Clinical trials: Medication to Treat Opioid Use Disorder
Substance-Related Disorders
Reducing Drug Use in Justice-Involved Emerging Adults
The overarching purpose of this pilot study is to investigate an increasingly common, but under-researched, practice of employing paraprofessional coaches to improve emerging adults' access to and engagement in evidence-based…
- Trial name
- PEERS (NCT05834881)
- Testing
- Contingency Management (CM) combined with vocational/educational coaching
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Opioid-Related Disorders, Substance-Related Disorders
Extended-release Buprenorphine Compared to Sublingual Buprenorphine in Rural Settings (RXR)
This pilot trial will explore the feasibility, acceptability, and effectiveness of the most recently approved formulation of injectable extended-release buprenorphine (XR-BUP) for treatment of opioid use disorder (OUD) in rural…
- Conditions
- Opioid-Related Disorders, Substance-Related Disorders, Narcotic-Related Disorders
- Trial name
- RXR (NCT06023459)
- Testing
- Injectable extended-release buprenorphine, Sublingual buprenorphine-naloxone
- Where
- 7 sites in United States
- Volunteers
- 140 people
- Sponsor
- Yih-Ing Hser
Opioid-use Disorder, Contingency Management
Usability Testing for the Reward-based Technology to Improve OUD Treatment
Millions of people in the US misuse opioids each year, leading to thousands of deaths and costing billions of dollars in total economic burden.
- Conditions
- Opioid-use Disorder, Contingency Management, Medication for Opioid-use Disorder
- Trial name
- OARSCM (NCT05159362)
- Testing
- Software Application
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Q2i, LLC
Opioid-use Disorder
Medication Maintenance Therapy in Community Pharmacy Settings
The goal of this study is to examine how the pharmacy can better optimize treatment expansion by providing pharmacy-based medication assisted treatment (MAT) for maintenance under a collaborative pharmacy practice agreement.
- Trial name
- MATPharm (NCT03766893)
- Testing
- Buprenorphine / Naloxone Oral Product, injectable naltrexone, Pharmacy maintenance addiction care
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Lifespan
Substance Abuse, HIV
Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System
Women involved in the carceral system (WICS) are at higher risk for both HIV and substance use than the general public. WICS are also more likely to engage in behaviors both before and after release that put them at risk for HIV…
- Trial name
- PA-Links (NCT07432555)
- Testing
- Tool to provide re-entry support and improve linkage to healthcare and social services
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Temple University
Opioid-use Disorder
Examining an Adaptive Approach to Providing Psychosocial Support to Buprenorphine Patients
The purpose of this study is to address important knowledge gaps regarding the optimal way to provide psychosocial treatment to patients who are receiving buprenorphine for opioid use disorder (OUD) in office-based settings.
- Trial name
- NCT04650386
- Testing
- Psychosocial support determined by adaptive treatment algorithm
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Public Health Management Corporation
Hepatitis C
Hepatitis C Pharmacy-based Strategy for Injectors
The aim of this study is evaluate the acceptability/usage of a newly implemented model of delivery of care, namely a community-pharmacy program, to provide access to medications to treat hepatitis C (HCV), and prevent overdose…
- Trial name
- HepPSI (NCT04698629)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Opioid-use Disorder
Mindfulness-Based Relapse Prevention to Improve Medication Assisted Treatment Adherence and Drug-use Outcomes for Opioid Use Disorder
This proposal aims to determine whether an adjunctive Mindfulness-Based Relapse Prevention (MBRP) treatment program improves Medication Assisted Treatment (MAT) adherence and reduces drug-use among opioid use disorder (OUD)…
- Trial name
- NCT05042388
- Testing
- Mindfulness-Based Relapse Prevention - Rolling Admission (MBRP-RA), Treatment-As-Usual
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- West Chester University of Pennsylvania
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Opioid Dependence, Injection Drug Use
Pilot Test of a Community-based Buprenorphine Treatment Intervention
The main goal of this study is to pilot test the community-based buprenorphine treatment (CBBT) intervention, examining buprenorphine treatment initiation, opioid use, and HIV risk behaviors.
- Trial name
- NCT01761110
- Testing
- Community-based buprenorphine treatment (CBBT) intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Albert Einstein College of Medicine
Substance Use Disorders
Implementation and Evaluation of SBIRT
Alarming rates of unhealthy alcohol, non-prescription drug, and tobacco use highlight the preventable health risks of substance abuse and the urgent need to advance behavioral health systems.
- Trial name
- NCT03560076
- Testing
- SBIRT Training and Implementation Strategies
- Where
- United States
- Volunteers
- 2,562 people
- Sponsor
- Indiana University
Analgesics, Antipyretics and Anti-Inflammatory Drugs Causing Adverse Effects in Therapeutic Use
Developing a Method to Objectively Measure Opioid Analgesia
Inappropriate prescribing is the fundamental upstream driver of the opioid epidemic. Objective measures to determine the appropriateness of an opioid intervention, provide monitoring of the therapy for adequacy of dose and…
- Trial name
- NCT03605966
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Julia Finkel
Opioid Use Disorder
Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2).
The purpose of the study is to assess drug-drug interaction (DDI) and safety of AZD4041 and itraconazole in healthy participants (Part 1), and to assess efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD404…
- Trial name
- NCT06406400
- Testing
- AZD4041, Itraconazole, Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- AstraZeneca
Addiction, Opioid
Stagewise Implementation-To-Target- Medications for Addiction Treatment (SITT-MAT)
The purpose of this study is to expand access to medications for opioid use disorder (MOUD) in specialty addiction programs in Washington State.
- Trial name
- SITT-MAT (NCT05343793)
- Testing
- Enhanced Monitoring and Feedback (EMF), NIATx/MAT Academy, NIATx-Internal Facilitation (NIATx-IF)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Stanford University
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Opioid Use Disorder
Medications for Opioid Use Disorders (MOUD) Via Telemedicine
Medication Assisted Treatment (MAT) of Veterans with Opioid Use Disorder (OUD) decreases mortality and improves treatment follow-up.
- Trial name
- NCT03566459
- Testing
- CBOC offering Tele-MOUD to Veterans, CBOC not offering Tele-MOUD to Veterans
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Alcohol Use Disorder, Alcoholism
fNIRs-based Neurofeedback to Reduce Relapse in pOUD/AUD
This study will examine the impact of functional near-infrared spectroscopy-based neurofeedback to a region within the brain's prefrontal cortex involved with self-regulation of resisting craving in alcohol use and prescription…
- Conditions
- Alcohol Use Disorder, Alcoholism, Prescription Drug Dependence, Opioid-use Disorder
- Trial name
- NCT03595293
- Testing
- fNIRs-based Neurofeedback
- Sponsor
- Milton S. Hershey Medical Center
Opioid Use Disorder
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder.
- Trial name
- NCT06323824
- Testing
- Methadone, Buprenorphine (BUP)
- Where
- 6 sites in United States
- Volunteers
- 600 people
- Sponsor
- Yale University