Clinical trials: Membranous
Rotator Cuff Tear, Rotator Cuff Tendinopathy
The Effect of Amniotic Membrane Injection as An Addition to Physical Therapy in Patients With Rotator Cuff Tear
Rotator cuff tear (RCT) is a commonly seen pathology in shoulder disease, which causes significant disability in daily living and work.
- Conditions
- Rotator Cuff Tear, Rotator Cuff Tendinopathy, Ultrasonography
- Trial name
- NCT05320419
- Testing
- Amniotic membrane preparation and injection (AM group), Physiotherapy (PT group)
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Sudden Hearing Loss
Efficacy and Safety of Intracochlear Injection of Glucocorticoid Through the Round Window Membrane in Patients With Profound or Complete Sudden Sensorineural Hearing Loss
Safety and efficacy of intracochlear injection of glucocorticoid through the round window membrane in patients with profound or complete sudden sensorineural hearing loss
- Trial name
- NCT07814677
- Testing
- intracochlear injection of triamcinolone acetonide through the round window membrane, intratympanic dexamethasone injection through the tympanic membrane
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)
Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients.
- Conditions
- Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications
- Trial name
- UPV-ECMO (NCT03041428)
- Testing
- Ultraprotective ventilation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Primary Membranous Nephropathy
Clinical Study of Rituximab Combined With Corticosteroids or Rituximab Monotherapy in the Treatment of Primary Membranous Nephropathy
This was a prospective, randomized, multicenter clinical trial. Seventy-eight patients with primary membranous nephropathy (PMN) were randomly divided into intervention or control group.
- Trial name
- NCT05514015
- Testing
- rituximab combined with corticosteroids, rituximab
- Where
- China
- Volunteers
- 78 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Lung Transplant, Pulmonary Hypertension
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
The purpose of this study is to determine if transseptal extra-corporeal membrane oxygenation (ECMO) can bridge pulmonary hypertension- right heart failure (PH-RVF) patients to lung transplant safely.
- Trial name
- NCT06770023
- Testing
- Protek Solo Transseptal Cannula
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Alveolar Buccal Bone Dehiscences, Socket Type 3 Subclass B
Evaluation Of The Success Rate of NOVAMag® SHIELD
This study hypothesizes that the SHIELD technique, when combined with a suitable bone graft material, enables successful immediate implant placement in Type 3 extraction sockets with buccal bone dehiscence, regardless of the…
- Conditions
- Alveolar Buccal Bone Dehiscences, Socket Type 3 Subclass B, Socket Type 3 Subclass C
- Trial name
- NOVASHIELD-RCT (NCT07533110)
- Testing
- SHIELD technique with NOVAMag membrane
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Uveitis, Cancer
Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study
This study will evaluate whether therapy that suppresses the immune system given to treat inflammatory diseases of the eye is associated with a greater risk of death and of cancer.
- Conditions
- Uveitis, Cancer, Infection, Mortality
- Trial name
- NCT00116090
- Where
- 4 sites in United States
- Volunteers
- 6,300 people
- Sponsor
- National Eye Institute (NEI)
Bronchopulmonary Dysplasia, Hyaline Membrane Disease
Inhaled Beclomethasone to Prevent Chronic Lung Disease
To test if inhaled glucocorticoids, early in the course of respiratory failure in premature infants, permit normal lung growth and differentiation, thus preventing development of bronchopulmonary dysplasia.
- Conditions
- Bronchopulmonary Dysplasia, Hyaline Membrane Disease, Lung Diseases
- Trial name
- NCT00000576
- Testing
- beclomethasone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Fuchs' Dystrophy, Bullous Keratopathy
Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)
The purpose of this study is to compare two different commonly used steroid dosing regimens after Descemet's membrane endothelial keratoplasty (DMEK) transplant surgery.
- Trial name
- NCT01448213
- Testing
- Prednisolone acetate, Fluorometholone
- Where
- 2 sites in United States, Germany
- Volunteers
- 264 people
- Sponsor
- Price Vision Group
Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs)
HEAL-4: Real-World Effectiveness of 4 Amniotic Allografts Adjunctive to Standard Care in DFU, VLU, and PU
This retrospective multi-site observational cohort study uses electronic health records (EHR) from U.S. wound care centers to evaluate the effectiveness of four amniotic membrane allografts (Acesso DL, Acesso TL, Neostim DL…
- Conditions
- Diabetic Foot Ulcer (DFU), Venous Leg Ulcers (VLUs), Pressure Ulcers, Bedsores, Decubitus Ulcer
- Trial name
- HEAL-4 (NCT07223515)
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Dynamic Medical Services dba Acesso Biologics
Diabetic Foot Ulcer (DFU), Lower Extremity
Matrion Decellularized Placental Membrane Versus Conventional Wound Management in Subjects With Diabetic Foot Ulcers
This study will evaluate Matrion™ (LifeNet Health, Inc., Virginia Beach, VA), a placental membrane product, as a treatment for diabetic foot ulcers compared to conventional wound care.
