Clinical trials: Medical Treatment
Pelvic Floor Disorders
Treatment of Scars and Dysfunctions of the Pelvic Floor in Postpartum
Recruitment of patients who have suffered third- and fourth-degree perineal tear during childbirth, and who have given birth at the Hospital Universitario Marqués de Valdecilla (Santander, Spain).
- Trial name
- NoRFor (NCT04098965)
- Testing
- Pysiotherapy techniques, physician treatment
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad de León
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Constipation, Constipation; Neurogenic
MOWOOT Device to Treat Constipation in Adults
The aim was to assess the safety and effectiveness of the automatic colon-specific massage with the MOWOOT device for patients suffering from chronic constipation due to Multiple Sclerosis, Parkinson Disease (NBD) or other…
- Conditions
- Constipation, Constipation; Neurogenic, Constipation Chronic Idiopathic
- Trial name
- NCT04262752
- Testing
- intermittent colonic exo-peristaltic massage treatment with the MOWOOT medical device
- Where
- 3 sites in Spain, United Kingdom
- Volunteers
- 100 people
- Sponsor
- usMIMA S.L.
Medical Education
Online Primary Care Physician (PCP) Training in Screening, Brief Intervention, Referral, and Treatment
This project seeks to develop a comprehensive, computer-based education program for primary care physicians that will improve their skills in structured substance abuse screening, brief interventions, and referral and treatment…
- Trial name
- NCT01326936
- Testing
- Online education
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical Directions, Inc
Primary Open Angle Glaucoma, Ocular Hypertension
Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension
This is a randomized study with two treatment arms: 'initial Selective Laser Trabeculoplasty (SLT) followed by conventional medical therapy as required' ('Laser-1st') and 'medical therapy without laser ('Medicine-1st').
- Trial name
- LIGHT (NCT03395535)
- Testing
- Primary Selective Laser Trabeculoplasty Treatment Pathway, Primary Medical Treatment Pathway
- Where
- United Kingdom
- Volunteers
- 718 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Parkinson's Disease
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
The goal of the second phase of the study is to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's…
- Trial name
- NCT01076452
- Testing
- Bilateral Deep Brain Stimulation
- Where
- 14 sites in United States
- Volunteers
- 299 people
- Sponsor
- US Department of Veterans Affairs
Cell Transplantation
An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation
Chronic obstructive pulmonary disease(COPD)is characterized by recurrent cough, expectoration and asthma, and eventually develop chronic pulmonary heart disease ,chronic respiratory failure and even death.
- Trial name
- NCT03021681
- Testing
- autologous bronchial basal cell transplantation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Huai'an No.1 People's Hospital
Crohn's Disease
Efficacy of CROWN in Repair and Maintenance of the Intestinal Mucosa in Patients With CD Receiving Anti-TNF Therapy
The purpose of this study is to evaluate CROWN's efficacy in supporting the repair and maintenance of the intestinal mucosa of patients with moderately to severely active Crohn's Disease receiving anti-Tumor Necrosis Factor (TNF)…
- Trial name
- PIONEER-CD (NCT02793778)
- Testing
- CROWN
- Where
- 39 sites in United States
- Volunteers
- 42 people
- Sponsor
- Prometheus Laboratories
Availability of the Different Types of Anesthesia Neuromuscular Monitoring Devices Throughout European Hospitals, Health Care Utilization
European Neuromuscular Monitoring Survey
This survey aims to better define the availability of the different types of anesthesia neuromuscular monitoring devices throughout European hospitals.
- Conditions
- Availability of the Different Types of Anesthesia Neuromuscular Monitoring Devices Throughout European Hospitals, Health Care Utilization, Medical Device Availability, Medical Staff Availability
- Trial name
- NCT04517578
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 692 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Asthma
An Observational, Retrospective Multicentre Medical Record Review to Describe the Post-authorisation Early Clinical Experience of Dupilumab in the Treatment of Adult Severe Asthma
The purpose of this retrospective medical record review is to describe the real-world clinical effectiveness of dupilumab with patients in the United Kingdom with severe asthma.
