Clinical trials: Membranous
Horizontal Ridge Deficiency
Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration
this study compares 2 techniques in guided bone regeneration for horizontal ridge augmentation in aesthetic zone
- Trial name
- VIP-CT (NCT05813340)
- Testing
- Vascularized inter-positional periosteal connective tissue flap
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Macular Hole
Internal Limiting Membrane Peeling for Large Macular Holes
Rational of the study: for macular holes larger than 400 µm the rate of failure is of more than 20%. It is for these eyes that it is necessary to show the benefit of internal limiting membrane (ILM) peeling in term of vision and…
- Trial name
- NCT00190190
- Testing
- With Peeling of Limiting the Intern of the Retina, Internal limiting membrane peeling
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Radial Head Fractures
Radiological and Clinical Outcome After Screw Osteosynthesis of Radial Head Fractures
This cohort study investigates radiological and clinical outcome after screw osteosynthesis of radial head fractures with associated injuries (such as rupture of the interosseous membrane and collateral ligaments).
- Trial name
- RadioHead (NCT03944590)
- Testing
- patient survey, analysis of radiographs
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiogenic Shock, Acute Myocardial Infarction
Revascularization Strategy of Multivessel Disease for Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock Undergoing Veno-arterial Extracorporeal Membrane Oxygenator
This study is a prospective, open-label, two-arm, randomized multicenter trial to identify whether immediate multi-vessel PCI would be better in clinical outcomes compared with culprit lesion-only PCI for AMI and multi-vessel…
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, Multi Vessel Coronary Artery Disease, Extracorporeal Membrane Oxygenation
- Trial name
- RESCUE-SHOCK (NCT05527717)
- Testing
- Culprit lesion only PCI, Immediate multi-vessel PCI
- Where
- South Korea
- Volunteers
- 560 people
- Sponsor
- Samsung Medical Center
Patients in Septic Shock
The Effects of a Polyethyleneimine-coated Membrane (oXiris™) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxin™) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)
Septic shock has a high mortality risk despite the availability of various treatments. Endotoxin, that is present in the cell walls of gram-negative bacteria, is a potent trigger of innate immunity.
- Trial name
- NCT01948778
- Testing
- oXiris™ filter, Toraymyxin Filter, Standard of Care
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Zurich
Surgery for Cataract, Surgery for and Idiopathic Epiretinal Membrane
Validation of a Prognostic Score for Good Visual Recovery at One Year Following Combined Surgery for Cataract and Idiopathic Epiretinal Membrane
The prevalence of idiopathic epiretinal membranes (ERM) in people over 50 is estimated at 6 to 19%. Even though most cases show very few symptomats, they may induce alterations of the underlying retina and lead to visual…
- Trial name
- PROCATMER (NCT03329976)
- Testing
- measurement of visual acuity
- Where
- France
- Volunteers
- 164 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Renal Cell Carcinoma
Moesin Expression in Clear Cell Renal Cell Carcinoma
Renal cell carcinoma (RCC) is the most frequently occurring primary renal neoplasm. There are several histological variants of RCC that are associated with variable prognostic outcomes.
- Trial name
- NCT06055660
- Testing
- Immunohistochemical detection of Moesin in Clear cell Renal Cell Carcinoma
- Volunteers
- 50 people
- Sponsor
- Sohag University
Peanut Allergy
A Study to Evaluate Safety, Tolerability and Immune Response in Adolescents Allergic to Peanut After Receiving Intradermal Administration of ASP0892 (ARA-LAMP-vax), a Single Multivalent Peanut (Ara h1, h2, h3) Lysosomal Associated Membrane Protein DNA Plasmid Vaccine
The purpose of this study is to evaluate the safety and tolerability of ASP0892 after intradermal (ID) injection in adolescent participants with peanut allergy.
- Trial name
- NCT03755713
- Testing
- ASP0892
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Preterm Birth, Preterm Labor
To Optimize Antenatal Management of Women With Pre Term Labor Using Amniocentesis
Implementation of prediction models of risk of spontaneous delivery within 7 days or of intra-amniotic infection in women with preterm labor and intact membranes
- Conditions
- Preterm Birth, Preterm Labor, Intra-amniotic Infection, Amniocentesis Affecting Fetus or Newborn
- Trial name
- OPTIM-PTL (NCT04831086)
- Testing
- Steroid Drug, Tocolytic Agents
- Where
- Spain
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Burnout, Caregiver, Extracorporeal Membrane Oxygenation Complication
Impact of Extra Corporal Membrane Oxygenation Services on Burnout Development in Intensive Care Units.
The burnout phenomenon first came to clinical science 50 years ago. It is exponentially rising worldwide which prompted its discoverers to develop the most popular tool for its assessment, known as the Maslach burnout inventory…
- Conditions
- Burnout, Caregiver, Extracorporeal Membrane Oxygenation Complication, Intensive Care Unit
- Trial name
- burnout (NCT04620005)
- Testing
- Observational
- Where
- Qatar
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Physical Performance, Cognitive Function
The Impact of Omega-3 Fatty Acid Supplementation on the Composition of Erythrocyte Membranes in Athletes
The aim of this study is to evaluate the effects of omega-3 fatty acid supplementation on the Omega-3 Index, erythrocyte membrane composition, cognitive function, hormonal profile, speed, endurance performance, and hematological…
- Conditions
- Physical Performance, Cognitive Function, Sports Nutrition
- Trial name
- OMEGA-PERFORM (NCT07768423)
- Testing
- EPA + DHA supplements
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Infection
EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION
The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.
- Trial name
- EC-MOTION (NCT02917486)
- Testing
- blood sample
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Rennes University Hospital
Alveolar Cleft
Double Closure of Nasal Layer in Alveolar Cleft Grafting
The aim of this prospective study is to evaluate both clinically and radiologically the efficacy of using autologous platelets rich fibrin versus collagen membrane for nasal layer closure in secondary alveolar cleft repair.
- Trial name
- NCT05988086
- Testing
- platelet rich fibrin, collagen membrane
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tanta University
Respiratory Distress Syndrome, Adult, Multi-antibiotic Resistance
Multi-drug Resistant Gram-negative Bacteria and Veno-venous Extracorporeal Membrane Oxygenation (ECMO)
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a life-support technique used in patients with most severe acute respiratory distress syndrome (ARDS).
- Trial name
- MDR-ECMO (NCT06199141)
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Padova
Chronic Myeloid Leukemia
Effect of Pharmacogenetics on Imatinib Plasma Level and Response
Imatinib, the tyrosine kinase inhibitor, is used for treatment of Philadelphia positive chronic myeloid leukemia. Despite its efficacy and favorable pharmacokinetic profile, there is a large inter-individual variability in…
- Trial name
- NCT03262974
- Testing
- PCR, HPLC-UV
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Glomerulonephritis, Membranous
A Phase 3 Study of Inebilizumab in Participants With Primary Membranous Nephropathy
The primary objective of this study to evaluate the efficacy of inebilizumab on primary membranous nephropathy (PMN) disease activity as measured by complete remission in participants with PMN.
- Trial name
- MOMENT (NCT07851220)
- Testing
- Inebilizumab, Tacrolimus
- Where
- 4 sites in United States
- Volunteers
- 159 people
- Sponsor
- Amgen
Tympanic Membrane Perforation
Tympanoseal (Tympanic Membrane Device) Clinical Study
The purpose of this investigational study is to assess the ability of Tympanoseal (sodium/calcium alginate), an investigational device, to act as a scaffold during healing of the tympanic membrane.
- Trial name
- NCT02918942
- Testing
- Tympanoseal
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Grace Medical, Inc.
Preterm Premature Rupture of Membranes
Magnesium Sulfate Versus Placebo for Tocolysis in PPROM
Study compares the outcomes of women between 26 and 32 wks gestation with rupture of membranes. Women randomized to receive tocolysis with magnesium sulfate x 48 hrs or placebo of saline IV x 48 hrs.
- Trial name
- NCT00463736
- Testing
- Magnesium sulfate
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Regional Obstetrical Consultants
Fuchs' Endothelial Corneal Dystrophy, Bullous Keratopathy
Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
The purpose of this study is evaluate the outcome after posterior lamellar keratoplasty (DMEK and Ultra-thin DSAEK) for corneal transplantation.
- Conditions
- Fuchs' Endothelial Corneal Dystrophy, Bullous Keratopathy, Iridocorneal Endothelial Syndrome, Posterior Polymorphous Dystrophy
- Trial name
- NCT02020044
- Testing
- Endothelial Keratoplasty
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
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