Clinical trials: Melanosis
Melasma
Oral Superoxide Dismutase (GLISODin) to Decrease Melasma Severity.
Oxidative stress has been reported to play a role in melasma pathophysiology. The objective of the study is to compare oral superoxide dismutase (GLISODin) to placebo, in combination to sunscreen to decrease melasma severity.
- Trial name
- Glisodin (NCT03878433)
- Testing
- Glisodin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melasma
Treatment of Melasma With Glycolic Acid-Salicylic Acid Peel Versus Glycolic Acid Peel
The aim of this pilot study is to conduct a controlled comparison of the efficacy and safety of a combination peel (glycolic acid and salicylic acid) as compared to glycolic acid peel alone in the treatment of melasma.
- Trial name
- NCT02812719
- Testing
- Glycolic acid peel alone, Glycolic and salicylic acid peel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Medical Center
Melanosis
A Pilot Study Testing Salicylic Acid Peels Versus Glycolic Acid Peels for the Treatment of Melasma
The purpose of this study is to find out the safety and effectiveness of Glycolic Acid Chemical Peels compared to Salicylic Acid Chemical Peels for the treatment of melasma.
- Trial name
- NCT01976286
- Testing
- Salicylic Acid Peels, Glycolic Acid Peels
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Melanosis
Azelaic Acid Versus Hydroquinone in Melasma
The purpose of this study is to compare the safety and effectiveness of Azelaic Acid Gel to Hydroquinone Cream in the treatment of melasma.
- Trial name
- NCT00927771
- Testing
- azelaic acid gel, hydroquinone cream
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Callender Center for Clinical Research
Melasma
A Study of the RevLite Laser System for the Treatment of Refractory Mixed Type Melasma
The purpose of this study is to compare a hydroquinone skin care regimen alone to a combination of Revlite Laser treatment with a hydroquinone skin care regimen for the treatment of melasma.
- Trial name
- NCT02110134
- Testing
- Revlite Laser System with hydroquinone skin care regimen, Hydroquinone skin care regimen
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Cynosure, Inc.
Melasma
Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) could serve as a novel cell-free…
- Trial name
- NCT06221787
- Testing
- 1565 nm non-ablative fractional laser combined with normal saline, microneedles combined with hUCMSC-Exos, 1565 nm non-ablative fractional laser combined with hUCMSC-Exos
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University Union Hospital
Melasma
Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma
Evaluate atrophogenic potential of long-term use of Tri-Luma Cream on facial Melasma through biopsy examination.
- Trial name
- NCT00469183
- Testing
- Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05%
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Solar Lentigines
A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy
To evaluate safety and efficacy of Tri-Luma® cream as an adjunctive treatment to cryotherapy when used in the pre- and post-procedure phases for the treatment of solar lentigines on the back of the hands and in the prevention of…
- Trial name
- NCT01778179
- Testing
- Tri-luma, Cryotherapy (CRY-AC3® device)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Melasma
Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.
This study would offer the participants about the knowledge of these formula in the treatment of melasma and help the investigators in incorporating and updating the management protocols in medical practice.
- Trial name
- NCT06013540
- Testing
- TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C), Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)
- Where
- Pakistan
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Melanosis
Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma
Kligman's trio remains the gold standard treatment for melasma. It contain hydroquinone which is an effective anti-melanogenic compound but that has poor tolerance and numerous side-effects.
- Trial name
- Kligman (NCT05119413)
- Testing
- New trio de Kligman, Trio Kligman
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Familial Ovarian Cancer, Familial Breast Cancer
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Individuals and families with known or suspected syndromes that include breast, ovarian or genetically-related cancers are enrolled in this family study, which is a syndrome-specific sub-set of the long-standing DCEG Human…
- Conditions
- Familial Ovarian Cancer, Familial Breast Cancer, BRCA1-associate Malignancies, BRCA2-associated Malignancies
- Trial name
- NCT00040222
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- National Cancer Institute (NCI)
Acanthosis Nigricans
Evaluating the Safety and Efficacy of Topical Sirolimus 0.2% to Treat Acanthosis Nigricans
The purpose of this study is to demonstrate the safety and efficacy of Sirolimus 0.2% topical gel for patients with Acanthosis Nigricans
- Trial name
- NCT06940895
- Testing
- Sirolimus 0.2%
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Narrows Institute for Biomedical Research
Actinic Keratosis
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Actinic Keratoses
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of actinic keratoses.
- Trial name
- NCT00107965
- Testing
- PEP005
- Where
- 6 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Peplin
Melasma
Comparison of Chemical Peeling Agent With Transamine for Treatment of Melasma
Melasma is an acquired skin disorder characterized by hyper-melanosis. Melasma is a term that originates from the Greek root "melas" (black color) and was formerly known as chloasma.
- Trial name
- NCT05362500
- Testing
- Glycolic Acid 70%, Tranexamic acid injection
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
The Efficacy in Treatment of Facial Melasma Combined With Thulium 1927-nm Fractional Laser and Topical H2R Antagonist
Melasma is a hyperpigmentary disorder of the skin especially of the face. Compared with normal skin, histologic features of melasma include the enhanced activity of melanocytes, higher solar elastosis in upper dermis, basement…
- Trial name
- NCT06313307
- Testing
- topical H2R antagonist, Thulium 1927-nm Fractional Laser
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Melasma
Melanil in the Treatment of Melasma
The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks.
- Trial name
- NCT01001624
- Testing
- Melanil facial cream, Hydroquinone 2% cream
- Where
- Cuba
- Volunteers
- 150 people
- Sponsor
- Catalysis SL
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06320314
- Testing
- tested product (2039125 03)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Pancreatic Cancer, Pancreas Cancer
Pancreatic Cancer Early Detection Program
Early detection testing is recommended for individuals at elevated risk for the development of Pancreatic Cancer. This Protocol will define sufficiently elevated risk as either equal to or greater than five times the general…
- Conditions
- Pancreatic Cancer, Pancreas Cancer, Pancreatic Adenocarcinoma, Familial Pancreatic Cancer
- Trial name
- PCEDP (NCT02206360)
- Testing
- Endoscopic Ultrasound, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- White Plains Hospital
Melasma
Treatment of Melasma Using Q-switched Nd: YAG Laser and Fractional CO2 Laser Separately and in Combination
All participants will be divided into 2 groups : Group A \& Group B. Group A will be subjected to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face \& fractional co2 laser to the other side of…
- Trial name
- NCT03848013
- Testing
- Q switched Nd YAG laser, Fractional CO2 laser
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Melasma
Treatment and Prevention of Melasma Relapses by Using 1064nm 650 Microsecond Laser
Melasma is a frequently acquired hyperpigmentary disorder affecting up to 30% of child-bearing women in some populations. Melasma is still often called chloasma or the pregnancy mask and is considered as the main consequence of…
- Trial name
- Melasma650 (NCT06644157)
- Testing
- Laser Néo Élite
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice