Clinical trials: Medicines Optimisation
Heart Failure with Reduced Ejection Fraction, Chronic Heart Failure
Efficacy of a Streamlined Heart Failure Optimization Protocol
The SHORT trial compares the current standard optimization protocol to a shortened protocol in a randomized control trial.
- Trial name
- SHORT (NCT05021419)
- Testing
- Streamlined protocol, Standard Protocol
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
Epilepsy
Intracerebral Electrical Stimulation and the Optimisation of Presurgical Planning in Drug-refractory Partial Epilepsy
Patients with drug-refractory epilepsy sometimes need to be implanted with intracerebral electrodes in order to identify their seizure onset zone.
- Trial name
- StiMiC (NCT03738072)
- Testing
- StiMiC stimulation condition
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Rheumatoid Arthritis
Adalimumab Drug Optimisation in Rheumatoid Arthritis Using Therapeutic Drug Monitoring
Several prior studies have shown that dose reduction of Tumor Necrosis Factor (TNF)-inhibitors like adalimumab is possible in substantial number of rheumatic disease patients without an increase in disease activity.
- Trial name
- ADDORA (NCT04194827)
- Testing
- Adalimumab serum trough concentration, Disease activity, Adalimumab
- Where
- Netherlands
- Volunteers
- 267 people
- Sponsor
- Reade Rheumatology Research Institute
Obstructive Sleep Apnoea, Sleep-Disordered Breathing
Drug-Induced Sleep Endoscopy for the Optimisation of Treatment of Patients With Obstruction Sleep Apnoea
The main diagnostic challenge in patients with OSA (obstructive sleep apnea) is to determine the location of obstruction of the upper airway during sleep.
- Trial name
- NCT02855515
- Testing
- Short-time diagnostic anaesthesia
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
HIV-1-infection
The Medicines Optimisation Review Toolkit Evaluation in HIV Outpatients
Multicentre, randomised (1:1), controlled, open (not blinded) comparison of MOR toolkit (intervention) with standard pharmaceutical care (control)
- Trial name
- MOR (NCT03340077)
- Testing
- Medicines Optimisation Review toolkit, Standard of Care
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Medicines Optimisation
Development of the Medicines Optimisation Assessment Tool
The purpose of this study is to develop a prediction-tool, the Medicines Optimisation Assessment Tool (MOAT), to assist hospital pharmacists identify patients at highest risk of preventable medication related problems (MRPs).
- Trial name
- MOAT (NCT02582463)
- Where
- United Kingdom
- Volunteers
- 1,552 people
- Sponsor
- University College, London
Antimicrobial Stewardship, Drug Resistance, Bacterial
Optimising Community Antibiotic Use and Infection Control With Behavioural Interventions in Burkina Faso and DR Congo
Emergence of antibiotic resistance (AMR) is a serious concern for Low and Middle Income Countries (LMICs). Unregulated use of antibiotics, a major AMR driver, is highly prevalent in LMICs, with medicine stores as key providers.
- Trial name
- CABU-B/C (NCT05378880)
- Testing
- Behavioural intervention bundle to optimise antibiotic use and reduce the risk of human-to-human or environmental-animal-human transmission
- Where
- 2 sites in Burkina Faso, Democratic Republic of the Congo
- Volunteers
- 5,532 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Parkinson Disease
Pharmacist-led Perioperative Medicines Optimisation
Patients attend pre-assessment clinics (POAC) who require an elective operation and who are having a general anaesthetic. At POAC patients are asked about their health, and past medical conditions to assess their fitness for…
- Trial name
- NCT04228770
- Testing
- Meeting with pharmacist
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust