Clinical trials: Medium-chain Triglyceride
Epilepsy, Seizure
Medium Chain Triglycerides as an Adjunct to the Modified Atkins Diet for Women With Catamenial Epilepsy
The modified Atkins diet (MAD) has been shown to be effective in treating intractable epilepsy. Approximately 55% of the patients started on the diet are women of childbearing age and women with epilepsy often have a pattern of…
- Conditions
- Epilepsy, Seizure, Catamenial Epilepsy, Medically Resistant Epilepsy
- Trial name
- NCT02426047
- Testing
- betaquik®
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Healthy Adults
Comparing the Ketogenic Effect of Coconut Oil and Different MCTs
The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults.
- Trial name
- MCT-Coco (NCT02679222)
- Testing
- Coconut oil, Coconut oil + MCT, MCT
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Mild Cognitive Impairment
Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography)
A six month, placebo-controlled, parallel group project in which MCI participants will receive 30 g/day of a custom-made MCT-based ketogenic supplement or a matching placebo.
- Trial name
- BENEFIC (NCT02551419)
- Testing
- ketogenic drink
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Université de Sherbrooke
Candida Infection, Premature Infant
Effect of Medium Chain Triglyceride Intake on Colonization of Preterm Infants With Candida
This study evaluates whether adding a dietary supplement similar to coconut oil (MCT oil) to feedings in premature infants will reduce the amount of yeast (Candida) detectable in their stool.
- Trial name
- NCT03630770
- Testing
- Medium-Chain Triglyceride (MCT) Oil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Joseph Bliss
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis
MLCT Oil for Fatty Liver - PASS Trial
The main objective of this randomised pilot study is to explore the relative efficacy of dietary MLCT oil versus LCT oil (corn oil) in augmenting therapy of overweight and obese NAFLD patients with at least a 1-stage reversal…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, NAFLD
- Trial name
- PASS (NCT05217745)
- Testing
- MLCT Oil, LCT Oil (Corn Oil)
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National University Hospital, Singapore
Nervous System Disorder
Use of Betashot in Children and Adults With Epilepsy
In brief, this research is a prospective, feasibility study to evaluate the use of Betashot- a medium chain triglyceride- based (MCT) food for special medical purposes (FSMP) in children and adults diagnosed with epilepsy.
- Trial name
- NCT02825745
- Testing
- Betashot
- Where
- 2 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Vitaflo International, Ltd
Parkinson Disease
Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome
Parkinson's Disease (PD) is the second most common neurodegenerative disorder with common gut-related symptoms, which are attributed to alterations in the gut microbiome - the collection of microorganisms that live within the…
- Trial name
- KIM (NCT05469997)
- Testing
- Mediterranean-Ketogenic Diet, Mediterranean diet supplemented with medium-chain triglyceride oil
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of British Columbia
Ophthalmopathy
Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment
Background : Surgery is needed in order to flatten and position a detached retina onto the choroid, to allow sealing of the tears and to prevent or reverse vision loss.
- Trial name
- MCT (NCT03855462)
- Testing
- MCT oil injection
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Type 2 Diabetes
Medium Chain Triglycerides (MCT) and Whey Protein Isolate (WPI) for Type 2 Diabetes Patients (Combine)
Evaluation of effect on diurnal glycaemia following consumption of MCT and whey protein in patients with type 2 diabetes
- Trial name
- NCT04905589
- Testing
- BetaQuik™, WheyBasics, Iso-voluminous water
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Société des Produits Nestlé (SPN)
Ketonemia
Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants
Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
- Trial name
- Opti-MCT (NCT03830268)
- Testing
- No MCT intake with breakfast, no lunch, No MCT intake with lunch, no breakfast, 10g of Betaquik
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Metabolic Syndrome
Double-blind and Placebo-controlled Study on Intervention Effect of Medium and Long Chain Fatty Acid Triglyceride on Glycolipid Homeostasis in Patients With Metabolic Syndrome and Mechanisms
Double-blind and placebo-controlled study on intervention effect of medium and long chain fatty acid triglyceride on glycolipid homeostasis in patients with metabolic syndrome and mechanisms
- Trial name
- NCT06210230
- Testing
- MLCT supplementation, Olive oil
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Zhejiang University
Alzheimer's Disease, Primary Progressive Non-fluent Aphasia
A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease
The purpose of this study is to determine safety, tolerability, and pharmacokinetics/dynamics of a ketogenic dietary supplement containing medium chain triglycerides (MCTs) in patients with Alzheimer disease (AD).
