Clinical trials: Membranous
Membranous Nephropathy, Lupus Nephritis (LN)
A Study to Evaluate the Efficacy, Safety, and Tolerability of Human Sialidase Fusion Protein (HLX79) in Combination With Rituximab Injection Versus Placebo in Patients With Active Glomerulonephritis
The primary objectives of this clinical trial is to evaluate the safety and tolerability of HLX79 in combination with HLX01 versus placebo in combination with HLX01 in the treatment of glomerulonephritis.
- Trial name
- NCT07038382
- Where
- 17 sites in China
- Volunteers
- 24 people
- Sponsor
- Shanghai Henlius Biotech
Tendon Adhesion, Tenolysis
Surgical Release of Hand Tendons With Wrapping of the Released Tendon Using an Amniotic Membrane
The goal of this clinical trial is to evaluate whether an amniotic membrane can function as an effective anti-adhesive barrier following surgical release of tendon adhesions.
- Trial name
- NCT06723782
- Testing
- AMTRIX-D
- Where
- France
- Volunteers
- 18 people
- Sponsor
- TBF Genie Tissulaire
Diabetic Foot Ulcers, Wound Care
A Randomized Comparison of AmnioClear™ Human Allograft Amniotic Membrane vs. Moist Wound Dressing in the Treatment of Diabetic Wounds
This research project is testing a product called AmnioClear™ which is an amniotic membrane graft processed for Liventa Bioscience formerly AFCell Medical.
- Trial name
- NCT02120755
- Testing
- AmnioClear™ Human Allograft Amniotic Membrane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Liventa Bioscience
Glomerulonephritis, Membranous, antiPLA2R Positive
Trial to Assess Safety and Efficacy of MOR202 in Anti-PLA2R + Membranous Nephropathy (aMN)
This is an open-label, multicentre study to characterize the safety and efficacy of the human anti-CD38 antibody MOR202 in adult subjects with in Anti-PLA2R Antibody Positive Membranous Nephropathy (newly…
- Trial name
- M-PLACE (NCT04145440)
- Testing
- MOR202
- Where
- 45 sites in United States, Australia and 7 more
- Volunteers
- 31 people
- Sponsor
- HI-Bio, A Biogen Company
Haemophilia A (Moderate or Severe), Hemophilia, Classic
A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis
The rationale for conducting this open-label phase 4 study is to assess whether once-weekly prophylaxis with efanesoctocog alfa (50 IU/kg) improves the disease course of existing synovial hypertrophy and prevents the risk of…
- Conditions
- Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia
- Trial name
- NCT06752850
- Testing
- Efanesoctocog alfa
- Where
- 10 sites in Italy, Norway and 2 more
- Volunteers
- 37 people
- Sponsor
- Swedish Orphan Biovitrum
Metastatic Prostate Cancer
Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of multiple anti-cancer agents in participants with metastatic prostate cancer.
- Trial name
- PROSPECTOR (NCT07590934)
- Testing
- AZD2265 (FPI-2265), Palacaparib (AZD9574), Docetaxel
- Where
- 38 sites in United States, Australia and 5 more
- Volunteers
- 152 people
- Sponsor
- AstraZeneca
Anesthesia of Tympanic Membrane
Healthy Volunteer Study
The study will recruit healthy volunteers to undergo the iontophoresis procedure using the Acclarent Iontophoresis System with Headset.
- Trial name
- IPSHS (NCT01346332)
- Testing
- Iontophoresis System with Headset
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Integra LifeSciences Corporation
Prostate Cancer
A Phase 1 Trial for Evaluation of the Safety, Pharmacokinetics, and [18F] Radiation Dosimetry of CTT1057
The purpose of this study is to test a novel diagnostic Positron Emission Tomography (PET) imaging agent for safety and biodistribution.
- Trial name
- NCT02916537
- Testing
- CTT1057, Prostatectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cancer Targeted Technology
Prostate Cancer
A Trial of CTT1403 for Metastatic Castration Resistant Prostate Cancer
The purpose of this study is to find the highest dose level of study drug, CTT1403, that can be safely administered to patients with metastatic castration resistant prostate cancer (mCRPC).
- Trial name
- NCT03822871
- Testing
- CTT1403, CTT1057, 68Ga-PSMA-11
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Cancer Targeted Technology
Wounds
Use of the Amniotic Membrane in Large Wound Epithelialization
The purpose of this study is to analyze the security application of the amniotic membrane in extensive wounds in the granulation phase.
- Trial name
- MA/GH (NCT01824381)
- Testing
- Place amniotic membrane in large wounds, Obtaining and Cryopreservation of amniotic membrane, amniotic membrane
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Red de Terapia Celular
Macular Holes, Retinal Detachment
Amniotic Membrane Visio-AMTRIX in Recurrent Macular Hole
The purpose of this open, multicenter trial is to assess the impact of the use of an amniotic membrane graft on the closure of macular hole-associated retinal detachment in patients with failed previous macular surgery.
- Trial name
- NCT05191628
- Testing
- Visio-AMTRIX
- Where
- France
- Volunteers
- 12 people
- Sponsor
- TBF Genie Tissulaire
Type 2 Inflammatory Disorders
Compassionate Use or Expanded Access of Dupilumab
Provide Compassionate Use or Expanded Access of Dupilumab
- Trial name
- NCT04776694
- Testing
- Dupilumab
- Sponsor
- Regeneron Pharmaceuticals
Guided Tissue Regeneration, Collagen Membrane
Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration
The goal of this clinical trial is to evaluate clinically and radiographically effectiveness and products safety of the collagen membrane (FormaAid®) in the treatment of periodontal regeneration using guided tissue regeneration…
- Conditions
- Guided Tissue Regeneration, Collagen Membrane, Dental Diseases
- Trial name
- NCT06252935
- Testing
- FormaAid, Bio-Gide
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Maxigen Biotech Inc.
Kidney Failure
Quantitative Mass Transfer of SFP-iron From Dialysate to Blood in CKD-HD Patients
The purpose of this study is to determine the quantity of iron derived from SFP that is transferred from the dialysate to patients during a single dialysis session.
- Trial name
- NCT01894906
- Testing
- Soluble Ferric Pyrophosphate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rockwell Medical Technologies, Inc.
Extracorporeal Membrane Oxygenation Complication
EUROSETS ECMO Study in Clinical Extracorporeal Life Support Applications
This is a prospective single-center study designed for evaluation of safety and performance of the Conformitè Europëenne (CE)-marked EUROSETS ECMOLIFE SYSTEM, composed by: ECMOLIFE console, ECMO TUBING SET, ECMO OXYGENATOR and…
- Trial name
- NCT05163925
- Testing
- Eurosets ECMO Life System
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Eurosets S.r.l.
Nephrotic Syndrome Due to Idiopathic Membranous Nephropathy, Severe Proteinuria Due to Idiopathic Membranous Nephropathy
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of Treatment With AP1189 in Patients With iMN and Severe Proteinuria
This study is an exploratory, randomized, double-blind, multicenter, placebo-controlled study with repeated doses of AP1189. The study population will consist of patients with idiopathic membranous nephropathy (iMN) and severe…
- Trial name
- NCT04456816
- Testing
- 100 mg AP1189
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- SynAct Pharma Aps
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Prostate Cancer
Imaging of Residual Tumor During Prostatectomy
Prostate Cancer is the most common cancer in men, affecting about as many men as women diagnosed with breast cancer, and killing about as many men per year as breast cancer kills women.
- Trial name
- NCT01173146
- Where
- United States
- Sponsor
- Spectros Corporation
Advanced Age-related Macular Degeneration
Intravitreal LFG316 in Patients With Advanced Age-related Macular Degeneration
This study will assess the safety, tolerability, and serum pharmacokinetics of intravitreal LFG316 in patients with advanced age-related macular degeneration.
- Trial name
- NCT01255462
- Testing
- LFG316
- Where
- 8 sites in United States
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Anti-Glomerular Basement Membrane Disease
A Clinical Trial With KJ103 in Anti-GBM Disease
An open-label, single-arm Phase II study to evaluate the preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenicity of KJ103 in patients with anti-GBM disease.
- Trial name
- NCT06607016
- Testing
- KJ103 for Injection, Cyclophosphamide, Glucocorticoids
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai Bao Pharmaceuticals Co., Ltd.