Clinical trials: Melasma (Facial Melasma), open to volunteers
Melasma (Facial Melasma)
Oral Melatonin Versus Oral Tranexamic Acid in the Management of Melasma
This study will compare the efficacy of oral melatonin and oral tranexamic acid in treating melasma, with the aim of determining whether melatonin is more effective than tranexamic acid, as measured by MASI scores.
- Trial name
- Melasma (NCT07169383)
- Testing
- Melatonin tablet, Tranexamic Acid (TXA)
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Hina Malik
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Melasma, Melasma (Facial Melasma)
Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study
This study aims to gather expert opinions on the best ways to treat and manage melasma, a common skin condition characterized by dark patches on the face.
- Trial name
- NCT07296549
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Venus Research Center
Melasma (Facial Melasma)
Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma
Melasma is a common skin condition characterized by brown or gray patches on sun-exposed areas of the face. Although several topical treatments are available, treatment outcomes are often unsatisfactory, and recurrence is common.
- Trial name
- NCT07696806
- Testing
- Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sameh Sarsik
Post-inflammatory Hyperpigmentation, Melasma
A Clinical Study to Evaluate the Efficacy in Improving Dark Spots After 8 Weeks of Use of Facial Sunscreens in Adult Participants
The study aims to evaluate the efficacy of a facial sunscreen under two experimental conditions-untinted and tinted-in improving facial spots (melasma and solar lentigines/post-inflammatory hyperpigmentation) after 8 weeks of…
- Conditions
- Post-inflammatory Hyperpigmentation, Melasma, Solar Lentigo
- Trial name
- El Porto Ex-US (NCT07679945)
- Testing
- Sunscreen untinted, Sunscreen tinted
- Where
- Brazil
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Melasma
Topical Metformin Versus Topical Ketotifen in Melasma Treatment
The study aims to evaluate and compare the efficacy and safety of a new formulation of topical metformin (nanoparticles) versus topical ketotifen (nanoparticles), both alone and combined with micro-needling, for the treatment of…
- Trial name
- NCT06942390
- Testing
- Micro-Needling Combined with ketofin and metformin, ketofin and metformin Alone
- Volunteers
- 60 people
- Sponsor
- Assiut University
Melasma (Facial Melasma)
Ultrasound-Enhanced Delivery of Compound TXA Solution in Melasma
Melasma is a localized, acquired hyperpigmentary skin disorder characterized by well-defined, light to dark brown patches. Based on clinical practice and extensive literature reports, tranexamic acid and reduced Glutathione (GSH)…
- Trial name
- NCT07202156
- Testing
- 10%TXA+2%Reduced Glutathione applied via ultrasound at 5W/cm² in10min, 10%TXA+2%Reduced Glutathione applied via ultrasound at 0W/cm² 10min
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Melasma
Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma
Melasma is a common, long-lasting pigmentation disorder of the face. Some patients improve well with treatment and others improve little, and there is no simple way to predict this at the first visit.
- Trial name
- NCT07881328
- Testing
- Tranexamic acid, Standardised sunscreen and emollient
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Allied Hospital Faisalabad
Hyperpigmentation, Melasma (Facial Melasma)
Efficacy Evaluation of a Cosmetic Product for Facial Hyperpigmentation
This is a single-center, single-blind clinical study designed to evaluate the efficacy of a depigmenting gel cream through clinical, subjective, and instrumental assessments.
- Trial name
- HYPERPIG (NCT07769268)
- Testing
- Blancy Pro
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Melasma, Facial Melasma
Injectable Platelet-Rich Fibrin Versus Intradermal Tranexamic Acid for Melasma
Melasma is a chronic acquired hyperpigmentation disorder that commonly affects the face and has a significant impact on quality of life.
- Trial name
- NCT07540702
- Testing
- Injectable Platelet-Rich Fibrin, Tranexamic acid 100 mg/mL (Kapron)
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Kasr El Aini Hospital
Melasma (Facial Melasma), Melasma
Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma
It's a prospective, randomised, assessor-blinded clinical study comparing topical 30% metformin with Kligman's regimen for melasma in women aged 35-55 years at Fauji Foundation Hospital, Rawalpindi.
- Trial name
- Melasma (NCT07485777)
- Testing
- Topical 30% metformin cream, Kligman's Regimen
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Foundation University Islamabad
Melasma, Melasma (Facial Melasma)
Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma
The data will be collected after the permission of the ethical committee of hospital. Following the enrollment, patients will be selected by lottery in the two equal groups.
- Trial name
- NCT07732192
- Testing
- Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone
- Volunteers
- 128 people
- Sponsor
- Combined Military Hospital Abbottabad
Melasma
Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study
1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
- Trial name
- NCT07060157
- Testing
- resveratrol 1 % gel, TCA20%
- Where
- Egypt
- Volunteers
- 41 people
- Sponsor
- Assiut University
Rosacea, Acne
Clinical Evaluation and Study of the Efficacy of a Centella Asiatica-Infused Facial Mask on Discosmetic Dermatosis
The purpose of this study was to investigate the efficacy and safety of repairing facial mask containing Asiaticum asiatica in treating disjunctive skin diseases.
- Conditions
- Rosacea, Acne, Centella, Melasma
- Trial name
- NCT06763367
- Testing
- Face mask containing Centella sinensis
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Melasma
COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA
Melasma is a common acquired hyperpigmentation disorder that significantly affects quality of life. Various topical agents are used in its treatment, including Vitamin C and Niacinamide, both of which possess depigmenting…
- Trial name
- NCT07890571
- Testing
- Ascorbic acid, niacinamide
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pak Emirates Military Hospital
Epidermal Melasma, Facial Hyperpigmentation
Topical Metformin Versus Triple Regimen for Epidermal Melasma
Melasma is a common skin condition that causes dark brown patches, mainly on sun-exposed areas of the face. It is often persistent, may recur after treatment, and can affect a person's quality of life.
- Trial name
- MET-MEL (NCT07779811)
- Testing
- Topical 30% metformin cream, Topical Triple Regimen
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Combined Military Hospital, Pakistan
Female, With
New Treatment in Melasma
This randomized controlled trial aims to compare different therapeutic approaches for the treatment of melasma. Participants will be randomly allocated into three treatment groups receiving modified Kligman formula…
- Conditions
- Female, With, Facial, Melasma
- Trial name
- NCT07887399
- Testing
- Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Sohag University