Clinical trials: Melasma
Melasma, Treatment Outcome
Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma
This study compares the effectiveness of two oral medications-melatonin and tranexamic acid -in treating melasma, a common skin condition that causes dark facial patches.
- Conditions
- Melasma, Treatment Outcome, Recurrence
- Trial name
- TXA-MELA (NCT07034560)
- Testing
- Tranexamic Acid (TXA), melatonin (Circadin)
- Where
- Thailand
- Volunteers
- 75 people
- Sponsor
- Thammasat University
Melasma
1064-nm Q-switched Nd:YAG Laser and Intradermal Tranexamic Acid for Melasma
BACKGROUND: Melasma is a chronic, often relapsing skin disorder, with poor long-term results from all current therapies.Q switched 1064nm Nd:YAG laser and intradermal tranexamic acid both showed efficacy on the treatment of…
- Trial name
- NCT03008655
- Testing
- intradermal tranexamic acid, Nd-YAG
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Melasma
Tissue-resident Memory T Cells Expression in Melasma
The treatment of melasma and the maintenance of depigmentation represent a challenge due to its frequent recurrences. Pathophysiological mechanisms and factors have been linked to melasma such as inflammation, sun exposure…
- Trial name
- NCT05698342
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma
Evaluation of Laser and Tranexamic Acid in Treatment of Melasma
Melasma Is an acquired, chronic, recurrent, symmetrical hypermelanosis, which is characterized by brown patches of variable darkness on sun exposed areas of the body. It is more common in women.
- Trial name
- NCT04599205
- Testing
- Tranexamic acid
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Melasma
Opsin Receptors in Melasma
Melasma is a hyperpigmentation disorder that is probably exacerbated by visible light. Opsin receptors (OPN 1, 2, 3, 4 y 5) were described in the skin, being capable of activating melanogenesis induced by visible light.
- Trial name
- NCT04417348
- Testing
- Retinoic acid
- Where
- Mexico
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma
A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma
This is a single centre, 2-cell, single blinded full-face (products applied at lesional sites) study to evaluate changes in melasma through a cosmetic facial serum formulation and marketed 2% Hydroquinone product
- Trial name
- NCT05013801
- Testing
- Cosmetic facial serum Q69, 2% Hydroquinone
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Melasma
DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.
BACKGROUND: Malar melasma has a chronic and recurrent character that may be related with epigenetic changes.
- Trial name
- NCT03392623
- Testing
- Retinoic acid, colorimetry measurement, sunscreen
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Melasma
Comparison of Intradermal Microinjections of Tanexamic Acid and Oral Tranexamic Acid in the Management of Melasma.
In this study we compared the effect of intradermal microinjections of tranexamic acid vs oral tranexamic acid in treatment of melasma.
- Trial name
- NCT07280234
- Testing
- Intradermal microinjections of tranexamic acid, Oral tranexamic acid
- Where
- Pakistan
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Hayat Abad Medical Complex, Peshawar
Melasma
Cysteamine Compared to Hydroquinone in Melasma
Melasma is an acquired pigmentary disorder of symmetrical hyperpigmentation appearing as variable darkness macules and patches over the forehead, cheeks, and chin, even sun-exposed areas of the body.
- Trial name
- NCT05969587
- Testing
- 5% cysteamine cream, hydroquinone cream group
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Melasma
Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma
The objective of this study is evaluating the clinical activity of the association (tretinoin + arbutin + triamcinolone) in the treatment of epidermal melasma.
- Trial name
- melasma (NCT00717652)
- Testing
- arbutin, tretinoin, triamcinolone, Triluma
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Azidus Brasil
Melasma
Oral Polypodium Leucotomos for Melasma
Primary Objective: To determine whether there is improvement in the melasma of participants taking oral Polypodium Leucotomos Secondary Objective: To determine whether oral Polypodium Leucotomos is well tolerated in study…
- Trial name
- NCT01162850
- Testing
- Polypodium Leucotomos
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Miami
Facial Melasma
Efficacy and Safety of a 4% Hydroquinone Cream for the Treatment of Melasma
To assess the ability of a new 4% Hydroquinone formulation (Melanoderm 4% Crema) to reduce melasma on the face, using a split-face randomization design, evaluating the MASI Score from baseline to week 4 and week 8, in both…
- Trial name
- NCT02095990
- Testing
- Hydroquinone
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- Mesoestetic Pharma Group S.L.
Melasma
Oral Metformin for Treating Melasma in Latin American Women
The goal of this clinical trial is to learn if metformin can treat melasma in Latin American women. The main question it aims to answer is: Can metformin help reduce the dark patches of melasma? Researchers will test two…
- Trial name
- NCT06845540
- Testing
- Metformin
- Where
- Puerto Rico
- Volunteers
- 30 people
- Sponsor
- University of Puerto Rico
Melasma
Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma
In this study, the investigators evaluate the potential efficacy of TXA alone and microneedling assisted with glutathione alone versus combination of oral tranexamic acid and glutathione-assisted microneedling in the treatment of…
- Trial name
- NCT07448415
- Testing
- microneedling, Oral tranexamic acid, Glutathione
- Volunteers
- 42 people
- Sponsor
- Assiut University
Melasma, Melasma (Facial Melasma)
Randomized Split-Face Controlled Study to Evaluate the Effectiveness of Topical Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% as Compared to Topical Tretinoin 0.05% + Hydroquinone 4% + Fluocinolone 0.01% for the Treatment of Melasma
The purpose of this study is to find out whether a new combination cream containing eflornithine, hydroquinone, and fluocinolone works better and causes fewer side effects than Tri-Luma® (tretinoin, hydroquinone, and…
- Trial name
- NCT07876323
- Testing
- Eflornithine 9.58% + Hydroquinone 4% + Fluocinolone 0.01% cream, Tretinoin 0.05% + hydroquinone 4% + fluocinolone 0.01% cream
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National Skin Centre
Melasma
Study of Acid Peel and Laser for the Treatment of Melasma
The objective of this study is to evaluate laser treatment and acid peel for the treatment of melasma.
- Trial name
- NCT00467233
- Testing
- Laser Treatment, Acid Peel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwestern University
Chloasma
Identification of Biomarkers and Characterization of Melasma
Melasma (also called chloasma and pregnancy mask) is characterized by pigmented lesions darker than their usual complexion on the faces of affected subjects. The physiopathology of melasma is still poorly understood.
- Trial name
- NCT03618277
- Testing
- Biopsy
- Sponsor
- Pierre Fabre Dermo Cosmetique
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06234527
- Testing
- tested product
- Where
- Senegal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Silymarin Cream Versus Combined Silymarin Cream and Microneedling in Treatment of Melasma
Melasma is an acquired pigmentary disorder, occurring most commonly on the face. It is more prevalent in females and darker skin types.
- Trial name
- NCT05099601
- Testing
- Silymarin, Microneedling
- Volunteers
- 30 people
- Sponsor
- Assiut University
Melasma
Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma
The objective of this study is to evaluate the efficacy and tolerability of Lytera 2.0 versus 4% hydroquinone in the improvement of the appearance of moderate facial melasma.
- Trial name
- NCT02977507
- Testing
- Lytera 2.0, 4% Hydroquinone Topical Cream, SkinMedica Facial Cleanser
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Allergan