- Trial name
- DUPIAZA (NCT06064526)
- Testing
- No intervention
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Sanofi
Multiple Myeloma
Denosumab for High Risk SMM and SLiM CRAB Positive, Early Myeloma Patients
This is a randomized, 2-arm phase II, placebo-controlled, multi-center study, where the investigators aim to evaluate whether the reported benefits of denosumab, delay of SRE and decrease in myeloma growth promotion, reduce the…
- Trial name
- DEFENCE (NCT03792763)
- Testing
- Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA]
- Where
- 10 sites in Austria, Germany and 1 more
- Volunteers
- 8 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Heart Failure With Reduced Ejection Fraction
Digital Solutions in Heart Therapy (DIGNITY)
This study aims to assess the safety and effectiveness of telemedicine guided strategy on guideline-directed medical therapy (GDMT) optimization in hospitalized patients with heart failure in comparison to usual care in…
- Trial name
- DIGNITY - HF (NCT06942221)
- Testing
- usual care, guideline-directed medical therapy
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Stone Lower Ureter
L-Arginine Role for Stone Lower Ureter : A Randomized Control Study
To evaluate the effects of L-Arginine 1000mg once daily as a medical expulsive therapy (MET) for lower ureter stones.
- Trial name
- NCT06753526
- Testing
- NSAID, L-Arginine, 500 Mg Oral Capsule, Tamsulosin 0.4 mg QD
- Where
- Egypt
- Volunteers
- 153 people
- Sponsor
- Sohag University
Heart Failure With Reduced Ejection Fraction
Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT
SEMI trial is a single-center, real-world based prospective cohort study. The study enrolled acute heart failure patients admitting to the hospital and intended to accept heart failure therapy.
- Trial name
- SEMI (NCT05799638)
- Testing
- Guideline-Directed Medication Treatment (GDMT)
- Where
- China
- Volunteers
- 263 people
- Sponsor
- Chongqing Medical University
Bacterial Infections, Acute Bacterial Skin and Skin Structure Infection
Development of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
The purpose of this study is to assess the effect of a new critical pathway (use of guideline-based patient identification criteria and for those who meet these criteria, use of dalbavancin) compared to usual care for the…
- Trial name
- NCT03233438
- Testing
- Dalbavancin, Usual Care
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Allergan
Respiratory Distress Syndrome in Premature Infant
Immediate Treatment Outcomes of b-CPAP vs Oxygen Therapy in Preterm Babies Presenting With RDS at KCMC
Bubble - Continuous positive airway pressure (CPAP) has been reported to be effective, cheaper, simpler and more accessible compared to mechanical ventilator and surfactant treatment for preterms with respiratory distress…
- Trial name
- NCT03620448
- Testing
- bCPAP Arm, Oxygen Arm
- Volunteers
- 48 people
- Sponsor
- Kilimanjaro Christian Medical Centre, Tanzania
Osteoarthritis
Conjoint Analysis of Treatment Preferences for Osteoarthritis
The purpose of this study is to develop a conjoint analysis-based questionnaire and decision aid for patients with osteoarthritis of the knee and to compare the responses of two groups of subjects, one receiving only printed…
- Trial name
- NCT01003925
- Testing
- Standard of care for osteoarthritis treatment, Conjoint Analysis for Osteoarthritis
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- Baylor College of Medicine
Injuries, Spinal Cord, Neurogenic Bowel
Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI)
This study will look at the use of a telehealth version of a self management program in individuals with both new onset and chronic traumatic spinal cord injuries. The program is called Health Mechanics.
- Conditions
- Injuries, Spinal Cord, Neurogenic Bowel, Urinary Bladder, Neurogenic
- Trial name
- NCT01920243
- Testing
- Health Mechanics Program
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Michigan
Moderate Aortic Stenosis
Comparison of Myval THV Series With Guideline-Directed Medical Therapy in Participants With Moderate Aortic Stenosis
The primary objective of this trial is to evaluate the safety and effectiveness of Meril's Myval THV series in comparison to Guideline-Directed Medical Therapy in participants with moderate aortic stenosis.
- Trial name
- NCT07532317
- Testing
- Transcatheter aortic valve Implantation
- Volunteers
- 778 people
- Sponsor
- Meril Life Sciences Pvt. Ltd.
End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis
EXtension of Tablo TrEatmeNt Duration Registry
Observational, retrospective and prospective, multicenter, post-market study of the Tablo Hemodialysis System in hospitalized participants with End-Stage Kidney Disease or Acute Kidney Injury who are prescribed renal replacement…
- Conditions
- End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis, Acute Kidney Injury
- Trial name
- XTEND (NCT04912050)
- Testing
- Tablo Hemodialysis System
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Outset Medical