Clinical trials: Medication Management
Prolonged QT Interval in EKG and Sudden Death
Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
Female sex is an independent risk factor for the potentially fatal drug-induced arrhythmia (irregular heartbeat) known as torsades de pointes (TdP), which is associated with prolongation of the corrected QT (QTc) interval on the…
- Trial name
- NCT01929083
- Testing
- Progesterone, Ibutilide
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy
This Study Tests Whether Taking the Medicines Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills. The Study is Done in Healthy Men and Women and Measures the Amount of Each Medicine in the Blood
To establish the bioequivalence of one fixed dose combination (FDC) tablet of empagliflozin/linagliptin/metformin extended release (XR) versus the free combination of empagliflozin tablet, linagliptin tablet, and metformin XR…
- Trial name
- NCT03259490
- Testing
- Empagliflozin/linagliptin/metformin HCl, Empagliflozin, Linagliptin
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Hypertension
Renal Denervation for Management of Drug-Resistant Hypertension
INSPiRED is a multicenter parallel-group trial comparing usual medical treatment (control group) or usual medical treatment plus renal denervation (intervention).
- Trial name
- INSPiRED (NCT01505010)
- Testing
- Renal denervation
- Where
- 2 sites in Belgium
- Volunteers
- 17 people
- Sponsor
- KU Leuven
Primary Progressive Multiple Sclerosis
A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo
This Phase 2 study is intended to serve as a proof of concept for potential treatment with laquinimod in patients with PPMS. The study is also aimed at evaluating 2 doses of laquinimod in this population.
- Trial name
- ARPEGGIO (NCT02284568)
- Testing
- Laquinimod
- Where
- 99 sites in United States, Canada and 8 more
- Volunteers
- 374 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Erosive Esophagitis
Efficacy and Safety of Oral Once-Daily Vonoprazan (TAK-438) in Participants With Erosive Esophagitis
The purpose of the study is to demonstrate the efficacy of vonoprazan (TAK-438) versus lansoprazole in the treatment of erosive esophagitis classified as Los Angeles (LA) classification grades A to D at Week 8.
- Trial name
- NCT02388724
- Testing
- Vonoprazan, Lansoprazole
- Where
- 64 sites in China, Malaysia and 2 more
- Volunteers
- 481 people
- Sponsor
- Takeda
Analgesia After ED Discharge for Extremity Injuries
Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge
There will be 3 randomized, double-blinded clinical trials to help determine which of commonly prescribed oral opioid combination is most effective in managing acute extremity pain after discharge from the adult emergency…
- Trial name
- NCT01402375
- Testing
- Hydrocodone (first trial), Codeine (first trial), Oxycodone (for second trial)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Montefiore Medical Center
Depression in Adolescence
Evaluation of MoodRing on Improving the Quality of Depression Management in Adolescents
The MoodRing intervention is a mobile application for adolescents, parents, and an accompanying web-based clinician portal which enables adolescents to monitor their mood through the use of passively collected smartphone data.
- Trial name
- TECH-E (NCT05376358)
- Testing
- MoodRing App, Usual Care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ana Radovic
Medication Management
Discharge Medication Counseling in Hospitalized Children
Our objective is to design and test the efficacy of a health-literacy-informed discharge medication counseling intervention in the inpatient setting to reduce medication dosing errors and improve adherence in hospitalized…
- Trial name
- NCT05143047
- Testing
- Medication counseling
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
HIV, AIDS
Resistance Testing to Improve Management of Virologic Failure in Sub-Saharan Africa
The study design is an open-label, randomized controlled trial. The study will be conducted at study sites in Uganda and South Africa.
- Trial name
- REVAMP (NCT02787499)
- Testing
- HIV-1 RNA Resistance Testing
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 840 people
- Sponsor
- Massachusetts General Hospital
Metabolic Syndrome X
Diurnal Variation of Plasminogen Activator Inhibitor-1
To determine if nighttime administration of an aldosterone antagonist would effectively lower peak plasma Plasminogen Activator Inhibitor-1 (PAI-1) levels more effectively than morning administration.
- Trial name
- NCT00515021
- Testing
- Eplerenone (Morning), Eplerenone (Night-time)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2
Safety and Efficacy of Linagliptin (BI 1356) Plus Metformin in Type 2 Diabetes, Factorial Design
The objective of the randomised part of the study is to investigate the efficacy and safety of BI 1356 plus metformin compared to BI 1356 or metformin alone given for 24 weeks to drug naive or previously treated (4 weeks…
- Trial name
- NCT00798161
- Testing
- BI 1356, BI 1356 + metformin, Metformin
- Where
- 138 sites in Canada, Croatia and 12 more
- Volunteers
- 857 people
- Sponsor
- Boehringer Ingelheim
COPD, COPD Exacerbation Acute
ProAir Digihaler in COPD Disease Management: A Real World Study
A pilot study to explore the utilization of the TEVA ProAir Digihaler rescue medication use and inhalation parameters to identify disease deterioration to help in the management of COPD patients in clinical practice.
- Trial name
- NCT04821869
- Testing
- ProAir Digihaler, Digihaler
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Pulmonary Research Institute of Southeast Michigan
Glaucoma
The Support, Educate, Empower (SEE) Program
This study will test whether the Support, Educate, Empower (SEE) personalized Glaucoma Coaching Program improves eye drop medication adherence among glaucoma patients compared to enhanced standard care in a randomized controlled…
- Trial name
- SEE (NCT04735653)
- Testing
- Personalized Glaucoma Coaching, Enhanced Standard care
- Where
- 2 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Michigan
Chronic Pain
Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Opioid-related Side Effects
This study compares two different ways to treat pain. The two ways are: 1. continuing to take current pain medication(s) or 2. receiving morphine, a pain medication from a drug pump (a system to deliver drug to your body) that is…
- Trial name
- CONVERT-TDD (NCT01924182)
- Testing
- SynchroMed Infusion System and Intrathecal Morphine Sulfate, Conventional Medicine
- Where
- 6 sites in United States
- Volunteers
- 7 people
- Sponsor
- MedtronicNeuro
Drug Overdose, Virtual Reality
Use of Virtual Reality for Overdose Management Educational Trainings
This cluster-randomized trial will compare changes in attitudes and knowledge on administering naloxone based on exposure to either a virtual reality educational training or the current standard educational trainings (e.g.
- Trial name
- NCT04091659
- Testing
- Virtual Reality Education, Standard Education
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes
Harnessing Health IT for Self-Management Support and Medication Activation in a Medicaid Health Plan
To measure the effects of a Medical health plan-directed automated telephone self-management support system (ATSM) on patient outcomes among ethnically diverse health plan enrollees with diabetes.
- Trial name
- SMARTSteps (NCT00683020)
- Testing
- ATSM Intervention
- Where
- United States
- Volunteers
- 362 people
- Sponsor
- University of California, San Francisco
Pain
Effect of Acupuncture and Pain Medication on Radicular Pain Using QST
In this aim, we propose to conduct a double blinded, placebo-controlled, and randomized clinical trial to compare the clinical effectiveness of radicular pain relief by either acupuncture therapy or a course of pain medication…
- Trial name
- NCT01678586
- Testing
- Acupuncture, Gabapentin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus
Effect of Insulin Degludec Versus Insulin Glargine on Glycemic Variability in Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is characterized by wide fluctuations of glucose. The long-acting insulin has showed to improve glycemic variability however the behavior of insulin glargine versus insulin degludec is unknown.
- Trial name
- Diabetes (NCT02680457)
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- University of Guadalajara
Healthy
Bioequivalence of Two Different Capsule Types of Dabigatran
The objective of this Phase I trial is to demonstrate the bioequivalence of two capsules of dabigatran etexilate made from two different drug product batches.
- Trial name
- NCT01290757
- Testing
- Dabigatran etexilate
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Airway Control
Observational Study of Rapid Sequence Intubation Drug Delivery Using Intraosseous and Intravenous Access.
This study will evaluate using intraosseous vascular access and intravenous vascular access to give patients the necessary medications to perform rapid sequence intubation, for patients with airway difficulties.
- Trial name
- NCT01486407
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Vidacare Corporation