Clinical trials: Membranous
Non-healing Wound, Diabetic Foot
AMNIODERM+ Medical Device Clinical Study
This is retrospectively-prospective clinical trial with medical device AMNIODERM+ intended for the non-healing wounds. Retrospective data will contain information about the subject's history and wound treatment by SoC.
- Trial name
- AMNIODERM+ (NCT06442865)
- Testing
- AMNIODERM+
- Where
- Slovakia
- Volunteers
- 20 people
- Sponsor
- BioHealing s.r.o.
Ridge Augmentation
Magnesium NOVAMag® Membrane vs. Collagen Jason® Membrane in Patients Requiring Guided Bone Regeneration
The NOVAMag® membrane is a medical device approved in the EU, and is a completely resorbable and biodegradable metal membrane. This medical device is used in the treatment of bone defects in the oral cavity.
- Trial name
- NCT06059898
- Testing
- GBR surgery including membrane placement, Biopsy
- Where
- 5 sites in Austria, Denmark and 1 more
- Volunteers
- 106 people
- Sponsor
- Botiss Medical AG
Limbal Stem Cell Deficiency
ABCB5 as a Prognostic Marker in Survival of Cultivated Limbal Stem Cell Transplantation
In this study the prognostic value of ABCB5 in survival of the limbal stem cell transplantation expanded in vitro on amniotic membrane for corneal surface reconstruction in patients with limbal stem cell deficiency will be…
- Trial name
- NCT02579993
- Testing
- Pannus and conjunctival dissection, Human cultivated limbal stem cell transplantation
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Macular Holes
Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane Flap in Idiopathic Large Macular Holes
The human amniotic membrane (hAM) patch, introduced by Rizzo et al. in 2018, showed a 100% anatomical success rate for large or failed macular holes over a 6-month follow-up.
- Trial name
- MACROHOLE (NCT06433284)
- Testing
- 25-gauge pars plana vitrectomy with inverted flap technique and SF6 tamponade, 25-gauge pars plana vitrectomy with complete internal limiting membrane peeling with amniotic membrane hydrogel filling and SF6 tamponade
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- Walailak University
Extracorporeal Membrane Oxygenation Complication
Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Trial name
- ECMOX1 (NCT04282525)
- Testing
- ECMO for hemodynamic or respiratory indication
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Epiretinal Membrane, Macular Edema
A Pilot Study of the Effectiveness of Intra-operative Ozurdex® in Vitrectomy Surgery for Epiretinal Membranes
To determine if an intravitreal sustained release dexamethasone implant (Ozurdex®) injected at the conclusion of surgery in patients undergoing vitrectomy and membrane peeling for idiopathic epiretinal membranes is safe and…
- Trial name
- NCT01701518
- Testing
- Ozurdex
- Where
- 2 sites in Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Inferior Turbinate Hypertrophy, Nasal Obstruction
Efficacy And Safety of An IRE System For Treatment of Inferior Turbinate Hypertrophy
The purpose of the IRE System is to address the clinical need for reducing the volume of hypertrophic inferior turbinate(s) causing nasal obstruction while minimizing side effects and complications.
- Conditions
- Inferior Turbinate Hypertrophy, Nasal Obstruction, Turbinate; Hypertrophy Mucous Membrane
- Trial name
- NCT06438185
- Testing
- IRE System
- Where
- 4 sites in Israel, Lithuania and 2 more
- Volunteers
- 48 people
- Sponsor
- ENTire Medical Ltd.
Primary Membranous Nephropathy
Optimization of a Decision Formula for Optimal Timing of Immunosuppressive Therapy Initiation in Primary Membranous Nephropathy: A Multicenter Retrospective Cohort Study
The goal of this observational study is to optimize the evaluation formula for the timing of initiating immunosuppressive therapy in primary membranous nephropathy in patients with primary membranous nephropathy.
- Trial name
- NCT06924476
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Yipeng Liu
Rotator Cuff Tear
Rotator Cuff Repair Using Standard Double Row Technique With Platelet Rich Fibrin Membrane vs. Standard Double Row Technique
This study is a single-blind, randomized study evaluating the 6 month and 2 year outcomes of patients treated with arthroscopic rotator cuff repair using one of two techniques.
