Clinical trials: Melasma
Melasma
Study Evaluating the Efficacy of DOSE Formulations in Treating Melasma and Cutaneous Signs of Aging
The primary objective is to evaluate the efficacy, of D.O.S.E formulations in the treatment of melasma and cutaneous signs of aging.
- Trial name
- NCT04137263
- Testing
- DOSE formulation
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Melasma
Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma
This study assess the effectiveness of oral tranexamic acid in combination with hydroquinone cream in the treatment of melasma.
- Trial name
- NCT03751163
- Testing
- Tranexamic Acid Oral Product, Hydroquinone 4% Cream, Sunscreen
- Volunteers
- 50 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Pigmentation, Pigmentation Disorder
Effects of RF Microneedle on Photoaging Skin
Melasma relapse is almost common after discontinuation of conventional treatment. Recent studies have suggested that photoaging dermis is main pathomechanism of melasma emphasizing stromal targeting therapy.
- Trial name
- NCT05710068
- Testing
- RF Microneedle, Combination cream
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Ajou University School of Medicine
Melasma
Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma
This interventional, randomized, investigator blinded, controlled study conducted in one centre consists in a 4-month evaluation period within the same season avoiding sunny season on 140 subjects with facial epidermal melasma.
- Trial name
- NCT06278948
- Testing
- Group TP, Group CYS
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melanosis
Comparison of a New Masterful Preparation to Kligman's Trio in the Treatment of Melasma
Kligman's trio remains the gold standard treatment for melasma. It contain hydroquinone which is an effective anti-melanogenic compound but that has poor tolerance and numerous side-effects.
- Trial name
- Kligman (NCT05119413)
- Testing
- New trio de Kligman, Trio Kligman
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melasma
Comparative Efficacy of Intralesional Tranexamic Acid Versus Mandelic Acid Peel in the Treatment of Melasma
Melasma is a chronic acquired disorder of facial hyperpigmentation that significantly affects quality of life. Both intralesional tranexamic acid and mandelic acid chemical peels are effective treatment options with favorable…
- Trial name
- NCT07604844
- Testing
- Mandelic Acid Peel, Intralesional Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
Fractional Photothermolysis for Treating Melasma
In several observational studies, non-ablative fractional photothermolysis (FP) has been reported to bridge the gap between efficacy and tolerability in the treatment of melasma.
- Trial name
- NCT01245881
- Testing
- Non-ablative fractional photothermolysis laser, broad-spectrum sunblock (SPF 50+)
- Where
- Germany
- Volunteers
- 51 people
- Sponsor
- Laserklinik Karlsruhe
Melasma
Comparison of 30% Metformin and 2% Nicotinamide Lotion With Kligman Formula in the Treatment of Melasma
Comparison of 30% Metformin and 2% Nicotinamide lotion with kligman formula in the treatment of Melasma
- Trial name
- NCT05790577
- Testing
- Metformin and Nicotinamide vs Kligman Formula
- Where
- Pakistan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ishtiaq Ahmed
Melasma
Treatment of Melasma Using Q-switched Nd: YAG Laser and Fractional CO2 Laser Separately and in Combination
All participants will be divided into 2 groups : Group A \& Group B. Group A will be subjected to 3 consecutive sessions of Q-switched 1,064 nm Nd: YAG laser to one side of the face \& fractional co2 laser to the other side of…
- Trial name
- NCT03848013
- Testing
- Q switched Nd YAG laser, Fractional CO2 laser
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Melasma
Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.
This study would offer the participants about the knowledge of these formula in the treatment of melasma and help the investigators in incorporating and updating the management protocols in medical practice.
- Trial name
- NCT06013540
- Testing
- TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C), Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)
- Where
- Pakistan
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Cryotherapy Effect
A Cryotherapy With Tranexamic Acid Versus Normal Saline in the Treatment of Melasma
This study aimed to evaluate the effectiveness of a precision cryotherapy via boosting mode combined with tranexamic acid versus normal saline in the treatment of melasma.
