Clinical trials: Medication to Treat Opioid Use Disorder
Opioid Use Disorder
Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment
The goal of this clinical trial is to learn if receiving peer recovery support (support services provided by trained "peers" with lived experience of addiction and recovery) improves retention in medication treatment among people…
- Trial name
- PEERS (NCT07197801)
- Testing
- Peer recovery support to enhance patient engagement in medication for opioid use disorder treatment
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Geisinger Clinic
Opioid Use Disorder, Chronic Pain
An Adaptive Walking Intervention to Manage Chronic Pain in Veterans With Opioid Use Disorder Engaged in Opioid Agonist Treatment
Severe chronic pain and opioid use disorder (OUD) occur at significantly higher rates in Veterans compared to the general population.
- Trial name
- NCT05051644
- Testing
- Steps 2 Change (S2C), Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails
Opioid overdose is the leading cause of death among people recently released from incarceration. Recent evidence also shows a rise in stimulant use among justice-involved populations, as well as growing rates of concurrent opioid…
- Conditions
- Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder
- Trial name
- HOPE (NCT07490717)
- Testing
- Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
- Where
- 2 sites in United States
- Volunteers
- 338 people
- Sponsor
- University of Arkansas
Opioid Use Disorder
Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial
The goal of this clinical study is to evaluate a new treatment approach called symptom inhibited naloxone induction (SINI) for people with opioid use disorder.
- Trial name
- NCT07439549
- Testing
- Naloxone Hydrochloride 0.4 MG/ML, Buprenorphine hydrochloride and naloxone hydrochloride dihydrate sublingual tablet (2 mg/0.5 mg and 8 mg/2 mg), Buprenorphine extended-release injection (300 mg/1.5 mL)
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- Pouya Azar
Opioid-use Disorder
Mindful Body Awareness With Medication Treatment for Opioid Use Disorder
The national opioid epidemic requires development of real-world evidence-based treatments for opioid use disorder, including adjuncts to Medication for Opioid Use Disorder (MOUD).
- Trial name
- NCT04082637
- Testing
- Mindful Awareness in Body-oriented Therapy
- Where
- 5 sites in United States
- Volunteers
- 303 people
- Sponsor
- University of Washington
Opioid-use Disorder
Effectiveness of a CBT-based mHealth Intervention Targeting MOUD Retention, Adherence, and Opioid Use
The focus of this study is to examine the effectiveness of imFREE relative to mHealth ED in facilitating treatment retention and adherence and reducing opioid use among adults with OUD initiating BUP treatment.
- Trial name
- UCimFREE (NCT04808479)
- Testing
- imFREE mCBT, mHealth ED
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of California, Los Angeles
Stimulant Use Disorder
Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment
This project will evaluate the ability of Mirtazapine (MZP), a pharmacologically unique medication with a growing body of evidence to support its efficacy and safety for the treatment of methamphetamine (MA) use among medication…
- Trial name
- MIRROM (NCT06323837)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Washington State University
Opioid-use Disorder, Addiction
Collaboration Leading to Addiction Treatment and Recovery From Other Stresses
Collaboration Leading to Addiction Treatment and Recovery from Other Stresses (CLARO) is a five-year project that tests whether delivering care using a collaborative model helps patients with both opioid use disorders and mental…
- Conditions
- Opioid-use Disorder, Addiction, Depression, Post-traumatic Stress Disorder
- Trial name
- CLARO (NCT04559893)
- Testing
- Collaborative Care
- Where
- 16 sites in United States
- Volunteers
- 729 people
- Sponsor
- RAND
Depression, Anxiety
More Individualized Care: Assessment and Recovery Through Engagement
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time.
- Conditions
- Depression, Anxiety, Opioid-Related Disorders, Pain, Chronic
- Trial name
- MI-CARE (NCT05122676)
- Testing
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
- Where
- 2 sites in United States
- Volunteers
- 805 people
- Sponsor
- Kaiser Permanente
Opioid-use Disorder
Opioid Treatment and Peer Recovery Support
Determine whether a facilitated local change team intervention improves a probation organization's client-level medication for opioid use disorder (MOUD) outcomes and implementation outcomes relative to baseline across multiple…
- Trial name
- JCOIN (NCT04978168)
- Testing
- Core Intervention, Peer Support Specialists (PSS), Treatment as Usual (TAU)
- Where
- 3 sites in United States
- Volunteers
- 164 people
- Sponsor
- Brown University
Opioid-use Disorder
Medication Maintenance Therapy in Community Pharmacy Settings
The goal of this study is to compare pharmacy-based medication assisted treatment (MAT) with usual care MAT for people with opioid use disorder.
- Trial name
- MATPharm (NCT04139213)
- Testing
- buprenorphine/naloxone oral product, injectable naltrexone, Pharmacy maintenance addiction care
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Lifespan
Substance Use Disorder
Virtual MOUD Treatment- Virtual POC Toxicology
Care for Substance use disorders (SUD) such as Medication treatment of Opioid Use Disorder (MOUD) saves lives and is increasingly delivered virtually. Currently, 60% of VA outpatient addiction treatment occurs over video.
- Trial name
- NCT05448118
- Testing
- Virtual POC Toxicology Test
- Where
- 2 sites in United States
- Sponsor
- VA Office of Research and Development
Opioid Use, Constipation Drug Induced
Study on Quality of Life in Advanced Cancer Patients With Opioid-induced Constipation Treated With Naloxegol
Opioid-Induced Constipation (OIC) is often associated with a compromised quality of life of patients in palliative care (PC) setting.
- Conditions
- Opioid Use, Constipation Drug Induced, Cancer
- Trial name
- NCT04294550
- Testing
- Naloxegol
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione ANT Franco Pannuti ETS
Opioid Use Disorder
PEERS Pilot: Peer Recovery Support Program to Support Engagement in Medication for Opioid Use Disorder
The goal of this pilot study is to evaluate the feasibility and acceptability of implementing a peer recovery support program to support patient engagement in medication treatment for opioid use disorder (MOUD).
- Trial name
- PEERS (NCT06696066)
- Testing
- PRS Program
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Geisinger Clinic
Opioid Use
FOREward Together: Training Peer Recovery Coaches to Promote Retention and Adherence to MOUD
This project aims to implement a peer-led intervention to support retention and adherence to medications for opioid use disorder among low-income adults in Detroit, as well as a training manual for peer recovery coaches serving…
- Trial name
- NCT05098795
- Testing
- Behavioral Activation (BA)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Henry Ford Health System
Opioid Use Disorder, Opioid Overdose
A Bundled Intervention to End Opioid Overdoses
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT07485335)
- Testing
- Bundled intervention (Experimental), control group, Buprenorphine (Experimental)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Alabama at Birmingham
Opioid Use, Opioid Use Disorder
Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP
The purpose of this study is to provide medication for opioid use disorder (MOUD) with buprenorphine and naloxone, or bup/nx, pre-exposure prophylaxis (PrEP) for HIV prevention, and/or hepatitis C treatment for persons who inject…
- Conditions
- Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv
- Trial name
- PARTNERUP (NCT05108935)
- Testing
- Suboxone, Truvada, Mavyret
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Opioid Use Disorder, Opioid Use Disorder, Moderate
TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization
The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized patients with OUD deemed to be good candidates for MOUD by the UCMC…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- TRTME (NCT07780097)
- Testing
- TRTME
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- T. John Winhusen, PhD
Drug Use Disorders, Drug Abuse
Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks
Background: Sixty million American adults suffer from moderate to severe chronic pain. Of these, 5 to 8 million currently use opioids long-term.
- Conditions
- Drug Use Disorders, Drug Abuse, Drug Addiction, Drug Dependence
- Trial name
- CARE (NCT02224508)
- Volunteers
- 1,588 people
- Sponsor
- Kaiser Permanente