Clinical trials: Medication Assisted Treatment
Opioid-use Disorder, HIV-1-infection
Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1
HIV infection, as well as exposure to opioids (including heroin), are associated with systemic immune activation including increased microbial translocation from the gut.
- Conditions
- Opioid-use Disorder, HIV-1-infection, Immune Activation, Inflammation
- Trial name
- AMOHI-1 (NCT04480554)
- Testing
- Methadone, Buprenorphine/naloxone, XR-Naltrexone
- Where
- 2 sites in United States, Vietnam
- Volunteers
- 78 people
- Sponsor
- University of Pennsylvania
Opioid-use Disorder
Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder
This proposal aims to determine whether an adjunctive Mindfulness-Based Relapse Prevention (MBRP) treatment program improves Medication Assisted Treatment (MAT) adherence and reduces drug-use among opioid use disorder (OUD)…
- Trial name
- NCT05042388
- Testing
- Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- West Chester University of Pennsylvania
Opioid-use Disorder, Medication Assisted Treatment
Minds and Mentors Program (MiMP)- R61
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of a twelve- week mindfulness based relapse prevention protocol in combination with peer mentoring in…
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Substance Use Disorders
- Trial name
- MiMP (NCT04233671)
- Testing
- Mindfulness based relapse prevention and peer mentoring
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Opioid-use Disorder, Overdose
Rapid Initiation of Drug Treatment Engagement
The proposed research will evaluate the ability of a mobile, rapid induction procedure to engage individuals in ongoing medication assisted treatment.
- Trial name
- RIDE (NCT03908437)
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Pennsylvania
Acute Pain
Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery
The purpose of this study is to determine the effectiveness and safety of single intravenous doses of the kappa opioid agonist CR845 in relieving pain in patients following laparoscopic-assisted hysterectomy surgery.
- Trial name
- NCT00877799
- Testing
- CR845
- Where
- 12 sites in United States
- Volunteers
- 114 people
- Sponsor
- Cara Therapeutics, Inc.
Breast Cancer, Peripheral Neuropathy, Secondary to Drugs or Chemicals
Chemotherapy Induced Peripheral Neuropathy. Could Physical Therapy Help Treat Symptoms?
The cause of Chemotherapy-Induced Peripheral Neuropathy (CIPN) is still unknown. An estimated 55-60% of patients will experience lasting symptoms affecting function for years post-treatment.
- Trial name
- NCT02239601
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- CancerCare Manitoba
Opioid Medication Assisted Treatment
Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment
Opioid use disorder (OUD) is a major cause of illness and death among Veterans for which effective treatment is a major priority of the Veterans Health Administration (VHA).
- Trial name
- CONDUIT (NCT04178551)
- Testing
- Implementation Facilitation
- Where
- 11 sites in United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Opioid-use Disorder, Medication Assisted Treatment
Psychosocial Pain Management to Improve Opioid Use Disorder Treatment Outcomes
The purpose of this research study is to look at the effect of programs aimed at helping people manage chronic pain and medication treatment.
- Conditions
- Opioid-use Disorder, Medication Assisted Treatment, Chronic Pain
- Trial name
- Persist (NCT04433975)
- Testing
- Psychosocial Pain Management (PPMI), Enhanced Usual Care (EUC)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Opioid-use Disorder, Contingency Management
Usability Testing for the Reward-based Technology to Improve OUD Treatment
Millions of people in the US misuse opioids each year, leading to thousands of deaths and costing billions of dollars in total economic burden.
- Conditions
- Opioid-use Disorder, Contingency Management, Medication for Opioid-use Disorder
- Trial name
- OARSCM (NCT05159362)
- Testing
- Software Application
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Q2i, LLC
Atrial Fibrillation
A Study to Learn About the Effects of Medicines That Help in Thinning the Blood in People With Atrial Fibrillation (AF) Between 2016 and 2020 in France
The purpose of this study is to look at how many patients with AF had strokes, major bleeding and death in both people who had and had not taken any oral anticoagulant.
- Trial name
- SIFNOS (NCT05838664)
- Testing
- No OAC, VKA, apixaban
- Where
- France
- Volunteers
- 2,140,403 people
- Sponsor
- Pfizer
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Cocaine Dependence
A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
This study will investigate a treatment strategy in which a computer-assisted behavioral intervention will be used to help individuals stop their use of cocaine.
- Trial name
- NCT01986075
- Testing
- Computer-assisted behavior therapy, Mixed-Amphetamine Salts- Extended Release (MAS-ER)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- New York State Psychiatric Institute
Cardiovascular Diseases
Standard vs Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism
The study is an investigator-initiated trial comparing two different catheters (standard versus ultrasound assisted) for the treatment of acute high risk pulmonary embolism (blood clots in lung arteries with evidence or heart…
- Trial name
- NCT03086317
- Testing
- Standard Catheter-Directed Thrombolysis, Ultrasound-Accelerated Thrombolysis
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Insomnia
Reducing Use of Sleep Medications Assisted by a Digital Insomnia Intervention
Chronic insomnia is one of the most common health problems among Veterans and significantly impacts their health, function, and quality of life.
- Trial name
- SEDATIVE (NCT05027438)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Deprescribing
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation
Novel Smoking Cessation Drug for Schizophrenia
The investigators will evaluate effects of a novel drug that improves nicotinergic receptor function vs. placebo on short-term smoking abstinence in smokers with schizophrenia who have a high interest in quitting.
- Trial name
- TRENDS (NCT02230384)
- Testing
- Active JNJ Drug
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- K.N. Roy Chengappa
Post-operative Situation
Study of a Prototype Software to Help Surgical Patients Manage Their Pain Medication
The experimental medical device is a prototype software. The device comes in the form of a smartphone with a touch interface. The smartphone used to support the software is a commercial smartphone marked CE.
- Trial name
- MORPHEE 2 (NCT05707247)
- Testing
- software
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Strasbourg, France
Obsessive-Compulsive Disorder
Effectiveness of D-Cycloserine as an Aid to Enhance Learning for Individuals With OCD Receiving Behavior Therapy
This study will assess the effectiveness of Seromycin (D-cycloserine) in enhancing the positive effects of behavior therapy for people with Obsessive-Compulsive Disorder (OCD).
- Trial name
- NCT00182000
- Testing
- seromycin, Behavior Therapy
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Post-Cesarean Pain, Cesarean Section Complications
Postoperative Dexamethasone on Post-Cesarean Pain
Investigating if giving post-operative dexamethasone to patients with a history of opioid use disorder on medication assisted treatment during pregnancy improves their pain scores and decreases their opioid use after cesarean…
- Trial name
- NCT04067609
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Opioid Use Disorder
Reward-based Technology to Improve OUD Treatment
Millions of people in the US misuse opioids each year. Medication assisted treatment (MAT) for opioid use disorder (OUD) is highly efficacious, but only a fraction of OUD persons access MAT, and treatment non-adherence is common…
- Trial name
- OARSCM (NCT05180669)
- Testing
- OARSCM Software Application, MyMAT Software Application
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Q2i, LLC
Pancreatic Ductal Adenocarcinoma, Pain, Acute
Ketamine-assisted Therapy for Advanced GI Cancer
This clinical trial evaluates whether it is possible to use a single dose of ketamine in combination with talk therapy to treat moderate to severe demoralization in patients with stage 3 or 4 gastrointestinal (GI) cancers who…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Pain, Acute, Gastrointestinal Cancers, Demoralization
- Trial name
- NCT06077487
- Testing
- Ketamine, Ketamine Injectable Product, Meaning and Purpose therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brian Anderson, MD