Clinical trials: Medication Management, open to volunteers
Hypertension, Self-Management
OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)
Hypertension (HTN) has a greater impact on African Americans (AA) than any other U.S. racial group. Uncontrolled blood pressure (BP) contributes to higher rates of disability, death, and health resource use among AA.
- Conditions
- Hypertension, Self-Management, Technology, Quality of Life
- Trial name
- NCT05293756
- Testing
- OPTIMA-BP Intervention
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Case Western Reserve University
Medication Adherence, Quality of Life
ECHO-COPD: Impact of a Pharmacist-Led Health Belief Model-Based Educational Intervention Among Chronic Obstructive Pulmonary Disease Patients
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease associated with substantial morbidity and mortality, impaired quality of life, and healthcare costs.
- Conditions
- Medication Adherence, Quality of Life, Cost, Health Belief Model
- Trial name
- ECHO-COPD (NCT07815353)
- Testing
- Pharmacist-Led HBM-Based Educational Intervention
- Where
- Saudi Arabia
- Volunteers
- 140 people
- Sponsor
- Rabia Hussain
Sleep Disorders
Optimization of Melatonin Administration in Healthy Adults
The goal of this clinical trial is to evaluate whether the timing and dosage of exogenous melatonin can improve sleep onset and maintenance in healthy adults aged 18-45 years (50% female) with no history of sleep disorders.
- Trial name
- MelOpt (NCT07514507)
- Testing
- Mel 2 mg 30 min, Mel 2 mg 3 h, Mel 4 mg 30 min
- Where
- Italy
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Non ST-Segment Elevation Myocardial Infarction
Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.
Inflammation plays a central role in the pathophysiology of atherosclerosis and in the progression of coronary artery. Colchicine, an anti-inflammatory agent traditionally used for gout and pericarditis, has emerged as a…
- Trial name
- NCT07143136
- Testing
- Colchicine
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Assiut University
Acute Admitted Multimorbid Patients
Poland Integrated Medicines Management (PL-IMM) - Study Assessing the Provision of Complex Clinical Pharmacy Services to Hospitalized Patients
The aim of the study is to assess whether the involvement of a clinical pharmacist in patient care at every stage of hospitalization, from admission to discharge, will improve the quality of healthcare services provided in…
- Trial name
- PL-IMM (NCT07159932)
- Testing
- multidisciplinary treatment
- Where
- Poland
- Volunteers
- 610 people
- Sponsor
- Wroclaw Medical University
Cardiovascular Diseases (CVD), Drug Effect
Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial
Statins inhibit hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase which catalyzes the rate-limiting step in cholesterol synthesis.
- Conditions
- Cardiovascular Diseases (CVD), Drug Effect, Atherosclerosis Cardiovascular Disease
- Trial name
- STATIN-C3 (NCT06856772)
- Testing
- Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
- Where
- Denmark
- Volunteers
- 42,000 people
- Sponsor
- Tor Biering-Sørensen
Anterior Shoulder Dislocation
METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation (HYPNOLUX)
Anterior shoulder dislocation is a pathology frequently encountered in emergency medicine. The success in reducing anterior shoulder dislocations depends on muscle relaxation, which is itself conditioned by the patient's pain and…
- Trial name
- NCT05821517
- Testing
- Helmet virtual reality., Administration of METHOXYFLURANE, Standard of care
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Coronary Artery Disease, Diabete Mellitus
Assessment and Management of Multiple Drug Use in Elderly Chronic Disease Patients
The purpose of this observational study is to understand the impact of polypharmacy on the prognosis of elderly patients with chronic diseases.
- Conditions
- Coronary Artery Disease, Diabete Mellitus, Chronic Kidney Disease, Hypertension
- Trial name
- NCT07180368
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Neoplasms, Chemotherapy-induced Nausea and Vomiting
Serious Gaming for Chemotherapy-induced Nausea and Vomiting
The purpose of this study is to examine the effectiveness of a technology-based intervention for managing nausea and vomiting in older adults with cancer.
- Trial name
- NCT05838638
- Testing
- eSSET-CINV
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Central Florida
Procedure-Related Pain, Acute Pain
Virtual Reality Intervention to Reduce Pain in Women Undergoing Elective Oocyte Cryopreservation
This randomized controlled study evaluates whether exposure to relaxing virtual reality (VR) scenery prior to oocyte retrieval can reduce pain in women undergoing elective oocyte cryopreservation.