- Trial name
- RCRPRFM (NCT02256891)
- Testing
- PRFM, Double Row
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Badly Broken Maxillary Premolars Indicated for Extraction, Badly Broken Down Vital Teeth
Soft Tissue Healing After Tooth Extraction
Statement of the problem: Tooth extraction results in hard and soft tissue loss which complicates prosthodontic rehabilitation, So different techniques of alveolar ridge preservation should be done to maintain hard and soft…
- Trial name
- NCT06835543
- Testing
- Amnion membrane., Chorion membrane
- Where
- Egypt
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
End Stage Renal Disease, Haemodialysis
Comparison of Citrate and Heparin Anticoagulation During Hemodialysis With MCO PES-PVP (Theranova) Membrane
The purpose of the study is to compare the efficiency and biocompatibility of citrate and heparin anticoagulation during hemodialysis with medium cut-off polyarylethersulphone-polyvinylpirrolidone membrane (Theranova®).
- Conditions
- End Stage Renal Disease, Haemodialysis, Anticoagulation
- Trial name
- NCT04139525
- Testing
- unfractionated heparin, 8% trisodium citrate
- Where
- Slovenia
- Volunteers
- 32 people
- Sponsor
- Marija Malgaj Vrečko
Sepsis
Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane
Sepsis remains a global scourge. Before the SARS-CoV-2 pandemic, the World Health Organization estimated approximately 49 million cases annually, resulting in 11 million deaths.
- Trial name
- PLAQSIRIS (NCT06440317)
- Testing
- Hemofiltration membranes (the oXiris membrane® and the HF1400® membrane)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
AKI - Acute Kidney Injury
Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane
This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane.
- Trial name
- NCT06543940
- Testing
- Vancomycin
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Mahidol University
Peritoneal Membrane Failure
The Effect of Aliskiren and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients
This is a prospective, randomized, placebo controlled, multi-center clinical trial to determine whether aliskiren or aliskiren plus losartan or enalapril plus losartan effects on peritoneal membrane transportation.
- Trial name
- NCT01305850
- Testing
- Aliskiren, Aliskiren plus Losartan, Enalapril plus Losartan
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University
Preterm Premature Rupture of Membrane
Effect of Progesterone on Latent Phase Prolongation in Patients With Preterm Premature Rupture of Membranes
The aim of the study is to assess the efficacy of 17-hydroxyprogesterone caproate (17P) therapy on the latency period in pregnant women with Preterm premature rupture of membranes.
- Trial name
- NCT04807543
- Testing
- 17-hydroxyprogesterone caproate, Castor Oil
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
ARDS
IMV to Accelerate Recovery of Lung Function in Veno-venous Extracorporeal Membrane Oxygenation; Lung Rest Or Moderate Mechanical Ventilation in ECMO
Feasibility trial to inform a future multicentre randomized control trial. The investigators aim to evaluate the feasibility of a trial of near apnoeic ventilation (two breaths per minute) compared with standard ventilation…
- Trial name
- ROMEO (NCT06006676)
- Testing
- Near Apnoeic ventilation, Crossover standardised ECMO weaning trials
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Epiretinal Membrane
Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane
Fundus autofluorescence (FAF) at the macula originates from hyperfluorescence from retinal pigment epithelium (RPE) and blockage of hyperfluorescence by macular pigment.
- Trial name
- NCT02628158
- Testing
- Vitrectomy with internal limiting membrane removal
- Where
- Japan
- Volunteers
- 91 people
- Sponsor
- Kyorin University
Ridge Preservation Technique
The Effect of Tetracycline in Degradation and Permeability of Collagen Membrane
The main objective of this study was to evaluate the histological impact of treatment with tetracycline (TTC) solution of two layers collagen membranes (CMs) bio-degradation, in ridge preservation technique (RPT).
- Trial name
- NCT02057926
- Testing
- The effect of tetracycline in degradation and permeability of collagen membranes.
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Tooth Extraction
The Effect of Alveolar Ridge Preservation After Tooth Extraction in the Posterior Maxilla
This study is designed to assess the effects of Alveolar Ridge Preservation (ARP) after tooth extraction compared to extraction alone in the posterior maxilla.
- Trial name
- NCT02952209
- Testing
- Xenograft
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock.
- Trial name
- LEVOECMO (NCT04728932)
- Testing
- Levosimendan
- Where
- 3 sites in France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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