- Conditions
- Alzheimer's Disease, Primary Progressive Non-fluent Aphasia, Frontotemporal Dementia (FTD)
- Trial name
- MINT-01 (NCT02912936)
- Testing
- Ketogenic medium chain triglyceride drink (MCT drink)
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of British Columbia
Healthy Adults
Evaluation of the Ketogenic Potential of Different Diet Supplements
Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.
- Trial name
- NCT02693106
- Testing
- Control, Leucine, Butyrate -
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
HIV Infections, HIV Wasting Syndrome
A Comparison of Two Caloric Supplements in the Prevention of Weight Loss in Patients With AIDS Who Take Daily Multivitamin and Mineral Supplements
To compare a caloric supplement containing peptides and medium-chain triglycerides, a caloric supplement containing whole protein and long-chain triglycerides, and no caloric supplement for the prevention of weight loss in…
- Trial name
- NCT00001077
- Testing
- Multivitamin and mineral supplements, Peptamen, NuBasics
- Where
- 17 sites in United States
- Volunteers
- 536 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Overweight
Effects of Medium Chain Triglyceride Oil, Versus Olive Oil, for Weight Loss
The primary aim of this research project is to determine whether the incorporation of food products containing medium chain triglyceride (MCT) oil in a weight-loss program results in a different degree of weight-loss and total…
- Trial name
- Muffin (NCT00529919)
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Medium Chain Triglycerides Plasma Profile and Their Metabolites After Oral Peptamen Intake
Medium Chain Triglycerides (MCT) have been used for many years as a good source of lipid to decrease potential for fat malabsorption.
- Trial name
- NCT02241681
- Testing
- Peptamen 1.5
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
People Who Are Overweight or Obesity
Effect of a Soluble Fibre Blend and Medium Chain Triglycerides on Body Composition and Cardiometabolic Risk Factors
The purpose of this study is to investigate whether the addition of capsules containing soluble fibre complex emulsified with medium chain triglycerides and taken before with meals will lead to a significant amount of weight…
- Trial name
- NCT00644098
- Testing
- soluble fibre complex and medium chain triglycerides, cellulose and soybean oil
- Where
- Canada
- Volunteers
- 138 people
- Sponsor
- Canadian Center for Functional Medicine
Metabolic Syndrome X
Effects of Medium-Chain Triglycerides on Chylomicron Secretion and Expression of Genes That Regulate Intestinal Lipid Metabolism in Men With Dyslipidemia Associated With the Metabolic Syndrome
Several lines of evidence indicate that a significant proportion of cardiovascular disease (CVD) events are attributable to the presence of a cluster of metabolic abnormalities and perturbations, defined as the metabolic…
- Trial name
- MCT (NCT01806142)
- Testing
- Medium-chain triglycerides, Corn oil
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Laval University
Bioavailability
Oxandrolone in Healthy Adults: A Relative Bioavailability Study
To assess the pharmacokinetics and relative bioavailability of a single dose of approximately 0.1 mg/kg of a medium chain triglyceride (MCT) oil oxandrolone solution vs. tablets in a small cohort of healthy adults.
- Trial name
- NCT03218631
- Testing
- Oxandrin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Utah
Thoracic Neoplasms
Post-operative Medium Chain Triglyceride Diet May Reduce Hospital Stay Following Lung Resection
Lung resection, a critical treatment for various thoracic diseases, including lung cancer, often necessitates prolonged hospitalization due to rare but severe postoperative complications such as chyle leaks, with an occurrence of…
- Trial name
- NCT07159659
- Testing
- MCT Diet
- Where
- Hong Kong
- Volunteers
- 210 people
- Sponsor
- Chinese University of Hong Kong