- Trial name
- OPU-VR (NCT07484815)
- Testing
- Virtual reality relaxation intervention, Standard Care Control
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Early-Onset Type 2 Diabetes
Precision Diabetes Management: Integrated East-West Approach
This project will leverage a large-scale cohort of early-onset type 2 diabetes patients to conduct innovative prospective clinical research.
- Trial name
- NCT07307040
- Testing
- No interventions
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
To Compare the Time Required to Administer 1 mg of Epinephrine, as Well as the Total Procedure
Vascular Access and Intraosseus
Rapid administration of epinephrine is an essential component of advanced life support during cardiac arrest. Peripheral intravenous (IV) access is commonly used for drug delivery, while intraosseous (IO) access is an alternative…
- Trial name
- IO_nursing (NCT07471555)
- Testing
- Epinephrine Ampoule (Manual Preparation), Epinephrine Prefilled Syringe (Ready-to-use), Intravenous (IV) Access
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Focal Epilepsy, Generalized Seizure
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
Mayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications.
- Conditions
- Focal Epilepsy, Generalized Seizure, Drug Refractory Epilepsy
- Trial name
- FORESITE (NCT07012148)
- Testing
- UNEEG SubQ device, seizure forecasts, nasal diazepam, Preventative Medication (PM)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Chronic Low-back Pain (cLBP), High-Impact Chronic Pain (HICP)
Comparing Non-Medicine Strategies for Improving Low Back Pain
The goal of this clinical trial is to help veterans manage high-impact chronic pain (HICP) in the lower back. The trial will use a program, ENCompaSS (Education, Navigated Care, and Supported Self-Management) designed to reduce…
- Trial name
- NCT07679178
- Testing
- ENCompaSS (Education, Navigated Care, and Supported Self-Management) with VA Stepped Usual Care
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Duke University
Cardiovascular Diseases, Cardiac Rehabilitation
SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation
The study is sponsored by the National Heart, Lung, and Blood Institute, which is part of the National Institutes of Health. The study expects to enroll 400 subjects.
- Trial name
- EMPOWER ME (NCT06886789)
- Testing
- Text Messaging, Fully Automated Online Program, Low-Intensity Cardiac Rehabilitation Maintenance Program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The Miriam Hospital
Critical Illness, Surgical Procedure, Unspecified
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill.
- Conditions
- Critical Illness, Surgical Procedure, Unspecified, Pulmonary Aspiration, Fasting
- Trial name
- FEEDS (NCT06751043)
- Testing
- Fasting, Not fasting
- Where
- 19 sites in United States
- Volunteers
- 1,072 people
- Sponsor
- Massachusetts General Hospital
Multiple Myeloma or Amyloidosis
Prospective Evaluation of Subcutaneous Administration of Daratumumab by the FreedomEDGE® Infusion System
This study is evaluating a new method for administering daratumumab, a treatment commonly used in the management of multiple myeloma and amyloidosis.
- Trial name
- ESCAPE (NCT07721350)
- Testing
- Subcutaneous Daratumumab Administration Using FreedomEDGE®
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
X-linked Hypophosphatemia (XLH)
Effective Dosing of Burosumab in XLH
X-linked hypophosphataemia (XLH) is a rare, hereditary condition. The genetic defect leads to low blood phosphate levels and vitamin D suppression. Phosphate is required for strong bones and teeth and to store energy in cells.
- Trial name
- NCT07183579
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Nottingham
Medication Adherence, Medication Safety
Evaluation of Medication Management Service
Medication management services (MMS) is a pharmacist-led service of optimizing the medication use and health outcomes, by promoting medication safety and enhancing the ability in self-management of health and diseases of patients…
- Conditions
- Medication Adherence, Medication Safety, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- NCT06273761
- Testing
- Medication Management Service (MMS)
- Where
- 8 sites in Hong Kong
- Volunteers
- 640 people
- Sponsor
- The University of Hong Kong
Seizure Recurrence
Mobile Video Education and Machine Learning-Based Risk Prediction in Neonatal Seizure Management
This mixed-methods study will develop a machine learning-based model to identify infants at high risk of seizure recurrence after discharge from the neonatal intensive care unit.
- Trial name
- NCT07695623
- Testing
- Mobile Video-Supported Education
- Volunteers
- 60 people
- Sponsor
- Istanbul Saglik Bilimleri University