Clinical trials: Medically Unexplained Symptoms
Somatic Symptom Disorder
Alexithymia and Attachment Style in Patients With Somatic Symptoms
To evaluate whether emotional awareness, attachment style and the ability to abstract and symbolize (IQ) influence the appearance of somatic symptoms.
- Trial name
- NCT05666921
- Testing
- psychological assessment
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Meyer Children's Hospital IRCCS
Somatic Symptom Disorder (DSM-V)
Cognitive-Behavioral Therapy Enriched With Emotion Regulation Training for Multiple Somatoform Symptoms
The purpose of this study is to evaluate whether cognitive-behavioral therapy enriched with strategies from emotion regulation training leads to better improvement in somatic symptoms and comorbid problems than…
- Trial name
- ENCERT (NCT01908855)
- Testing
- Cognitive-behavioral therapy + emotion regulation training for patients with multiple somatoform symptoms, Cognitive-behavioral therapy for patients with multiple somatoform symptoms
- Where
- 7 sites in Germany
- Volunteers
- 255 people
- Sponsor
- Philipps University Marburg
Somatic Symptom Disorder
Internet-based Emotional Awareness and Expression Therapy for Somatic Symptom Disorder
The main purpose of the study is to conduct an initial feasibility evaluation of the new Internet-based EAET treatment manual. We will include 50 patients with somatic symptom disorder to take part of the treatment for nine weeks…
- Trial name
- MBS1 (NCT04122846)
- Testing
- Emotional Awareness and Expression Therapy
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Constipation - Functional, Refractory Constipation
Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients.
- Conditions
- Constipation - Functional, Refractory Constipation, Fluoxetine, fMRI
- Trial name
- NCT06221722
- Testing
- BOLD-fMRI, Regular treatment of functional constipation, fluoxetine
- Where
- 3 sites in China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Irritable Bowel, Fibromyalgia
Psychiatric Disorders and Functional Somatic Disorders
The objectives of this study are: Firstly, to investigate the association between psychiatric disorders and functional somatic disorder (FSD).
- Conditions
- Irritable Bowel, Fibromyalgia, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT06006715
- Volunteers
- 7,493 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Somatic Symptom Disorder
Use Repetitive Transcranial Magnetic Stimulation to Treat Somatic Symptom Disorder
This is a randomized double-blind sham-controlled crossover study; the interventions are high-frequency rTMS stimulation on left DLPFC and sham control. The study population is the patient with somatic symptom disorder.
- Trial name
- NCT05161819
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Superior Mesenteric Artery Syndrome, Somatic Symptom Disorder (DSM-5)
Fluoxetine in Refractory Superior Mesenteric Artery Syndrome by Targeting Comorbid Somatic Symptom Disorder
The goal of this interventional study is to evaluate whether fluoxetine, a selective serotonin reuptake inhibitor (SSRI), can alleviate core symptoms and reduce the need for surgical intervention in patients with refractory…
- Trial name
- NCT07115472
- Testing
- Fluoxetine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Health Anxiety, Hypochondriasis
Effectiveness of ICBT for Severe Health Anxiety in Clinical Psychiatry.
The aim of this study is to evaluate the clinical effectiveness of internet-based cognitive therapy for severe health anxiety within regular psychiatric care.
- Conditions
- Health Anxiety, Hypochondriasis, Illness Anxiety Disorder, Somatic Symptom Disorder
- Trial name
- NCT04921280
- Testing
- Internet based Cognitive Behavioural Therapy
- Where
- Sweden
- Volunteers
- 456 people
- Sponsor
- Karolinska Institutet
Somatic Symptom Disorder, Anxiety
Treatment of SSD With tcVNS and taVNS
This study aims to compare two non-invasive nerve stimulation devices, gammaCore and Nurosym, to find out which one is more effective in reducing physical discomfort and health-related anxiety in patients with Somatic Symptom…
- Conditions
- Somatic Symptom Disorder, Anxiety, Depression, Transcutaneous Vagus Nerve Stimulation
- Trial name
- NCT07198542
- Testing
- gammaCore Sapphire, Nurosym
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Persistent Physical Symptoms (PPS)
CBT Plus SMC Compared to SMC for Persistent Physical Symptoms in Secondary Care (PRINCE)
Brief Summary: Persistent Physical Symptoms (PPS), also known as medically unexplained symptoms (MUS) is a term used to describe a range of persistent bodily symptoms for which the exact cause is unclear.
