Clinical trials: Medium-chain Triglyceride
Psoriatic Arthritis (PsA)
A Randomized, Double-blind Clinical Trial on the Efficacy of a Dietary Formulation Containing Medium-chain Triglycerides (MCT) and Fiber in Patients With Psoriatic Arthritis
The primary objective of this study is to evaluate the effects of a formulation containing medium-chain triglycerides (MCTs) and vegetable fibers on the quality of life of patients with psoriatic arthritis, by monitoring the…
- Trial name
- CALIPSO (NCT06990152)
- Testing
- MCTs and fiber
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Dr. Schär AG / SPA
Alzheimer's Disease
Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
- Trial name
- MCT-MA (NCT02709356)
- Testing
- 1-month of 60-40 MCT oil, 1-month of C8 MCT oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Biliary Atresia, Infant
High Medium-chain Triglyceride Nutritional Support in Infants With Biliary Atresia
This study is a prospective, single center and observational open clinical study.
- Conditions
- Biliary Atresia, Infant, Nutrition Support, Medium-chain Triglyceride
- Trial name
- NCT05072626
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Fudan University
Cholestasis, Growth Failure
SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury
While fish-oil lipid emulsions have shown a benefit to the treatment of parenteral nutrition (PN)-associated cholestasis, the dose is limited to 1 g/kg/day.
- Trial name
- SMOF (NCT02412566)
- Testing
- SMOFlipid
- Where
- United States
- Sponsor
- Baylor College of Medicine
Epilepsy, Intermittent Fasting
IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy
The objective of the prospective monocentric pilot trial is to investigate the influence of intermittent fasting with or without a once-daily intake with medium chain triglycerides (MCTs) on the frequency of seizures in patients…
- Trial name
- IF-MCT16:8 (NCT06013761)
- Testing
- IF 16:8 as active comparator vs. IF MCT 16:8 as experimental arm
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University Hospital Marburg
Alzheimer Disease
Medical Food Formulation Pharmacokinetic (PK) Study in Medium Chain Triglycerides
This is a Phase I, open label, randomized, 6-way crossover, pilot PK study
- Trial name
- NCT03635879
- Testing
- MCTprocal medical food, Milk/tricaprilin oil blend, AC-1207
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cerecin
First Episode Psychosis
Recovery With Exogenous Ketones and Antipsychotics
The RECAP project will evaluate the clinical and metabolic effects of adding exogenous ketones to antipsychotic (AP) treatment in young adults with a first episode of psychosis (FEP).
- Trial name
- RECAP (NCT07122531)
- Testing
- Medium chain triglyceride oil
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Lidocaine, Injection Pain
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated With Medium-/Long-chain Triglycerides
Propofol is widely used in general anesthesia induction, but the occurrence of peripheral intravenous pain is relatively high, causing anxiety, fear and other adverse emotions in patients , aggravating the stress response, and…
- Trial name
- NCT04008433
- Testing
- Lidocaine
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Metabolically Unhealty Obese, Dyslipidemia
Effect of a Low-Calorie MCT-Rich Traditional Minangkabau Diet on Obese Individuals
This study aims to investigate the effect of a low-calorie diet rich in medium-chain triglycerides (MCTs) based on traditional Minangkabau foods on metabolic biomarkers in individuals with obesity.
- Conditions
- Metabolically Unhealty Obese, Dyslipidemia, Diabetes (DM), Resistance, Insulin
- Trial name
- NCT07423884
- Testing
- Low-Calorie Diet Rich in Medium-Chain Triglycerides (MCTs) Based on Traditional Minangkabau Foods
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Andalas University
Primary Triglyceride Deposit Cardiomyovasculopathy (TGCV), Neutral Lipid Storage Disease With Myopathy (NLSD-M)
Clinical Study on the Safety of CNT-02 for TGCV and NLSD-M
This study is planning to evaluate the safety and clinical efficacy of medium-chain fatty acid capsules (food-grade CNT-02) in subjects with primary triglyceride deposit cardiomyovasculopathy (TGCV) and neutral lipid storage…
- Trial name
- NCT02830763
- Testing
- CNT-02
- Where
- 7 sites in Italy, Japan
- Volunteers
- 2 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Cholestasis, Jaundice, Obstructive
SMOFlipid to Lessen the Severity of Neonatal Cholestasis
Parenteral nutrition (PN) provides intravenous nutritional supplementation for infants unable to absorb adequate enteral nutrients secondary to insufficient intestinal length or function.
