Clinical trials: Membranous
Age Related Macular Degeneration, Choroidal Neovascular Membrane
A Study of Intravitreal Injections of 2.0mg Ranibizumab in Subjects With Chronic Fluid On OCT Post Multiple Injections With Ranibizumab (Super-dose Anti-VEgf SAVE Trial)
The purpose of this study is to determine whether 2.0mg Ranibizumab is effective in the treatment of recurrent fluid.
- Conditions
- Age Related Macular Degeneration, Choroidal Neovascular Membrane, Subfoveal Neovascular Age-Related Macular Degeneration, Macular Degeneration
- Trial name
- SAVE (NCT01025232)
- Testing
- Ranibizumab
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- David M. Brown, M.D.
Sepsis, Necrotizing Enterocolitis
Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation
Circulating markers to diagnose complications (sepsis, necrotizing enterocolitis) in preterm infants are often inaccurate, partly due to the lack of comprehensive studies with temporal evaluation from birth until a disease onset.
- Conditions
- Sepsis, Necrotizing Enterocolitis, Chorioamnionitis, Feeding Intolerance
- Trial name
- NEOINFLAM (NCT03320785)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Per Torp Sangild
Cardiopulmonary Resuscitation, Cardiac Arrest
Extracorporeal Membrane Oxygenation Effect in Prolonged Cardiopulmonary Resuscitation
Analysis of the patients' data who were rescued with extracorporeal membrane oxygenation and without ECMO. The survival rate and the weaning rate were analyzed to see the effect of ECMO on the prolonged CPR.
- Conditions
- Cardiopulmonary Resuscitation, Cardiac Arrest, Ventricular Tachycardia, Ventricular Fibrillation
- Trial name
- NCT00173615
- Testing
- Extracorporeal membrane oxygenation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Distress Syndrome
Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
In patients with severe acute respiratory distress syndrome, extracorporeal membrane oxygenation (ECMO), which also as known as extracorporeal life support, may be used.
- Trial name
- PiCCMO (NCT05164484)
- Testing
- Transpulmonary thermodilution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healing Wound
Evaluation of the Effectiveness of an Amnion-chorion Membrane for Alveolar Ridge Preservation
This study will examine whether adding an amnion-chorion membrane on top of the traditionally used collagen plug will lead to more bone formation compared to the collagen plug only.
- Trial name
- NCT05592158
- Testing
- Socket preservation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Veno-arterial Extra-Corporeal Membrane Oxygenation, Health Related Quality of Life
Health-related Quality of Life in Adults After Veno-arterial Extra-Corporeal Membrane Oxygenation Which is a Salvage Therapy Used in Patients With Severe Respiratory or Cardiac Failure Who Have Not Responded to Maximal Conventional Medical Therapy
Extracorporeal Membrane Oxygenation (ECMO) is a salvage therapy used in patients with refractory cardiogenic shock. This rescue technique is associated to a high mortality rate and to many complications that can impact the…
- Trial name
- NCT04653298
- Testing
- Evaluation of quality of life, comorbidities and return to work status
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Ophthalmologic Complication, Epiretinal Membrane
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
Assessing metamorphopsia and quality of vision pre and post epiretinal and macular hole surgery
- Conditions
- Ophthalmologic Complication, Epiretinal Membrane, Metamorphopsia, Macular Holes
- Trial name
- MQUEST (NCT05171621)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Hayley Westwood
MERS-CoV Infection, Refractory Hypoxemia
Saudi Outcomes of ECMO-treated MERS-CoV Patients
A highly pathogenic human coronavirus causing respiratory disease emerged in Saudi Arabia in 2012. This viral infection termed Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with high mortality rate in…
- Trial name
- NCT02627378
- Testing
- Extracorporeal Membrane Oxygenation, Non Extracorporeal Membrane Oxygenation
- Where
- Saudi Arabia
- Volunteers
- 35 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Neonatal Respiratory Failure
Hypothermia During ECMO to Decrease Brain Injury
Newborn infants with severe respiratory failure are treated with extracorporeal membrane oxygenation (ECMO), a modified form of cardiopulmonary bypass.
- Trial name
- NCT01675388
- Testing
- Hypothermia
- Where
- United States
- Sponsor
- Sood, Beena G., MD, MS
Otosclerosis, Tympanic Membrane Perforation
Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease
We study audiometric parameters including Transient Otoacoustic emissions, pure-tone audiometry for air- and bone-conduction, and spondaic speech recognition thresholds for air- and bone conduction in a pre- and postoperative…
- Trial name
- NCT00222417
- Testing
- myringoplasty, Stapes surgery
- Where
- Norway
- Sponsor
- University Hospital of North Norway
Heart Transplant Failure, Determination of Death
Evaluation of Safety and Effectiveness of The SherpaPak in Donation After Circulatory Death Heart Transplantation
This is a prospective, pilot trial to evaluate the safety and effectiveness of The Paragonix SherpaPak™ Cardiac Transport System ("SherpaPak CTS") in transportation of cardiac allografts recovered from donors after circulatory…
- Conditions
- Heart Transplant Failure, Determination of Death, Outcomes Research, Extracorporeal Membrane Oxygenation
- Trial name
- NCT05038943
- Testing
- Paragonix SherpaPak Cardiac Transport System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Nebraska
Human Immunodeficiency Virus, HIV
Fetal HIV Transmission Risk and Duration of Membrane Rupture
In optimally managed HIV+ women with undetectable viral loads, who are on HAART and also receiving intrapartum IV ZDV, the risk of vertical transmission of HIV is independent of the length of time of rupture of membranes.
- Trial name
- NCT01616823
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- Unity Health Toronto
Sinus Lift Surgery Complications, Maxillary Sinus Elevation
Predictors For Transosseous Maxillary Sinus Lift Complications
This prospective cohort study aims to identify clinical and anatomical predictors for complications following transosseous maxillary sinus lift procedures using the Versah (Densah burs) technique.
- Trial name
- PMSL (NCT07017413)
- Testing
- Transosseous Maxillary Sinus Lift using Osseodensification
- Where
- 2 sites in Iraq
- Volunteers
- 60 people
- Sponsor
- University of Baghdad
Idiopathic Membranous Nephropathy
Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy
Idiopathic membranous nephropathy (IMN) remains a common cause of the nephrotic syndrome in adults. There are few randomized clinical trials regarding the therapeutic effect of mycophenolate mofetil in patients with Idiopathic…
- Trial name
- MMF-STOP-IMN (NCT03170323)
- Testing
- Mycophenolate Mofetil, Cyclosporins
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Guangdong Provincial People's Hospital
Extracorporeal Membrane Oxygenation
Extracorporeal Membrane Oxygenation (ECMO): Blood Cells
The objective of the study is to predict outcomes of patients on extracorporeal membrane oxygenation (ECMO) therapy by correlating cytokines and inflammatory cell patterns to clinical outcomes using data collected in the ECMO…
- Trial name
- NCT02748668
- Testing
- Blood specimen collection
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Corewell Health West
Epidermolysis Bullosa Dystrophica, Recessive, Ulcer
A Comparative Study of the Healing of Chronic Ulcers of Recessive Epidermolysis Bullosa : Dressing vs Amniotic Membrane
Skin wounds of Recessive Epidermolysis Bullosa Dystrophica (REBD) involve pain, superinfection, protein-losing, inflammation, and joint contractures are the bed of squamous cell carcinoma.
- Trial name
- MABUL (NCT02286427)
- Testing
- Amniotic Membrane
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Premature Rupture of Membranes
Melatonin, Soluble Urokinase-type Plasminogen Activator Receptor, and Orosomucoid 2 Levels in PPROM
Introduction: To evaluate the maternal blood serum melatonin, soluble urokinase-type plasminogen activator receptor, and orosomucoid 2 levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to…
- Trial name
- melatonin&PROM (NCT04588220)
- Testing
- Obstetric ultrasound and fetal-maternal assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Macular Edema, Epiretinal Membrane
Intravitreal Dexamethasone Implant for Persistent Macular Thickening and Edema After Vitrectomy for Epiretinal Membrane
This study seeks to evaluate the effect of the intravitreal 0.7mg dexamethasone implant on central macular thickness and visual acuity in those patients with persistent macular edema after pars plana vitrectomy for epiretinal…
- Conditions
- Macular Edema, Epiretinal Membrane, Vitrectomy
- Trial name
- DEMO (NCT02995746)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Metastatic Castration-resistant Prostate Cancer, mCRPC
The Safety and Dosimetry Study of 177Lu-LNC1003 Injection
This proposal is a phase I, open-label study of a 3-Dose Regimen of Escalating Doses of 177Lu-LNC1003 Injection in patients with PSMA-positive mCRPC. In the clinical development, we aim to demonstrate the following: 1.
- Trial name
- NCT06237491
- Testing
- 177Lu-LNC1003 Injection group 1, 177Lu-LNC1003 Injection group 2, 177Lu-LNC1003 Injection group 3
- Volunteers
- 12 people
- Sponsor
- Yantai LNC Biotechnology Singapore PTE. LTD.
Epiretinal Membrane, Macular Pucker
Perioperative Topical Nepafenac After Epiretinal Membrane Surgery
This prospective comparative study evaluates whether perioperative topical nepafenac improves early anatomical and functional recovery after pars plana vitrectomy with epiretinal membrane and internal limiting membrane peeling.
- Trial name
- NEPERM (NCT07736690)
- Testing
- Nepafenac 0.1% Ophthalmic Suspension, Pars Plana Vitrectomy With Epiretinal Membrane and Internal Limiting Membrane Peeling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Yildirim Beyazıt University
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