- Trial name
- NCT07116876
- Testing
- Graft Application, Wound Dressing Material
- Where
- 17 sites in United States
- Volunteers
- 120 people
- Sponsor
- LifeNet Health
Horizontal Ridge Deficiency
Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration
this study compares 2 techniques in guided bone regeneration for horizontal ridge augmentation in aesthetic zone
- Trial name
- VIP-CT (NCT05813340)
- Testing
- Vascularized inter-positional periosteal connective tissue flap
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premature Rupture of Fetal Membranes
Evaluation of CRB in PROM Patients
The CRB study is designed to study the safety and effectiveness of the Cook Cervical Ripening Balloon (CRB) for the induction of labor in term and near-term patients with premature rupture of membranes (PROM).
- Trial name
- NCT01736852
- Testing
- CRB, Pitocin
- Where
- 4 sites in United States
- Volunteers
- 129 people
- Sponsor
- Cook Group Incorporated
Tympanic Membrane Perforation
Fat Graft Myringoplasty With and Without Platelet Rich Plasma (PRP) for Treating Smaller Tympanic Membrane Perforations
The current standard treatment for chronic tympanic membrane perforations (TMP) involves having fat grafted from the patient and inserted into the ear, through the perforation, to promote healing using the fat graft myringoplasty…
- Trial name
- NCT01958749
- Testing
- Fat graft with Platelet Rich Plasma
- Where
- 4 sites in Canada, United Kingdom
- Sponsor
- Nova Scotia Health Authority
Socket Sealing, Free Gingival Graft
Clinical and Histological Assessment of Free Gingival Graft or Collagen Matrix for Socket Sealing After Bone Grafting
The goal of this study was to compare, clinical and histologically, the use of the suine collagen matrix (Mucograft Seal [MS], Geisthlich®) and the free gingival graft (FGG) for the alveolar sealing after inserted bone graft…
- Conditions
- Socket Sealing, Free Gingival Graft, Collagen Membrane
- Trial name
- NCT05448040
- Testing
- Socket preservation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Salgado de Oliveira
Recurrent Acute Otitis Media
Effect of Ventilation Tubes in Otitis-prone Children
The purpose of this study is to investigate the effects of ventilation tubes in children with recurrent ear infections. By drawing lots, young children with recurrent ear infections will be assigned to one of two groups…
- Trial name
- NCT05348291
- Testing
- ventilation tubes
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Lund University
Diabetic Foot Ulcer
Comparative Study of Two Application Regimens of Amniotic Membrane Wound Graft In the Management of Diabetic Foot Ulcers
The purpose of this study is to determine whether a weekly application of EpiFix human amniotic membrane is more effective than a biweekly application (every two weeks) in the treatment of diabetic foot ulcers.
- Trial name
- NCT01657474
- Testing
- Weekly application of EpiFix plus standard of care, Biweekly application of EpiFix plus standard of care
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- MiMedx Group, Inc.
Prostate Cancer
Study to Assess [177Lu]Lu-PSMA-R2 (AAA602) and [225Ac]Ac-PSMA-R2 (AAA802) in Participants With PSMA-positive HRLPC
The purpose of this trial is to learn more about the effects of AAA602 and AAA802 in men with prostate-specific membrane antigen (PSMA) positive high-risk localized prostate cancer (HRLPC) before surgery to remove the prostate…
- Trial name
- NeoPSMA (NCT06881823)
- Testing
- AAA602, AAA802, Gallium (68Ga) gozetotide
- Sponsor
- Novartis Pharmaceuticals
Extracorporeal Membrane Oxygenation Complication
The ECMO-Free Trial
Decannulation from venovenous extracorporeal membrane oxygenation (VV-ECMO) at the earliest and safest time would be expected to improve outcomes and reduce cost.
- Trial name
- NCT05486559
- Testing
- ECMO-free protocol, Usual Care
- Where
- 8 sites in United States, Canada
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation
Mechanical Respiratory/circulatory Support in Patients with Pulmonary Thrombectomy
Pulmonary embolism (PE) results from embolization of venous thrombi in the branches of the pulmonary arteries. Although anticoagulation is usually the preferred method of treatment, patients with high-risk and/or…
- Conditions
- Pulmonary Embolism and Thrombosis, Extracorporeal Membrane Oxygenation, Percutaneous Pulmonary Thrombectomy
- Trial name
- NCT06525480
- Testing
- Percutaneous pulmonary thrombectomy
- Where
- Spain
- Volunteers
- 77 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
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