Clinical trials: Melancholic Depression
Crohn's Disease (CD), Ulcerative Colitis (UC)
Virtual Group Therapy for IBD Patients With Anxiety and Depression
This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety.
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety
- Trial name
- NCT07796568
- Testing
- Group Psychotherapy Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Anxiety Disorders, Depressive Symptoms
Collaborative Redesign of Implementation Strategies for the Brief Intervention for School Clinicians
Schools are the most common venue for youth mental health services, but school mental health (SMH) typically does not use evidence-based clinical interventions (CI), common elements of effective mental health, or effective…
- Conditions
- Anxiety Disorders, Depressive Symptoms, Mental Health Issue
- Trial name
- BRISC (NCT06968949)
- Testing
- Unadapted Brief Intervention for School Clinicians (BRISC; BR-O), Brief Intervention for School Clinicians (BRISC) with Implementation Strategies Adapted for School-Employed Practitioners (BR-A)
- Volunteers
- 60 people
- Sponsor
- University of Washington
Depression
Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes
The investigators will compare plasma kinetics of two marker drugs in individuals with different genetic variations in the MDR1-gene. The hypothesis is that one group will have higher exposure than the other.
- Trial name
- NCT01704638
- Testing
- fluvoxamine, Digoxin
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Bipolar Disorder
The Treatment of Children and Adolescents With Treatment-Resistant Depression
This study seeks to learn about brain function in adolescents with depression and to determine whether adding lithium carbonate to antidepressant medication can reduce depression in children and adolescents.
- Trial name
- NCT00029640
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Loneliness
Empower@Home:Connected - Feasibility and Preliminary Effect Study
This single-group trial will evaluate the feasibility and preliminary effect of a novel group-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Loneliness, Social Isolation, Depressive Disorder
- Trial name
- NCT05732740
- Testing
- Empower@Home:Connected
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
Depression, Neurocognitive Disorders
Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-
Depression in neurocognitive disorders (Alzheimers' disease and related disoders) is a highly prevalent condition, especially in nursing homes.
- Trial name
- PROTO-EHPAD (NCT06382389)
- Testing
- EMONO, Medical air
- Volunteers
- 96 people
- Sponsor
- University Hospital, Tours
Depression, Family Dynamics
The Mental Health Effects of a Mindfulness App in Parents of a Child With Medical Complexity
The number of children with special health care needs (CSHCN) in the US is nearly 20% of children representing approximately 14.6 million children nationally.
- Conditions
- Depression, Family Dynamics, Stress, Psychological, Chronic Illness
- Trial name
- NCT05925868
- Testing
- mindfulness app
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boise State University
Depression
Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly.
The trial aims to treat depression. The incidence of major depression in the elderly accounts for between 3.6 and 4.8% and increases to 8 to 37.4% when depressive disorders in general is studied.
- Trial name
- NCT02793648
- Testing
- Ascorbic Acid, Alpha tocopherol
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Yolanda de Diego Otero
Fibromyalgia, Covid-19 Fear
The Effects of Covid-19 Pandemic on The Patients With Fibromyalgia
The investigators planned to analyze the effect of Covid-19 fear and anxiety on the daily life, sleep quality and depression-anxiety levels of fibromyalgia patients.
- Conditions
- Fibromyalgia, Covid-19 Fear, Covid-19 Anxiety, Daily Life
- Trial name
- NCT04686578
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Psychological Stress, Sleep Disturbance
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in…
- Conditions
- Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms
- Trial name
- NM90 (NCT07717385)
- Testing
- Neuralli Mood
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Depression; Bipolar Disorder
Comparing Different Patterns of rTMS in Major Depression
This trial will compare the trajectories of improvement for three different patterns of twice-daily rTMS in major depression: two daily sessions of dorsomedial prefrontal rTMS delivered at 0 min vs. 30 min vs. 60 min intervals.
