Clinical trials: Melatonin
Delirium
The Effect of Melatonin on Postoperative Delirium in Elderly ICU Patients
Delirium in older patients is associated with increased mortality and health care costs. And delirium is frequent in intensive care unit (ICU).
- Trial name
- NCT02588742
- Testing
- Melatonin
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Yonsei University
Poor Sleep Quality, Leg Cramps, Nocturnal
The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps
Participants are being invited to take part in a research study. Before deciding whether to take part, it is important for participants to understand why the research is being done and what it will involve.
- Trial name
- MISIT (NCT07651514)
- Testing
- Magnesium and melatonin based multi-ingredient dietary supplementation
- Where
- 7 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- StudySetGo
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study
This purpose of this study is to test the effect of oral melatonin supplementation (8 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114360
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Melatonin Production
Melatonin Production Delay in Preterm Infants
Objective: Melatonin production is known to be delayed in preterm-born infants up to 6 months of age. This might be related to exposure of preterm infants to continuous lighting in the NICU during a critical period of pineal…
- Trial name
- NCT00775723
- Where
- Israel
- Volunteers
- 46 people
- Sponsor
- Tel Aviv University
Hypoxic Ischemic Encephalopathy
Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia
Hypoxic-Ischemic Encephalopathy (HIE) occurs in 20 per 1000 births. Only 47% of neonates treated with the state of the art therapy (induced systemic hypothermia) have normal outcomes.
- Trial name
- NCT02621944
- Testing
- Melatonin, Magnetic Resonance Imaging, Pharmacokinetics
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Florida
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Newborn Hypoxic Ischemic Encephalopathy
Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy
During the birth process certain conditions can cause oxygen delivery and/or blood flow to the baby's brain to become interrupted. This can cause permanent brain damage. Brain damage occurs in two phases.
- Trial name
- NCT01904786
- Testing
- Melatonin
- Where
- United States
- Sponsor
- St. Louis University
REM Sleep Behavior Disorder
Efficacy and Safety of Melatonin and Clonazepam for IRBD
This study aimed to evaluate influence of melatonin or clonazepam treatment on symptom and polysomnographic parameters in patients with idiopathic REM sleep behavior disorder.
- Trial name
- NCT03255642
- Testing
- Melatonin 2mg, ClonazePAM 0.5 MG
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Kyung Hee University Hospital at Gangdong
Impact Molar
Clinical and Radiographic Evaluation of Local Application of Melatonin on Postoperative Outcomes After Surgical Removal of Impacted Mandibular Third Molar
Clinical and Radiographic Evaluation of Local Application of Melatonin on Postoperative Outcomes after Surgical Removal of Impacted Mandibular Third Molar: A Randomized Controlled Study
- Trial name
- NCT07374536
- Testing
- Control, Melatonin gel
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Postoperative Delirium (POD), Abdominal Neoplasms
Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery
This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer…
- Trial name
- NCT07859488
- Testing
- Perioperative Biomarker Assessment, Confusion Assessment Method (CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatma Cigdem Ozakin
Benzodiazepines
The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients
We hypothesized that patient will success in benzodiazepine withdrawal if they get melatonin to solve sleep-problems which commonly occur during benzodiazepine withdrawal.
- Trial name
- NCT00261183
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Oral Mucositis (Ulcerative) Due to Radiation
Melatonin for Prevention of Radiation Induced Oral Mucositis
The main aim of this study was to evaluate the effectiveness of melatonin in prevention of radiation induced oral mucositis clinically and biochemically.
- Trial name
- NCT03833570
- Testing
- Rapid Release Capsules Melatonin, 10 mg, Miconaz oral gel, BBC oral spray
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hams Hamed Abdelrahman
Intraventricular Hemorrhage of Prematurity
Safety of Erythropoietin and Melatonin for Very Preterm Infants With Intraventricular Hemorrhage
Very preterm infants are prone to numerous medical complications with lifelong impact. Amongst the most serious neurologically are white matter injury (WMI), intraventricular hemorrhage (IVH) and the subsequent progression to…
- Trial name
- SCEMPI (NCT05617833)
- Testing
- MLT+EPO
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Johns Hopkins University
Infertility, Infertility (IVF Patients)
Melatonin Supplementation in Ovarian Response
Melatonin is a potent antioxidant, has been proposed to improve ovarian response and oocyte quality in assisted reproductive technologies (ART).
- Conditions
- Infertility, Infertility (IVF Patients), Infertile Women Undergoing IVF or ICSI
- Trial name
- NCT07343947
- Testing
- 5mg melatonin supplementation
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type 2, Insomnia
A Study of the Efficacy of Prolonged-Release Melatonin Versus Placebo in Diabetic Patients Suffering From Insomnia
Objective - Type 2 uncontrolled diabetic patients often have low endogenous melatonin and suffer from sleep disorders. The effect of a prolonged-release melatonin (PRM) formulation on glucose lipid metabolism and sleep is studied…
- Trial name
- NCT00869128
- Testing
- Circadin
- Volunteers
- 36 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Edentulous; Alveolar Process, Atrophy
Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation
melatonin proved an ability to repair bone defects and enhance osseointegration of dental implants. Also, hyaluronic acid has osteopromoting properties.
- Trial name
- NCT04625179
- Testing
- Melatonin and hyaluronic acid and sinus membrane elevation, sinus membrane elevation without any materials
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Cardiovascular Risk Factor
Melatonin and Salt on Blood Vessel Function
Increased dietary sodium causes increases in oxidative stress and damages blood vessels. Americans eat more than the recommended amount of sodium.
- Trial name
- NCT04325191
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Delaware