Clinical trials: Medically Unexplained Symptoms
Somatic Symptom Disorder (DSM-5)
CBT Enriched With Emotion Regulation Training for Multiple Somatoform Symptoms (ENCERT) - A 3-year Follow-up
The purpose of this study is to evaluate whether 3 years after the end of therapy cognitive-behavioral therapy complemented with strategies from emotion regulation training leads to better improvement in somatic symptoms and…
- Trial name
- ENCERT-3YFU (NCT03982524)
- Testing
- Cognitive-behavioral therapy + emotion regulation training for patients with multiple somatoform symptoms, Cognitive-behavioral therapy for patients with multiple somatoform symptoms
- Where
- Germany
- Volunteers
- 255 people
- Sponsor
- Philipps University Marburg
Somatoform Disorders
Stress and Health Interview for Primary Care Patients With Medically Unexplained Symptoms
The goal of this study is to test the feasibility and acceptability of providing an experiential assessment interview that targets emotional and stressful experiences in primary care.
- Trial name
- NCT02151500
- Testing
- Stress and Health Interview
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Wayne State University
Fibromyalgia, Irritable Bowel Syndrome
Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective Cohort Study
This cohort study implements patient reported outcome measures (PROMs) for patients with bodily stress syndrome in a clinic for functional disorders.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Somatic Symptom, Chronic Fatigue Syndrome
- Trial name
- SYMPA (NCT04667611)
- Testing
- Psychosocial interventions
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Somatic Symptom Disorder, Persistent Physical Symptoms
ISTDP for Patients With Treatment Resistance PPS
Intensive Short-Term Psychodynamic Psychotherapy (ISTDP) for Treatment-Resistant Persistent Physical Symptoms is a therapeutic approach designed to help patients whose physical symptoms have not responded to traditional medical…
- Conditions
- Somatic Symptom Disorder, Persistent Physical Symptoms, Functional Somatic Syndrome, Functional Somatic Disorder
- Trial name
- NCT06682104
- Testing
- Individual intensive short term psychodynamic therapy
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Daniel Maroti
Musculoskeletal Diseases or Conditions, Musculoskeletal Pain
Stress and Musculoskeletal Health in Employees
This study aims to evaluate potential correlation of stress as estimated by certain biological markers, namely saliva cortisol, Heart rate variability (HRV), Electromyography (EMG) with musculoskeletal system health status, and…
- Conditions
- Musculoskeletal Diseases or Conditions, Musculoskeletal Pain, Musculoskeletal Health, Stress
- Trial name
- MUStress (NCT06488547)
- Testing
- Diaphragmatic breathing (DF), Progressive Muscle Relaxation (PMR)
- Where
- 2 sites in Greece
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Anxiety Disorders, Depression
Study Evaluating Venlafaxine Extended-Release in Depressed and Anxious Patients
To examine the efficacy and safety of venlafaxine XR in the treatment of physical and emotional symptoms in patients with an operationally-defined diagnosis of multisomatoform disorder (MSD).
- Trial name
- NCT00546923
- Testing
- Venlafaxine XR
- Volunteers
- 210 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Fibromyalgia, Irritable Bowel Syndrome
A Computer-Based Intervention for Medically Unexplained Physical Symptoms
In this study 60 people with medically unexplained physical symptoms (MUPS) will receive either a 6-session resilience skill building intervention provided fully online or a weekly computerized journaling assignment.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome
- Trial name
- NCT00468013
- Testing
- Resilience Building Exercises, Journaling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Somatic Symptom
Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression
The purpose of this study is to evaluate efficacy and safety of toludesvenlafaxine hydrochloride sustained-release tablets in the treatment of somatic symptoms in depression, to provide evidence-based basis for clinical rational…
- Trial name
- NCT05849272
- Testing
- toludesvenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Mental Health Center
Somatization Disorder
Treatment of Patients With Longstanding Unexplained Health Complaints
The purpose of this study is to determine the effect of specialized treatment (including cognitive therapy, social counselling and a recommendation letter to the patients' primary care physician) on the functional level…
- Trial name
- NCT00132197
- Testing
- Cognitive Behavioral Therapy, Recommendation of care (letter to general practitioner [GP])
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Somatic Symptom Disorder
Reappraisal Of Medical Assurance (ROMA): An Experimental Study in Patients With Functional Somatic Symptoms
Research has shown that patients with functional somatic symptoms continue to worry about having a serious disease despite medical reassurance from their doctors.
- Trial name
- ROMA (NCT04044469)
- Testing
- Immunization-enhancement, Immunization-inhibition, Control group
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Philipps University Marburg
Somatoform Disorders, Somatic Symptom Disorder
Build a Research Clinic for Somatoform Patients
To investigate the effects of the two following interventions on somatoform patients:1. case management model2. psychotherapy, based on cognitive-behavioral therapy and biofeedback therapy
- Trial name
- NCT04835103
- Testing
- CM, P/T
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- National Taiwan University Hospital
Psychological Distress, Insomnia
A Multicenter Cross-sectional Study on Mental Health of Patients With Multiple Myeloma
Multiple myeloma patients with normal ability of communication and understanding will be enrolled. DT, GAD-7, PHQ-15 and PSQI scales are designed to assess the mental health status of the patients.
- Conditions
- Psychological Distress, Insomnia, Somatic Symptoms
- Trial name
- NCT05620420
- Where
- China
- Volunteers
- 501 people
- Sponsor
- RenJi Hospital
Somatization Disorder
Assessment of Somatic Symptom in Chinese Community-Dwelling People
With the rapid aging and worsening psychological problems worldwide, the special focus on somatic symptom and other psychological diseases of the older population is needed.
- Trial name
- NCT04815863
- Testing
- Assessment of somatic symptom disorder with SSS-CN, Assessment of depressive symptoms disorder with PHQ-9, Assessment of anxiety disorder with GAD-7
- Where
- 2 sites in China
- Volunteers
- 9,110 people
- Sponsor
- RenJi Hospital
Functional Somatic Disorder, Somatic Symptom Disorder
Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist Support
Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care.
- Conditions
- Functional Somatic Disorder, Somatic Symptom Disorder, Functional Somatic Syndromes
- Trial name
- NCT06301360
- Testing
- Internet based Emotional Awareness and Expression Therapy (I-EAET)
- Where
- 2 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Daniel Maroti
Post COVID-19 Condition (PCC)
Basel Long COVID-19 Cohort Study and Digital Long COVID Substudy
The Basel Long COVID Cohort Study (BALCoS) is a registry-based cohort study that focuses on the patients' present health status, symptoms, the course of these symptoms, and potential mechanisms involved.
- Trial name
- BALCoS/DiLCoS (NCT05781893)
- Testing
- Digital intervention (DiLCoS), Data collection
- Where
- Switzerland
- Volunteers
- 196 people
- Sponsor
- University Hospital, Basel, Switzerland
Long COVID, Chronic Fatigue Syndrome
tVNS in Long COVID-19
A prior open label study has shown that transcutaneous vagus nerve stimulation [tVNS] can improve the health of some patients with postacute sequelae of SARS-CoV-2 infection (PASC), severely affected enough to also fulfill…
- Trial name
- NCT06585254
- Testing
- Transcutaneous vagus nerve stimulator
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychological Flexibility, Somatic Symptom
Acceptance and Commitment Therapy Based Group Psychoeducation for Nursing Students
In this study, the effects of acceptance and commitment therapy-based group psychoeducation applied to nursing students on psychological flexibility and somatic symptoms will be examined.
- Trial name
- NCT06553703
- Testing
- Acceptance and commitment therapy based group psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Tugba Yildirim
Psychiatric Disorder, Somatic Symptom
National Investigation in College and High School Among Adolescents on Health and Substances at the FSEF
For the clinical component: Describe the young people hospitalised in residential care at the FSEF, in particular through vulnerability factors and their psychosocial repercussions (school level, repetition, intensity of…
- Conditions
- Psychiatric Disorder, Somatic Symptom, Traumatic Injury
- Trial name
- EnCLASS-FSEF (NCT05225441)
- Where
- France
- Volunteers
- 598 people
- Sponsor
- Fondation Santé des Étudiants de France
Adult Women
Interoceptive Awareness and Dream Themes
Individual differences in reported dream themes may reflect not only waking emotional and cognitive experiences but also characteristic ways of attending to, interpreting, and regulating bodily signals.
- Trial name
- NCT07716514
- Where
- Turkey (Türkiye)
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Somatic Symptom and Related Disorders, Somatic Symptom Disorder
Telehealth Group-based Emotional Awareness and Expression Therapy for Patients With Persistent Physical Symptoms: A Pilot Study
Delivering Emotional Awareness and Expression Therapy (EAET) through digital or telehealth platforms in a group format offers several key advantages.
- Conditions
- Somatic Symptom and Related Disorders, Somatic Symptom Disorder, Functional Somatic Disorder, Functional Somatic Syndrome
- Trial name
- NCT06631963
- Testing
- Emotional Awareness and Expression Therapy
- Where
- Sweden
- Sponsor
- Daniel Maroti