- Trial name
- NCT02778035
- Testing
- Dorsomedial prefrontal rTMS
- Where
- 2 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University Health Network, Toronto
Postpartum Hemorrhage, Postpartum Women
Prevalence of Psychological Disorders After Immediate Postpartum Hemorrhage
The objective of this cross-sectional study is to assess the prevalence of depression at 2 months, 6 months, and 1 year postpartum in women who had an immediate postpartum hemorrhage (immediate PPH defined as blood loss ≥ 500 mL…
- Conditions
- Postpartum Hemorrhage, Postpartum Women, Postpartum Depression, Postpartum Stress
- Trial name
- PSYCHE (NCT03120208)
- Testing
- • The Edinburgh postnatal depression scale (EPDS), validated in French, with a discrimination threshold ≥ 11., The GAD-7 with a discrimination threshold ≥10., • Spielberger's State-Trait anxiety inventory, Form Y (validated in French), with a STAI (form Y-A) discrimination threshold ≥ 46
- Where
- France
- Volunteers
- 1,298 people
- Sponsor
- University Hospital, Clermont-Ferrand
Bipolar Disorder
Acute Treatment of Bipolar II Depression
This study will compare the medications lithium and lamotrigine (Lamictal®) in treating depression in individuals with bipolar II disorder.
- Trial name
- NCT00074776
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Stanford University
Intervention, Waitlist Control
Qigong and Executive Attention in Older Adults with Depressive Symptoms
The goal of this randomized controlled trial is to test whether executive attention unpacks the antidepressant effect of Baduanjin (a form of health qigong) in older adults.
- Trial name
- NCT06852417
- Testing
- Health qigong training
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression, OCD
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
The study involves multiple retrospective analyses to understand the utilization of mental health treatments provided at Greenbrook and their effectiveness
- Conditions
- Depression, OCD, Anxiety Depression
- Trial name
- NCT06997549
- Testing
- Patients treated with NeuroStar TMS, Patients treated with Esketamine
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- Neuronetics
Opioid Use Disorder, Depressive Disorder
Ketamine for OUD and Comorbid Depression (OUDCD)
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge.
- Trial name
- NCT05051449
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Ischemic Heart Disease (IHD), Anxiety
Online Personalized Psychological Intervention for Patients With Heart Disease and Depression or Anxiety (MY-CHOICE)
The goal of this feasibility study is to assess if the personalised online psychological intervention MY-CHOICE is acceptable to adults with ischemic heart disease and anxiety or depression.
- Conditions
- Ischemic Heart Disease (IHD), Anxiety, Depression
- Trial name
- MY-CHOICE (NCT07569458)
- Testing
- Online psychological therapy
- Where
- 3 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Anxiety, Depression
The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms
The goal of this study is to determine if a developed protocol involving modulated auditory stimulation is better than non-modulated auditory stimulation in reducing anxiety and depression in human subjects.
- Trial name
- SSP (NCT06701578)
- Testing
- Safe and Sound Protocol, Control
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- HealthPartners Institute
Mental Health Care, Mental Disorders
Using Responsible Artificial Intelligence (AI) to Predict Online Therapy Outcome and Engagement
This study is to develop AI-based models for the personalised prediction of treatment engagement and treatment outcomes in patients engaging in digital psychotherapy.
- Trial name
- NCT05758285
- Testing
- AI-Based Prediction of Treatment Engagement and Outcomes
- Where
- Switzerland
- Volunteers
- 6,671 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Uncertain Viability of Pregnancy, Anxiety
Psychological Impact of Predicting Early Pregnancy Outcomes in Women With Pregnancy of Uncertain Viability
This study will evaluate if providing women diagnosed with an intrauterine pregnancy of uncertain viability with a percentage likelihood of ongoing viability of their pregnancy at the time of the follow-up ultrasound, will result…
- Conditions
- Uncertain Viability of Pregnancy, Anxiety, Depression
- Trial name
- IMPROVE (NCT03264170)
- Testing
- Prediction of pregnancy outcome
- Volunteers
- 250 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust