Clinical trials: Medically Unexplained Syndrome
Functional Neurological Disorders
The Pathophysiology of Functional Neurological Disorders
Functional disorders, also called psychogenic or psychosomatic are very common, disabling and their costs to society are immense.
- Trial name
- NCT02905877
- Testing
- Behavioural study
- Where
- United Kingdom
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University College, London
Functional Neurological Disorder, Functional Movement Disorder
The Effect of Psychoeducational Diagnosis Communication on Perception of Illness, Satisfaction, and Behavioral Intentions Among Patients With Functional Neurological Movement Disorders
Functional neurological movement disorders are common conditions that can lead to significant limitations in daily life. They result from a functional disorder in the brain.
- Trial name
- NCT07588282
- Testing
- Psychoeducational communication guide for first-diagnosis of FND
- Where
- Austria
- Volunteers
- 35 people
- Sponsor
- Medical University of Graz
Conversion Disorder
TMS and Attentional Bias in Functional Motor Disorder
Functional motor disorders, also called motor conversion disorder, are common reasons for attendance at neurology outpatient clinics.
- Trial name
- NCT02102906
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Psychogenic Nonepileptic Seizures, Dissociative Seizures
ADIE-FS - Aligning Dimensions of Interoceptive Experience in Patients With Functional Seizures
Functional seizures are common and harmful. They look like epileptic seizures but are not caused by the excess electrical discharges in the brain that arise in epilepsy.
- Conditions
- Psychogenic Nonepileptic Seizures, Dissociative Seizures, Psychogenic Pseudoseizure, Functional Neurological Disorder
- Trial name
- ADIE-FS (NCT06105996)
- Testing
- Interoceptive training
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Anxiety, Somatoform Disorders
Evaluating the Cost Effectiveness of ISTDP: A Quasi Experimental Study
Objective: To evaluate whether or not cases treated with Intensive Short-term Dynamic Psychotherapy (ISTDP) facilitate healthcare cost reduction, whether any observed reduction is greater than that of a control group and whether…
- Conditions
- Anxiety, Somatoform Disorders, Personality Disorders, Depression
- Trial name
- CEISTDP (NCT01924715)
- Testing
- ISTDP
- Where
- Canada
- Volunteers
- 1,082 people
- Sponsor
- Nova Scotia Health Authority
Major Depression, Minor Depression
Neuropattern - Assessment of a Translational Diagnostic Tool for Depression, Adjustment- and Somatoform-disorders
Neuropattern is a first translational tool in stress medicine. Neuropattern is a diagnostic tool, which can be applied by in- and outpatients and physicians to detect dysregulation in the stress response network.
- Conditions
- Major Depression, Minor Depression, Somatoform Disorders, Adjustment Disorders
- Trial name
- Neuropattern (NCT01062880)
- Testing
- self-guided internet modules
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Trier
Somatoform Vertigo/Dizziness
Tailored Care for Somatoform Vertigo/Dizziness
The purpose of this study is to evaluate the efficacy of a manualised, multimodal group psychotherapy, based on integrative psychotherapy (IPT) and tailored to somatoform vertigo/dizziness (SVD) subgroups of mental disorders…
- Trial name
- NCT02320851
- Testing
- SVD-tailored Integrative Psychotherapy (IPT), Self-help group (SHG)
- Volunteers
- 216 people
- Sponsor
- Technical University of Munich
Pain Syndrome, Pain
A Pilot Study Assessing the Effectiveness of Use of Guided Imagery for Treatment of Pain and Symptom Management in Women With Post-mastectomy Pain Syndrome
To learn if using guided imagery and deep breathing techniques can help with pain management in patients who have post-mastectomy pain syndrome.
- Conditions
- Pain Syndrome, Pain, Symptom Management
- Trial name
- NCT05408741
- Testing
- The Intervention Group, The Control Group
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Somatoform Disorders
Treatment of Medically Unexplained Physical Ailments (Somatization Disorder)
The purpose of this study is to compare cognitive behavior therapy (CBT) to medical care-as-usual for the treatment of patients with high levels of medically unexplained physical symptoms (Somatization Disorder).
- Trial name
- NCT00050583
- Testing
- Cognitive Behavioral Therapy, CBT
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Chronic Pain
Observational Study of Ketamine Infusions for the Treatment of Chronic Pain
This observational study will collect prospectively specified data on patient characteristics and clinically relevant outcomes in patients who receive a ketamine infusion at Stanford Pain Management Center for the treatment of…
- Trial name
- NCT05477004
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Theresa Lii
Multiple Sclerosis, Functional Neurological Disorders
Bridging Gaps in the Multidimensional Assessment and Management of Overlapping Symptoms in Multiple Sclerosis and Functional Motor Disorders: Prevalence and Rehabilitation Effectiveness
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system that may cause a broad range of motor and non-motor symptoms.
- Trial name
- NCT07856485
- Testing
- Functional Motor Disorder-Specific Multidisciplinary Rehabilitation, Conventional Multiple Sclerosis Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 192 people
- Sponsor
- IRCCS San Raffaele
Conversion Disorder
Cytokine Levels in Conversion Disorder
The aim of this study is whether the proinflammatory cytokine levels in patients with conversion disorder is increased or not changed in the acute phase and subacute - chronic periode, compared with controls.
- Trial name
- NCT00971360
- Testing
- conversion disorder
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Trakya University
Functional Neurological Disorder
Behavioural and Electrophysiological Effects of rTMS in Functional Neurological Disorders
The purpose of this study is to better understand Functional Neurological Disorders (FND) by measuring movement timing and brain activity in patients with FND during deliberate movements and when expressing an 'intention' to…
- Trial name
- NCT04942600
- Testing
- MagStim Rapid2 Transcranial Magnetic Simulation
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- University of Manitoba
Body Dysmorphic Disorders
Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder
In this pilot study 12 adult outpatients with body dysmorphic disorder that has not responded to at least one adequate trial of a serotonin reuptake inhibitor will be treated openly with a single oral dose of psilocybin.
- Trial name
- NCT04656301
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Body Image Disturbance, Eating Disorder Symptom
Evaluating Body Acceptance Programs for Young Men
While eating disorders in males are often overlooked, up to 7 million men in the United States will experience an eating disorder in their lifetime.
- Conditions
- Body Image Disturbance, Eating Disorder Symptom, Eating Behavior, Dysmorphic Features
- Trial name
- NCT05258409
- Testing
- Media Advocacy (MA), More than Muscles (MTM)
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Auburn University
Somatization Disorder, Somatoform Disorders
Acceptance and Commitment Group Therapy for Adolescents With a Range of Functional Somatic Syndromes
Background: An increasing number of adolescents report recurrent functional somatic symptoms. Some experience persistent symptoms and may receive functional somatic syndromes (FSS) diagnoses (i.e.
- Trial name
- NCT02346071
- Testing
- Acceptance and Commitment Therapy, Enhanced Usual Care (EUC)
- Where
- Denmark
- Volunteers
- 91 people
- Sponsor
- University of Aarhus
Pain Syndrome
Midazolam Versus Dexamethasone as an Adjuvant to Local Anesthetics in the Ultrasound Guided Hydrodissection of Median Nerve for Treatment of Carpal Tunnel Syndrome Patients
midazolam and dexamethasone both can counteract chronic pain. either via GABA mimetic action or via anti prostaglandins
- Trial name
- NCT04527770
- Testing
- Dexamethasone, Midazolam injection
- Where
- Egypt
- Volunteers
- 134 people
- Sponsor
- Minia University
Chronic Pain, Post Intensive Care Unit Syndrome
The Post-ICU Pain Study
BACKGROUND: ICU survivors may experience serious psychological, physical and cognitive impairments following ICU admission, collectively termed Post Intensive Care Syndrome (PICS).
- Conditions
- Chronic Pain, Post Intensive Care Unit Syndrome, Quality of Life, Pain Disorder
- Trial name
- PIP (NCT07180407)
- Where
- 4 sites in Denmark
- Volunteers
- 800 people
- Sponsor
- Zealand University Hospital
Neuropathic Pain, HIV Neuropathy
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain
Distal sensory peripheral neuropathy (DSP) is a chronic, debilitating painful condition affecting quality of life in persons living with HIV.
- Conditions
- Neuropathic Pain, HIV Neuropathy, HIV/AIDS, Pain
- Trial name
- NCT03855111
- Testing
- Standard Acupuncture / Moxibustion, Individualized (Tailored) Active Acupuncture / Moxibustion
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- New York University
Pain Syndrome
Cervical Manual Therapy and Vagus Nerve Stimulation in Patients With Nonspecific Neck Pain
People with chronic neck pain are becoming more and more common in society every day.
- Trial name
- NCT06435364
- Testing
- Vagus nerve stimilation, Manual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Medipol University Hospital