Clinical trials: Melasma (Facial Melasma)
Melasma
Efficacy and Safety of Picosecond, Neodymium-doped Yttrium Aluminum Garnet Laser Therapy Using 1,064 nm and 595 nm
This is a prospective, multi-center, split-face, controlled clinical trial that aims to investigate the efficacy and safety of picosecond, neodymium-doped yttrium aluminum garnet laser laser therapy on patients with melasma…
- Trial name
- NCT03040089
- Testing
- PICO+4, Neoquine Cream 2%
- Volunteers
- 40 people
- Sponsor
- CynosureLutronic
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06268496
- Testing
- serum formula 2039125 03
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Facial Hyperpigmentation
Open-label, Single-arm, Proof of Concept Study in Subjects with Mild-to-moderate Facial Hyperpigmentation
This research study will test how well hyperpigmentation treatment works for subjects with mild-to-moderate facial hyperpigmentation. The study will also test if the hyperpigmentation treatment causes any irritation.
- Trial name
- K-BRIGHT (NCT06473974)
- Testing
- Test cosmetic product
- Where
- 2 sites in United States
- Sponsor
- Kayuraeffect, LLP
Facial Melasma
Efficacy and Safety of a 4% Hydroquinone Cream for the Treatment of Melasma
To assess the ability of a new 4% Hydroquinone formulation (Melanoderm 4% Crema) to reduce melasma on the face, using a split-face randomization design, evaluating the MASI Score from baseline to week 4 and week 8, in both…
- Trial name
- NCT02095990
- Testing
- Hydroquinone
- Where
- Spain
- Volunteers
- 17 people
- Sponsor
- Mesoestetic Pharma Group S.L.
Hyperpigmentation
Efficacy and Tolerability of the Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06234527
- Testing
- tested product
- Where
- Senegal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma
The objective of this study is evaluating the clinical activity of the association (tretinoin + arbutin + triamcinolone) in the treatment of epidermal melasma.
- Trial name
- melasma (NCT00717652)
- Testing
- arbutin, tretinoin, triamcinolone, Triluma
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Azidus Brasil
Hyperpigmentation, Melasma
A 4-week Study Investigating Two Targeted Brightening Serum (A and B) Versus 4% Hydroquinone in Women With Mild to Severe Full-face Hyperpigmentation
This a short four-week pilot study to measure the efficacy and tolerance of two brightening serums (cosmetics) versus 4% hydroquinone. The study was conducted in two sites across the USA, one in PA and in one in CA.
- Conditions
- Hyperpigmentation, Melasma, Dark Spots
- Trial name
- NCT07644871
- Testing
- Facial Cleanser, Facial Moisturizer, Sunscreen SPF 55
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Melasma
Efficacy and Safety of PiQo4 Device for Treatment of Melasma
Single center, Prospective, Open Label with Split-face Study Design. Face sides will be randomized to receive either 1064nm alone or 1064nm \& 585nm combination treatment.
- Trial name
- NCT03565341
- Testing
- PiQo4
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Focus Medical, LLC
Healthy
A Study to Assess Effect of Two Facial Sunscreens in Improving Wrinkles, Fine Lines and Melasma in Adult Participants
The purpose of this study is to evaluate the topical safety (tolerability/acceptability) and efficacy of two facial sunscreen in improving wrinkles, fine lines and melasma after 84 +/- 2 days of use under normal conditions on the…
- Trial name
- NCT05864417
- Testing
- Sunscreen Color tone 2.0, Sunscreen Color tone 3.0
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Melasma
EFFICACY and TOLERABILITY of TESTED FORMULA VS. HYDROQUINONE 4% in the TREATMENT of FACIAL MELASMA
This study aims at assessing the non-inferiority of tested formula facial serum (2039125 03) versus hydroquinone 4% over 3 months for treatment and then 3 months for maintenance ofwomen subjects presenting facial melasma.
- Trial name
- NCT06787846
- Testing
- Experimental: Group TP, Active Comparator: Group HQ: Hydroquinone 4%
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Combination Alexandrite Laser and Topical Therapy vs Topical Therapy Alone for Treatment of Melasma
The purpose of this study is to evaluate the efficacy and safety of a combination of non-hydroquinone topical therapy and a 755nm Alexandrite compared to topical therapy alone for the treatment of facial melasma.
- Trial name
- NCT02095756
- Testing
- 755nm Alexandrite Laser and Lytera Skin Brightening System (Non-Hydroquinone Topical Therapy), Lytera Skin Brightening System (Non-hydroquinone topical therapy)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cynosure, Inc.
Hyperpigmentation, Melasma (Facial Melasma)
Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation
This is a single-center, single-blind clinical study designed to evaluate the efficacy of a depigmenting gel cream through clinical, subjective, and instrumental assessments.
- Trial name
- HYPERPIG (NCT07769268)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06253468
- Testing
- tested product
- Where
- Singapore
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Melasma
Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma
This study is to evaluate the efficacy and safety of Tri-Luma® Cream (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) when used sequentially with a series of intense pulsed light (IPL) treatments in Subjects…
- Trial name
- NCT00669071
- Testing
- Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%, Cetaphil® Moisturizing Cream as Inactive Control
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- Galderma R&D
Melasma
Anti-pigmenting Effect of a Routine of Facial Products in Subjects With Melasma
This 6 month, comparative study assesses the benefit of a dermocosmetic regimen (Serum B3 + B3 retinol night cream) for 6 months compared to hydroquinone 4% (the gold standard in hyperpigmentation) followed by the dermocosmetic…
- Trial name
- NCT06516224
- Testing
- Liftactiv® B3 Serum, Liftactiv® B3 retinol night cream, Sunscreen UVAage® Inter SPF 50+
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Melasma
A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma
This is a single centre, 2-cell, single blinded full-face (products applied at lesional sites) study to evaluate changes in melasma through a cosmetic facial serum formulation and marketed 2% Hydroquinone product
- Trial name
- NCT05013801
- Testing
- Cosmetic facial serum Q69, 2% Hydroquinone
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Melasma
Melanil in the Treatment of Melasma
The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks.
- Trial name
- NCT01001624
- Testing
- Melanil facial cream, Hydroquinone 2% cream
- Where
- Cuba
- Volunteers
- 150 people
- Sponsor
- Catalysis SL
Hyperpigmentation
Efficacy and Tolerability of Tested Formula After 3 Months in Treatment of Facial Hyperpigmentation of 3 Origins
The objective of this study is to evaluate the efficacy, cosmetic acceptability and improvement of the stigmatization of the tested product (2039125 03) used bis in die (BID) for 3 months in adult patients suffering from mild to…
- Trial name
- NCT06320314
- Testing
- tested product (2039125 03)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International