The purposes of this study are: To determine the overall response rate of patients treated with at least 2 cycles of this regimen. To determine the feasibility and toxicity of the combination of topotecan and docetaxel.
- Trial name
- NCT00315211
- Testing
- Intravenous Topotecan, Intravenous Docetaxel
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Aultman Health Foundation
Non-small Cell Lung Cancer
Prediction of Mediastinal Station IV Lymph Node Metastasis in Non-small Cell Lung Cancer
Mediastinal lymph node metastasis is a common metastasis pathway of non-small cell lung cancer (NSCLC), and its occurrence is closely related to the lymphatic drainage pattern, which is different in different pulmonary lobe…
- Trial name
- NCT06496360
- Testing
- Artificial Intelligence
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Qilu Hospital of Shandong University
Mediastinal Lymphadenopathy, Lung Neoplasms
Evaluation of the Utility of Rapid On-site Cytology Performed by an Interventional Pulmonologist During EBUS-TBNA.
This study is a single-centre, prospective observational analysis conducted at the Alessandria Hospital, aimed to evaluating the role of Rapid On-Site Evaluation (ROSE) performed directly by the interventional pulmonologist…
- Trial name
- ROSE (NCT07590947)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Lymphoma, B Cell, Lymphoma Non-Hodgkin
A Phase 1/2 Study of UB-VV400 With Rapamycin in Relapsed/Refractory B-cell Malignancies
This study is a Phase 1/2 dose-finding and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV400. The study will enroll patients with relapsed/refractory B-cell malignancies, including large B-cell…
- Conditions
- Lymphoma, B Cell, Lymphoma Non-Hodgkin, High Grade B Cell Lymphoma, Richter Transformation Lymphoma
- Trial name
- NCT07735533
- Testing
- UB-VV400, Rapamycin (sirolimus)
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Umoja Biopharma
Chest Wall Tumor, Breast Cancer
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease
Radiation therapy is an essential treatment for tumors in the chest area, including breast, lung, esophageal, mediastinal cancers, and spine metastases.
- Conditions
- Chest Wall Tumor, Breast Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- NCT07685938
- Testing
- Atorvastatin and Lisinopril
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center