- Trial name
- PRINCE (NCT02426788)
- Testing
- Cognitive behavioural therapy (CBT)
- Where
- 7 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- King's College London
Irritable Bowel Syndrome, Fibromyalgia
Psychological Risk Factors for Functional Somatic Disorders
The objective of this study is to explore the role of neuroticism, perceived stress, and adverse life events, respectively, in the development and perpetuation of functional somatic disorders.
- Conditions
- Irritable Bowel Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Somatoform Disorders
- Trial name
- NCT05631860
- Volunteers
- 7,493 people
- Sponsor
- University of Aarhus
Functional Somatic Disorder, Somatic Symptom Disorder
Does the First Interview Matter: A Comparing Life Stress Interview Versus a Standard Psychiatric Intake Interview for Patients With Functional Somatic Disorder
Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care.
- Trial name
- NCT06149182
- Testing
- Life stress interview according to EAET, Psychiatric interview according to "region stockholm - basutredning"
- Where
- Sweden
- Volunteers
- 189 people
- Sponsor
- Daniel Maroti
Medically Unexplained Symptoms
Impact of Humor Prescription on the Emotional Well-being of Patients With Medically Unexplained Symptoms: A Quasi-experimental Study
This study aims to study the effectiveness of the intervention for medically unexplained symptoms(MUS) in terms of changes in emotional well-being before and after the intervention (humor therapy)
- Trial name
- NCT07007013
- Testing
- Humor therapy
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Myocardial Bridge, Somatic Symptom Disorder
Somatic Symptom Disorders in Patients With Myocardial Bridge
The purpose of this study was to investigate the prevalence of physical and mental disorder in the population of patients with myocardial bridge and to describe the relationship between clinical features and the occurrence of…
- Trial name
- NCT04664387
- Testing
- coronary angiography
- Where
- China
- Volunteers
- 1,357 people
- Sponsor
- RenJi Hospital
Illness Anxiety Disorder, Somatic Symptom Disorder
Feasibility Evaluation of a Self-guided Exposure-based Digital Intervention for Health Anxiety
This study investigates the feasibility and preliminary efficacy of a self-guided, exposure-based intervention for individuals who suffer from severe health anxiety.
- Trial name
- NCT05446766
- Testing
- Self-guided Exposure-based Digital Intervention for Health Anxiety
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
Medically Unexplained Symptoms, Sense of Coherence
Sense of Coherence and Empowerment at Patients With MUPS
This is a study on Metacognitive therapy in general practice in Norway. The intervention is a small pilot study to examine whether Metacognitive therapy is feasible in an ordinary general practice.
- Trial name
- NCT05121922
- Testing
- Metacognitive Therapy
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Fibromyalgia, Irritable Bowel Syndrome
Welfare Benefits in Functional Somatic Disorders
The objective of this observational study is to estimate the number of weeks of welfare benefits, i.e. sickness benefit, unemployment benefit and social assistance, for individuals with functional somatic disorders and compare…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT05611606
- Volunteers
- 9,656 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Somatisation Disorder, Somatoform Disorders
Acceptance and Commitment Therapy for Patients With Multi-organ Bodily Distress Syndrome (Stress-4)
The aim of this study is to test the effect of Acceptance and Commitment Therapy (ACT) in patients with long lasting health problems with no known medical explanation, defined as multi-organ Bodily distress syndrome (BDS).
- Trial name
- Stress-4 (NCT01518647)
- Testing
- Acceptance and Commitment Therapy
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- University of Aarhus
Somatoform Disorders
Cognitive Behavior Therapy for Somatization Disorder
This study will examine the long-term effects of cognitive behavioral therapy on the physical symptoms, functioning, and health care utilization of people with multiple medically unexplained physical symptoms.
- Trial name
- NCT00276887
- Testing
- Cognitive Behavior Therapy, Psychiatric Consultation Letter
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Irritable Bowel Syndrome
The Effect of Shigyakusan Used for IBS and MUPS Diagnosed by Abdominal N Line Tenderness
Abstract Background \& Aims: Abdominal N line tenderness for diagnosis and shigyakusan for treatment of irritable bowel syndrome ( IBS ) and medically unexplained physical symptoms ( MUPS ) were studied.
- Trial name
- NCT02653937
- Testing
- Tsumura's shigyakusan
- Volunteers
- 1 people
- Sponsor
- Nakatani Clinic