- Trial name
- NCT06491771
- Testing
- TargetCool
- Where
- Thailand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Melasma
Cysteamine Compared to Hydroquinone in Melasma
Melasma is an acquired pigmentary disorder of symmetrical hyperpigmentation appearing as variable darkness macules and patches over the forehead, cheeks, and chin, even sun-exposed areas of the body.
- Trial name
- NCT05969587
- Testing
- 5% cysteamine cream, hydroquinone cream group
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Melasma
Tri-split Face Study of Skin Resurfacing Modalities for the Treatment of Melasma
Tri-split face study of skin resurfacing modalities for the treatment of melasma, comparing the medium depth trichloroacetic acid peel, CO2 laser and Qs-NdYag laser.
- Trial name
- NCT02892071
- Testing
- 22% TCA peel, CO2 laser, Qs-NdYag laser
- Volunteers
- healthy volunteers welcome
- Sponsor
- SUZAN OBAGI
Melasma
Split-face Study Comparing the Cosmetic Efficacy and Tolerability of Two Topical Products in Participants With Moderate Facial Melasma
The objective of this study is to evaluate the efficacy and tolerability of Lytera 2.0 versus 4% hydroquinone in the improvement of the appearance of moderate facial melasma.
- Trial name
- NCT02977507
- Testing
- Lytera 2.0, 4% Hydroquinone Topical Cream, SkinMedica Facial Cleanser
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Allergan
Melasma
Oral Superoxide Dismutase (GLISODin) to Decrease Melasma Severity.
Oxidative stress has been reported to play a role in melasma pathophysiology. The objective of the study is to compare oral superoxide dismutase (GLISODin) to placebo, in combination to sunscreen to decrease melasma severity.
- Trial name
- Glisodin (NCT03878433)
- Testing
- Glisodin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Melasma
Salicylic Acid Peels Combined With 4% Hydroquinone in the Treatment of Moderate to Severe Melasma in Hispanic Women
This study will enroll 20 adult Hispanic women. Participants will apply 4% hydroquinone cream twice daily to affected areas on the face for 14 weeks and half the face will be peeled with 20-30% salicylic acid every two weeks for…
- Trial name
- NCT00616239
- Testing
- 20-30% Salicylic Acid peels to the right side of the face, 20-30% Salicylic Acid peels to the left side of the face
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Melasma
Efficacy of Melanostop Peeling for Improvement of Melasma
Participants with face melasma will receive 4 Melanostop peel treatments containing 20% azelaic acid, 10% resorcinol and 6% phytic acid. Peels will be performed at 2-week interval.
- Trial name
- VIMEL (NCT03826277)
- Testing
- Melanostop peel
- Where
- Slovenia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Melasma
Tranexamic Acid With Microneedling in Melasma
Topical tranexamic, a hydrophilic molecule, can't pass the lipid barriers of the stratum corneum and it's also not retained in adequate amount in the epidermis to enter the melanocytes, so there's a difficulty in the effective…
- Trial name
- NCT05909072
- Testing
- Hyaluronic acid combined with tranexamic acid microneedling, tranexamic acid microneedling
- Volunteers
- 27 people
- Sponsor
- Zagazig University
Epidermal Melasma, Facial Hyperpigmentation
Topical Metformin Versus Triple Regimen for Epidermal Melasma
Melasma is a common skin condition that causes dark brown patches, mainly on sun-exposed areas of the face. It is often persistent, may recur after treatment, and can affect a person's quality of life.
- Trial name
- MET-MEL (NCT07779811)
- Testing
- Topical 30% metformin cream, Topical Triple Regimen
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Combined Military Hospital, Pakistan
Melasma
Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
This is a prospective, multi-center, split-face, controlled clinical trial that aims to investigate the efficacy and safety of picosecond, neodymium-doped yttrium aluminum garnet laser laser therapy on patients with melasma…
- Trial name
- NCT03040089
- Testing
- PICO+4, Neoquine Cream 2%
- Volunteers
- 40 people
- Sponsor
- CynosureLutronic