Clinical trials: Mediastinal Cancer
Thymoma, Myasthenia Gravis
The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum
Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy.
- Conditions
- Thymoma, Myasthenia Gravis, Mediastinal Tumor
- Trial name
- NCT03613272
- Testing
- Subxiphoid approach extended thymectomy by VATS, Intercostal approach extended thymectomy by VATS
- Where
- 5 sites in China
- Volunteers
- 200 people
- Sponsor
- Jiang Fan
Lung Cancer, Mediastinal Lymphadenopathy
Capillary Versus Suction Needle Aspiration for Endobronchial Ultrasound (EBUS) Biopsies.
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration is a procedure used to obtain tissue samples (biopsies) of lymph nodes near the airways or of lung tumours growing in close proximity to the airways.
- Conditions
- Lung Cancer, Mediastinal Lymphadenopathy, Thoracic Cancer
- Trial name
- CAPSUNN-EBUS (NCT04306614)
- Testing
- Endobronchial Ultrasound guided Transbronchial Fine Needle Aspiration
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Western University, Canada
Lung Cancer, Lung Cancer Metastatic
Needlescopic-assisted Uniportal vs Uniportal VATS
The investigators' study aims is to evaluate the safety and efficacy of uniportal VATS under assistance of needlescopic instruments through additional 2-3 mm ports compared to conventional uniportal VATS in patients with lung…
- Conditions
- Lung Cancer, Lung Cancer Metastatic, Bullous Disease Lung, Nodule Solitary Pulmonary
- Trial name
- UNeed (NCT03439696)
- Testing
- Thoracoscopic surgery
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- IRB of NTUH Hsin-Chu Branch
Lung Cancer, Lymphoma
Use of EBUS TBNA for Cell Culture as an Aid to Diagnose Lung Cancer and Lymphoma
Participants who are scheduled to have an endo bronchial ultrasound (EBUS) trans bronchial needle aspiration (TBNA) will provide additional samples.
- Conditions
- Lung Cancer, Lymphoma, Non-small Cell Lung Cancer, Non-Hodgkin Lymphoma
- Trial name
- EBUS (NCT02710565)
- Testing
- Cohort
- Where
- 2 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Adult Nasal Type Extranodal NK/T-Cell Lymphoma, Adult T-Cell Leukemia/Lymphoma
Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma
This pilot clinical trial studies Salvia hispanica seed in reducing the risk of returning disease (recurrence) in patients with non-Hodgkin lymphoma.
- Conditions
- Adult Nasal Type Extranodal NK/T-Cell Lymphoma, Adult T-Cell Leukemia/Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-Cell Lymphoma
- Trial name
- NCT02652715
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Mediastinal Tumor
Totally no Tube (TNT) Uniportal Video-assisted Thoracoscopic Surgery (VATS) VS Traditional Uniportal VATS for Mediastinal Tumor
TNT surgery is a new area of exploration and evolution in thoracic minimal invasive surgery. TNT Uniportal Video-assisted Thoracoscopic Surgery (VATS) has become popular during mediastinal tumors resection.
- Trial name
- NCT03537430
- Testing
- TNT uniportal VATS mediastinal tumor resection, Traditional uniportal VATS mediastinal tumor resection
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Xueying Yang
Diffuse Large B Cell Lymphoma, Primary Mediastinal (Thymic) Large B-cell Lymphoma
Study of Ibrutinib in Combination With Bendamustine and Rituximab for Patients With Relapsed/Refractory Aggressive BCL
This is a phase 2 study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (ibrutinib), in combination with bendamustine and rituximab (BR) in subjects with previously treated aggressive B cell non Hodgkin lymphoma (aB-NHL)…
- Conditions
- Diffuse Large B Cell Lymphoma, Primary Mediastinal (Thymic) Large B-cell Lymphoma, Transformed Indolent Lymphoma, Recurrent Disease
- Trial name
- NCT02747732
- Testing
- Bendamustine 90 mg/m2 IV on Days 1-2, Cycles 1-6
- Where
- 2 sites in Israel
- Volunteers
- 72 people
- Sponsor
- Meirav Kedmi MD
Breast Cancer, Lung Cancer
Cardiotoxicity of Radiation Therapy (CTRT)
The overall objective of this proposal is to determine the utility of sensitive imaging and biomarker measures in detecting subclinical cardiotoxicity across a spectrum of radiation doses to the heart.
- Conditions
- Breast Cancer, Lung Cancer, Mediastinal Lymphomas
- Trial name
- NCT02769299
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Mediastinal Neoplasms
Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer
The purposes of this study are: To determine the overall response rate of patients treated with at least 2 cycles of this regimen. To determine the feasibility and toxicity of the combination of topotecan and docetaxel.
- Trial name
- NCT00315211
- Testing
- Intravenous Topotecan, Intravenous Docetaxel
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Aultman Health Foundation
Neoplasm of Mediastinal Lymph Nodes
Predicting Malignancy Using Endoluminal Ultrasound Characteristics in Mediastinal Lymph Nodes
There is no single method to investigate mediastinal LN invasion. Hence, a patient may have to undergo several tests and procedures. Noninvasive and invasive approaches are employed.
- Trial name
- CT0024 (NCT01329575)
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma
Optical Biopsy for Thoracic Lymph Nodes.
EUS-FNA is the recommended diagnostic examination of choice when patients present with suspected lower mediastinal lymph nodes on imaging.
- Conditions
- Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma, Sarcoidosis
- Trial name
- NCT02689050
- Testing
- Needle based confocal laser endomicroscopy (nCLE)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mediastinal Tumor
Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis
- Trial name
- NCT03214341
- Testing
- MRI diffusion
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Benign and Malignant Mediastinal and Hilar Lymph Nodes Known or Suspected Malignancy
Procedural Outcomes in Endobronchial Ultrasound - Transbronchial Needle Aspiration (EBUS-TBNA) With and Without Rapid On-Site Evaluation (ROSE)
The objective of this study is comparing the attributable procedural time of Endobronchial Ultrasound - Transbronchial Needle Aspiration (EBUS-TBNA) when sampling mediastinal and hilar lymph nodes with or without Rapid On-Site…
- Trial name
- ROSE (NCT02028052)
- Testing
- ROSE, 22 gauge Vizishot needles
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Duke University
Lung Cancer With Mediastinal Lymph Node Involvement
Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging
A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by…
- Trial name
- NCT01653002
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Mediastinal Lymphadenopathy, Hilar Lymphadenopathy
EBUS-TBNA Versus EBUS-TBNB
A prospective diagnostic clinical study randomising patients undergoing endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) of enlarged mediastinal and hilar lymph nodes to have sampling using the usual…
- Conditions
- Mediastinal Lymphadenopathy, Hilar Lymphadenopathy, Carcinoma, Lymphoma
- Trial name
- NCT01467635
- Testing
- Endobronchial ultrasound guided lymph node sampling
- Where
- 3 sites in Germany, United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Mediastinal Lymphadenopathy, Hilar Lymphadenopathy
Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies
The main purpose of the present study is to assess whether the sensitivity of Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) is superior to that of conventional TBNA in the diagnosis of hilar/mediastinal…
- Conditions
- Mediastinal Lymphadenopathy, Hilar Lymphadenopathy, Lymphoma, Lung Neoplasms
- Trial name
- NCT01658280
- Testing
- EBUS-TBNA
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Thymoma, Thymic Carcinoma
Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage
Background: Cisplatin-containing chemotherapy is the standard treatment for advanced tumors of the thymus that cannot be removed surgically.
- Trial name
- NCT00589290
- Testing
- Belinostat (PDX101)
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Mediastinal Tumors
Echocardiographic Evaluation of the Change on Pulmonary Blood Flow and Cardiac Function Induced by Capnothorax During One Lung Ventilation
Video-assisted thoracoscopic extended thymectomy (VATET) is a minimally-invasive method for excision of mediastinal mass instead of open thymectomy.
- Trial name
- NCT02220231
- Testing
- capnothorax
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Non Small Cell Lung Cancer (NSCLC), Indication Mediastinal Staging
Single Scope Staging of Lung Cancer With Endosonography
Rationale: Lung cancer is the most commonly diagnosed cancer worldwide and is the most frequent cause of cancer death. Accurate staging is important because it directs treatment and prognosis.
- Conditions
- Non Small Cell Lung Cancer (NSCLC), Indication Mediastinal Staging, Complete Endosonography
- Trial name
- SCORE (NCT02014324)
- Testing
- Endosonography
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 215 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mediastinal Tumours and Lymph Nodes, Celiac, Perigastric and Peri-pancreatic Lymph Nodes
Controlled Trial Comparing the Performance of 22 Gauge Versus 25 Gauge EUS-FNA Needles (FNA-22G-25G)
The aim of the study is to compare the performance characteristics of EUS-FNA 22 Gauge needle and EUS FNA 25 Gauge needle in terms of cellularity and diagnostic yield for diagnosis of various pathologies, including lymph nodes…
- Conditions
- Mediastinal Tumours and Lymph Nodes, Celiac, Perigastric and Peri-pancreatic Lymph Nodes, Pancreatic Masses, Liver Masses
- Trial name
- NCT01016288
- Where
- 9 sites in Denmark, Germany and 1 more
- Volunteers
- 135 people
- Sponsor
- University Hospital, Gentofte, Copenhagen