Clinical trials: Medicine Regimen
HIV Infections
Metabolic Effects of Non-Thymidine Analogue Anti-HIV Medications
The purpose of this study is to observe the effects of certain anti-HIV medications on mitochondrial activity and fat cell death.
- Trial name
- NCT00433992
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Anti-HIV Drug Regimens With or Without Protease Inhibitors and Drug Level Monitoring in HIV Infected Adolescents
The purpose of this study is to compare the effectiveness of anti-HIV drug regimens with or without a protease inhibitor (PI) in HIV infected adolescents.
- Trial name
- NCT00075907
- Testing
- Efavirenz + 2 NRTIs, Lopinavir/Ritonavir + 2 NRTIs, Therapeutic Drug Monitoring
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Disease, Atrial Fibrillation
Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation
The investigators hypothesize that reducing the duration of clopidogrel therapy from 6 months to 6 weeks after DES implantation is associated with improved clinical outcomes in patients on ASA and an oral anticoagulant.
- Trial name
- ISAR-TRIPLE (NCT00776633)
- Testing
- aspirin, clopidogrel, oral anticoagulation
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 614 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Hepatitis C, Medication Adherence
Intensive Models of HCV Care for Injection Drug Users
Injection drug users (IDUs) constitute 60% of the approximately 5 million people in the U.S. infected with hepatitis C virus (HCV). HCV treatment leading to sustained viral response (SVR) is associated with increased survival.
- Trial name
- NCT01857245
- Testing
- Intensive Models (mDOT and CGT) of HCV Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Prisma Health-Upstate
Pathological Conditions, Signs and Symptoms
PTC Guiding Neoadjuvant Treatment in Breast Cancer
Patients with breast cancer meet criteria for enrollment are randomized into PTC group or control group. The neoadjuvant therapy regimens are guided by PTC test in the PTC group.
- Trial name
- NCT05103293
- Testing
- patient-derived tumor-like cell clusters drug sensitivity test
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Zhejiang Cancer Hospital
Lymphatic Filariasis
Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG
The standard regimen for elimination of lymphatic filariasis (LF) in PNG is annual administration of two drugs at the same time.
- Trial name
- MDA (NCT03268252)
- Where
- Papua New Guinea
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
PreDiabetes
The Effect of Traditional Chinese Medicine Regimen-based Lifestyle Mobile Health APP in Prediabetes
Prediabetes is a major risk factor for diabetes. The Lifestyle Modification Mobile Health Application (APP) could not only help to decrease blood sugar among individuals with prediabetes but it could also prevent a later…
- Trial name
- NCT04096989
- Testing
- Traditional Chinese medicine regimen-based lifestyle mobile health APP, Lifestyle mobile health APP
- Where
- Taiwan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Delirium
Impact of Various Sedation Regimens on the Incidence of Delirium
Sedation drugs that are commonly used in ICU in treatment of ARDS, includes propofol, midazolam and dexmedetomidine . Among these, both dexmedetomidine and propofol have been reported to be used together with midazolam in ICU and…
- Trial name
- NCT02117726
- Testing
- Dexmedetomidine,midazolam, Propofol,midazolam
- Where
- 7 sites in China
- Volunteers
- 320 people
- Sponsor
- Shandong Provincial Hospital
HIV Infections
Safety and Effectiveness of Four Anti-HIV Drug Combinations in HIV-Infected Children and Teens
The purpose of this study is to see if it is safe and effective to give HIV-infected children and teens 1 of 4 anti-HIV drug combinations. Decreasing HIV levels in infected patients can slow down disease progression.
- Trial name
- NCT00001091
- Testing
- Ritonavir, Nelfinavir mesylate, Nevirapine
- Where
- 55 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Trauma Patients
Commonly Used Drug Regimens for Rapid Sequence Intubation (RSI) of Trauma Patients in the Emergency Department
Airway is the first step in the initial assessment of a trauma patient. Often this assessment determines the need for endotracheal intubation, most commonly by rapid sequence intubation (RSI).
- Trial name
- NCT05243420
- Sponsor
- Methodist Health System
HIV Infections
A Study of Capravirine Plus VIRACEPT Plus Two Nucleoside Reverse Transcriptase Inhibitors in HIV-Infected Patients Who Failed Previous Anti-HIV Treatments
The purpose of this study is to see if the addition of capravirine to VIRACEPT (nelfinavir mesylate) plus 2 nucleoside reverse transcriptase inhibitors (NRTIs) is an effective combination drug therapy for HIV patients who have…
- Trial name
- NCT00006211
- Testing
- Capravirine, Nelfinavir mesylate
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Agouron Pharmaceuticals
AML, Adult
VAG Versus Standard Chemotherapy With FLT3 Inhibitor in Adult Patients With FLT3-Mutated AML
This is a multicenter, randomized, controlled, open-label phase III trial evaluating the efficacy and safety of the VAG regimen (azacitidine, venetoclax, and gilteritinib) compared with standard 3+7 chemotherapy (cytarabine plus…
- Trial name
- VAG-3+7-G (NCT07407140)
- Testing
- Gilteritinib + Azacitidine + Venetoclax, Cytarabine + Daunorubicin (or Idarubicin) + Gilteritinib, Re-induction Therapy
- Volunteers
- 300 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Coronary Artery Disease
EDUCATE: The MEDTRONIC Endeavor Drug Eluting Stenting: Understanding Care, Antiplatelet Agents and Thrombotic Events
EDUCATE is a prospective, multi-center study designed to collect real-world safety and clinical outcomes in subjects receiving one or more Endeavor Zotarolimus-Eluting Stents and either clopidogrel and aspirin or prasugrel and…
- Trial name
- EDUCATE (NCT01069003)
- Testing
- Thienopyridine Therapy, Surveillance Arm
- Where
- United States
- Volunteers
- 2,272 people
- Sponsor
- Medtronic Vascular