- Trial name
- NCT02721277
- Testing
- SMOFlipid
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Florida
General Anesthesia, Elective Surgery
Therapeutic Equivalence (TE) Study of Propofol 2% MCT Fresenius (MCT=Medium-Chain Triglycerides) Compared With Diprivan® in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate the therapeutic equivalence, based on pharmacodynamic parameters of Propofol 2% (20 mg/mL) MCT Fresenius and Diprivan® 20 mg/mL (AstraZeneca), administered by target controlled infusion…
- Trial name
- PropofolTE (NCT01856998)
- Testing
- Propofol, Diprivan
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fresenius Kabi
Ketosis, Epilepsy
Market Research - Acceptability Study for New MCT Fat Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children, young people and adults with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Fatty Acid Oxidation Disorder, Malabsorption
- Trial name
- NCT04309214
- Testing
- MCT fats
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Hypo-unawareness, Type 1 Diabetes Mellitus
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Insulin treatment often causes the blood glucose levels to fall too low (hypoglycemia). Hypoglycemia can be associated with confusion and disorientation as well as other symptoms such as palpitations, sweating and tremors.
- Trial name
- NCT01315171
- Testing
- Medium chain triglycerides
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Parkinson's Disease
Acute Effects of Medium Chain Triglyceride (MCT) Nutritional Ketosis on Parkinson's Disease (PD) Symptoms and Biomarkers (MCT-PD)
Background: The ketogenic diet uses fats as a person's major energy source rather than carbohydrates. There is increasing interest in using this diet to treat neurodegenerative disorders like Parkinson's disease.
- Trial name
- NCT04584346
- Testing
- Liquigen MCT oil, Standard American Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Inflammation, Cardiac Surgical Procedures
Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery
This study is a blinded, randomized, controlled prospective trial comparing immune response (sepsis, inflammatory response, pulmonary vasoconstriction) in 2 groups of infants less than 3-month old receiving pre and post…
- Trial name
- NCT00336908
- Testing
- a combination of MCT, LCT , and Fish Oil
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Inflammatory Response, Hepatic Function
Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function
Lipid emulsions are an essential part of parenteral nutrition, both as a part of energy supply, and as a source of essential fatty acids.
- Trial name
- NCT00600912
- Testing
- SMOFlipid®, 2-ClinOleic 20%®
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Klinikum Ludwigshafen
Pharmacokinetics
Ketone Levels Achieved After Medium Chain Triglyceride (MCT) Oil
Assessing Ketone levels achieved after varying doses of Medium Chain Triglyceride (MCT) oil
- Trial name
- NCT04389983
- Testing
- Medium Chain Triglyceride oil
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity Adult Onset, Lipid Metabolism Disorder
Improvement of Nutritional Status and Blood Lipid Profile by Using MCT Oil on Overweight and Obese Women
The purpose of this study is to examine whether MCT oil is effective in the change of blood lipid profile and body compositions on overweight or obese women aged 20-45.
- Trial name
- NCT04067323
- Testing
- Soya bean oil, MCT oil
- Where
- Vietnam
- Volunteers
- 161 people
- Sponsor
- National Institute of Nutrition, Vietnam
Prediabetic State
Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes
The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes.
- Trial name
- MCT+AE (NCT02678390)
- Testing
- MCT, MCT+ aerobic exercise, Aerobic exercise
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke